The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cancer Cell Membrane‐Biomimetic Oxygen Nanocarrier for Breaking Hypoxia‐Induced Chemoresistance
Abstract
The inadequate oxygen supply in solid tumor causes hypoxia, which leads to drug resistance and poor chemotherapy outcomes. To solve this problem, a cancer cell membrane camouflaged nanocarrier is developed with a polymeric core encapsulating hemoglobin (Hb) and doxorubicin (DOX) for efficient chemotherapy. The designed nanoparticles (DHCNPs) retain the cancer cell adhesion molecules on the surface of nanoparticles for homologous targeting and possess the oxygen‐carrying capacity of Hb for O 2‐interfered chemotherapy. The results show that DHCNPs not only achieve higher tumor specificity and lower toxicity by homologous targeting but also significantly reduce the exocytosis of DOX via suppressing the expressions of hypoxia‐inducible factor‐1α, multidrug resistance gene 1, and P‐glycoprotein, thus resulting in safe and high‐efficient chemotherapy. This work presents a new paradigm for targeted oxygen interference therapy by conquering hypoxia‐involved therapeutic resistance and achieves effective treatment of solid tumors.
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1 retracted
Samanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421438111 · Cited by 460
RetractedTargeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520
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Zhang, Y., Wang, F., Liu, C., Wang, Z., Kang, L., Huang, Y., Dong, K., Ren, J., & Qu, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b07746 · Cited by 854
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Jia, C., Guo, Y., & Wu, F. (2022) · Small · doi:10.1002/smll.202103868 · Cited by 685
Jiang, Q., Liu, Y., Guo, R., Yao, X., Sung, S., Pang, Z., & Yang, W. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.021 · Cited by 398
Chen, Z., Liu, L., Liang, R., Luo, Z., He, H., Wu, Z., Tian, H., Zheng, M., Ma, Y., & Cai, L. (2018) · ACS Nano · doi:10.1021/acsnano.8b04371 · Cited by 363
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Metadata
- Authors
- Tian, H., Luo, Z., Liu, L., Zheng, M., Chen, Z., Ma, A., Liang, R., Han, Z., Lu, C., & Cai, L.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2017-08-18
- Volume
- 27
- Issue
- 38
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2746410078
- Cited by
- 243
- References
- 4
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
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