Cell Membrane Coating Nanotechnology
Open accessAbstract
Nanoparticle‐based therapeutic, prevention, and detection modalities have the potential to greatly impact how diseases are diagnosed and managed in the clinic. With the wide range of nanomaterials available, the rational design of nanocarriers on an application‐specific basis has become increasingly commonplace. Here, a comprehensive overview is provided on an emerging platform: cell‐membrane‐coating nanotechnology. As a fundamental unit of biology, cells carry out a wide range of functions, including the remarkable ability to interface and interact with their surrounding environment. Instead of attempting to replicate such functions via synthetic techniques, researchers are now directly leveraging naturally derived cell membranes as a means of bestowing nanoparticles with enhanced biointerfacing capabilities. This top‐down technique is facile, highly generalizable, and has the potential to greatly augment existing nanocarriers. Further, the introduction of a natural membrane substrate onto nanoparticles surfaces has enabled additional applications beyond those traditionally associated with nanomedicine. Despite its relative youth, there exists an impressive body of literature on cell membrane coating, which is covered here in detail. Overall, there is still significant room for development, as researchers continue to refine existing workflows while finding new and exciting applications that can take advantage of this developing technology.
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Membranes of interest can serve as outer layer of delivery systems due to molecular interactions and specific receptor recognition.
“the membranes of interest could be serve as the outer layer of the delivery systems.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [190]
Cell membrane coating has become recognized as a viable means of overcoming the limitations of conventional nanoparticles.
“Due to the numerous proteins that are present on the surface of cell membranes, cell membrane coating has become recognized as a viable means of overcoming these limitations.64,65”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [65]
Naturally derived membrane lipids can also be applied for mRNA delivery.
“Naturally derived membrane lipids (for example, exosomes and cell membranes) can also be applied for mRNA delivery116,249,250.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [250]
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- Authors
- Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Zhang, Liangfang
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-03-27
- Volume
- 30
- Issue
- 23
- Pages
- e1706759-e1706759
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- PMC
- PMC5984176
- OpenAlex
- W2794683780
- Cited by
- 1,885
- References
- 132
- Citations by year
- 2026: 244 · 2025: 255 · 2024: 311 · 2023: 311 · 2022: 251 · 2021: 239 · 2020: 163 · 2019: 88 · 2018: 22 · 2013: 1
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Defense Threat Reduction Agency (HDTRA1‐14‐1‐0064)
- National Science Foundation (DMR‐1505699)
- National Institutes of Health (R01CA200574)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- cell membrane coating, nanoparticle functionalization, nanocarriers, biointerfacing, nanomedicine, drug delivery, disease detection
- MeSH terms
- Cell Membrane, Drug Delivery Systems, Nanotechnology, Nanomedicine, Nanoparticles
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