pH‐Stimulated DNA Hydrogels Exhibiting Shape‐Memory Properties
Abstract
Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.
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The above two features differ notably from common shape memory hydrogels for which shape changing kinetics is strongly affected by device dimension due to inside-and-out water diffusion.
“The above two features differ notably from common shape memory hydrogels 21-24 for which the shape changing kinetics is strongly affected by the device dimension due to the inside-and-out water diffusion 25 .”
From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [22]
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Self-citation
- Authors
- Guo, W., Lu, C., Orbach, R., Wang, F., Qi, X., Cecconello, A., Seliktar, D., & Willner, I.
- Affiliations
- Hebrew University of Jerusalem (IL)
- The Institute of Chemistry The Center for Nanoscience and Nanotechnology The Hebrew University of Jerusalem Jerusalem 91904 Israel
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Willner, Itamar
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2014-11-06
- Volume
- 27
- Issue
- 1
- Pages
- 73-78
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2170038819
- Cited by
- 388
- References
- 40
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 37 · 2023: 27 · 2022: 32 · 2021: 47 · 2020: 43 · 2019: 56 · 2018: 34 · 2017: 36 · 2016: 26 · 2015: 21
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Seventh Framework Programme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Keywords
- DNA hydrogels, shape memory materials, pH-responsive hydrogels, i-motif, nucleic acid duplexes, polyacrylamide, hydrogel regeneration
- MeSH terms
- Circular Dichroism, DNA, Hydrogen-Ion Concentration, Microscopy, Electron, Scanning, Polymers, Rheology, Spectrum Analysis, Hydrogels, Acrylamide
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