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Cited by 150Micro and Nano RoboticsNeuroscience and Neural EngineeringAdvanced MEMS and NEMS Technologies

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem-Like Cell Stimulation

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Liu, Lu, Chen, Bin, Liu, Kun, Gao, Junbin, Ye, Yicheng, Wang, Zhen, Qin, Ni, Wilson, Daniela A. +2 more·2020·Advanced Functional Materials
DOI 10.1002/adfm.201910108
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Abstract

Abstract Precise neural electrical stimulation, which is a means of promoting neuronal regeneration, is a promising solution for patients with neurotrauma and neurodegenerative diseases. In this study, wirelessly controllable targeted motion and precise stimulation at the single‐cell level using S.platensis @Fe 3 O 4 @tBaTiO 3 micromotors are successfully demonstrated for the first time. A highly versatile and multifunctional biohybrid soft micromotor is fabricated via the integration of S.platensis with magnetic Fe 3 O 4 nanoparticles and piezoelectric BaTiO 3 nanoparticles. The results show that this micromotor system can achieve navigation in a highly controllable manner under a low‐strength rotating magnetic field. The as‐developed system can achieve single‐cell targeted motion and then precisely induce the differentiation of the targeted neural stem‐like cell by converting ultrasonic energy to an electrical signal in situ owing to the piezoelectric effect. This new approach toward the high‐precision stimulation of neural stem‐like cells opens up new applications for micromotors and has excellent potential for precise neuronal regenerative therapies.

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  • A wirelessly controllable S. platensis-Fe3O4-tBaTiO3 micromotor precisely induced differentiation of targeted neural stem-like cells by converting ultrasonic energy to an electrical signal in situ.

    “The microalga was coated with magnetic Fe3O4 and piezoelectric BaTiO3 nanoparticles, and the biohybrid micromotors could precisely induce the differentiation of the targeted neural stem-like cell by converting ultrasonic energy to an electrical signal in situ.”

    From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [161]

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Authors
Liu, L., Chen, B., Liu, K., Gao, J., Ye, Y., Wang, Z., Qin, N., Wilson, D. A., Tu, Y., & Peng, F.
Affiliations
  • Sun Yat-sen University (CN)
  • Southern Medical University (CN)
  • Radboud University Nijmegen (NL)
Corresponding author
  • Tu, Yingfeng
  • Peng, Fei
ORCID
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2020-01-22
Volume
30
Issue
11
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
DOI
10.1002/adfm.201910108
OpenAlex
W3001234734
Cited by
150
References
76
Citations by year
2026: 10 · 2025: 19 · 2024: 35 · 2023: 27 · 2022: 26 · 2021: 19 · 2020: 14
FWCI
21.09
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Functional Materials (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
National Natural Science Foundation of China (21805318, 51973241, 31800835)
Topics
  • Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced MEMS and NEMS Technologies
Keywords
micromotors, piezoelectric properties, Fe3O4 nanoparticles, BaTiO3 nanoparticles, cell differentiation, neuronal regeneration, neurodegenerative diseases

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