Photothermal Modulation of Depression‐Related Ion Channel Function through Conjugated Polymer Nanoparticles
Abstract
Considering recent breakthroughs in the field of optogenetics, a powerful tool is established in the present study to modulate the activities of target neurons through the application of light‐based methods. Near‐infrared (NIR) light enables the penetration of deep‐tissue. As a result, it can be used to modulate the functions of proteins/cells. Herein, it is aimed to develop a NIR light‐sensitive drug delivery system to spatially and temporally control the activation of the loaded drug at the stimulation sites through its release from a nanoparticle sensitive to NIR. Owing to their excellent photothermal effect under NIR irradiation, the nanoparticles are found to penetrate the blood‐brain barrier effectively, ultimately reaching neurons. Furthermore, by loading fasudil, a selective activator of the Kv7.4 potassium channel, into the precisely designed and synthesized NIR light‐sensitive nanoparticles, the firing frequency of dopaminergic neurons in the ventral tegmental area is found to be remarkably reduced upon NIR light irradiation. Such findings shed light on a new concept that can be used for developing more selective drug therapies for the treatment of diseases, such as major depression.
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NIR irradiation for BBB permeability regulation under infrared thermal monitoring with head temperature <43°C causes negligible brain damage confirmed by histological staining.
“NIR irradiation for BBB permeability regulation was applied under infrared thermal monitoring and the head temperature was kept lower than 43 °C. At this power intensity, the irradiation caused negligible brain damage confirmed by histological staining.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [213]
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The role of dopamine in the pathophysiology of depression
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
“213,214 The reduced transendothelial electrical resistance of cellular monolayer induced by irradiation could recover within 10 min.”
BackgroundSelf-citation
- Authors
- Li, B., Wang, Y., Gao, D., Ren, S., Li, L., Li, N., An, H., Zhu, T., Yang, Y., Zhang, H., & Xing, C.
- Affiliations
- Hebei University of Technology (CN)
- Hebei Medical University (CN)
- Corresponding author
- Zhang, Hailin
- Xing, Chengfen
- ORCID
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2021-03-03
- Volume
- 31
- Issue
- 19
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3135085258
- Cited by
- 41
- References
- 4
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 5
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- National Natural Science Foundation of China (21773054, 21905072, 22077025, 91732108, 81500057)
- Natural Science Foundation of Hebei Province (B2020202062, B2020202086)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- photothermal effect, near-infrared light, conjugated polymer nanoparticles, depression, fasudil, dopaminergic neurons, ventral tegmental area, blood-brain barrier penetration, optogenetics, neuronal firing rate
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