The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Enzyme‐Powered Nanobots Enhance Anticancer Drug Delivery
Abstract
The use of enzyme catalysis to power micro‐ and nanomotors exploiting biocompatible fuels has opened new ventures for biomedical applications such as the active transport and delivery of specific drugs to the site of interest. Here, urease‐powered nanomotors (nanobots) for doxorubicin (Dox) anticancer drug loading, release, and efficient delivery to cells are presented. These mesoporous silica‐based core–shell nanobots are able to self‐propel in ionic media, as confirmed by optical tracking and dynamic light scattering analysis. A four‐fold increase in drug release is achieved by nanobots after 6 h compared to their passive counterparts. Furthermore, the use of Dox‐loaded nanobots presents an enhanced anticancer efficiency toward HeLa cells, which arises from a synergistic effect of the enhanced drug release and the ammonia produced at high concentrations of urea substrate. A higher content of Dox inside HeLa cells is detected after 1, 4, 6, and 24 h incubation with active nanobots compared to passive Dox‐loaded nanoparticles. The improvement in drug delivery efficiency achieved by enzyme‐powered nanobots may hold potential toward their use in future biomedical applications such as the substrate‐triggered release of drugs in target locations.
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Cited by
Engineering microrobots for targeted cancer therapies from a medical perspective
Schmidt, C. K., Medina-Sánchez, M., Edmondson, R. J., & Schmidt, O. G. (2020) · Nature Communications · doi:10.1038/s41467-020-19322-7 · Cited by 441
Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors
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Metadata
- Authors
- Hortelão, A. C., Patiño, T., Perez‐Jiménez, A., Blanco, À., & Sánchez, S.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2017-11-27
- Volume
- 28
- Issue
- 25
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2770579810
- Cited by
- 316
- References
- 51
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- closed
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