The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
ATP‐Responsive Aptamer‐Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs
Abstract
Nanoparticles consisting of metal–organic frameworks (NMOFs) modified with nucleic acid binding strands are synthesized. The NMOFs are loaded with a fluorescent agent or with the anticancer drug doxorubicin, and the loaded NMOFs are capped by hybridization with a complementary nucleic acid that includes the ATP‐aptamer or the ATP‐AS1411 hybrid aptamer in caged configurations. The NMOFs are unlocked in the presence of ATP via the formation of ATP‐aptamer complexes, resulting in the release of the loads. As ATP is overexpressed in cancer cells, and since the AS1411 aptamer recognizes the nucleolin receptor sites on the cancer cell membrane, the doxorubicin‐loaded NMOFs provide functional carriers for targeting and treatment of cancer cells. Preliminary cell experiments reveal impressive selective permeation of the NMOFs into MDA‐MB‐231 breast cancer cells as compared to MCF‐10A normal epithelial breast cells. High cytotoxic efficacy and targeted drug release are observed with the ATP‐AS1411‐functionalized doxorubicin‐loaded NMOFs.
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Cites
Metal–organic frameworks as platforms for clean energy
Li, S.-L., & Xu, Q. (2013) · Energy & Environmental Science · doi:10.1039/c3ee40507a · Cited by 970
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
pH‐Stimulated DNA Hydrogels Exhibiting Shape‐Memory Properties
Guo, W., Lu, C., Orbach, R., Wang, F., Qi, X., Cecconello, A., Seliktar, D., & Willner, I. (2015) · Advanced Materials · doi:10.1002/adma.201403702 · Cited by 388
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Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Chandrakala, V., Aruna, V., & Angajala, G. (2022) · Emergent Materials · doi:10.1007/s42247-021-00335-x · Cited by 768
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Self-citationZhang, L., Liu, Z., Deng, Q., Sang, Y., Dong, K., Ren, J., & Qu, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012487 · Cited by 357
Zhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
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Metadata
- Authors
- Chen, W., Yu, X., Liao, W., Sohn, Y. S., Cecconello, A., Kozell, A., Nechushtai, R., & Willner, I.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2017-07-20
- Volume
- 27
- Issue
- 37
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2738889610
- Cited by
- 211
- References
- 3
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, W., Yu, X., Liao, W., Sohn, Y. S., Cecconello, A., Kozell, A., Nechushtai, R., & Willner, I. (2017). ATP‐Responsive Aptamer‐Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs. Advanced Functional Materials. https://doi.org/10.1002/adfm.201702102
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