The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Towards an Improved anti‐HIV Activity of NRTI via Metal–Organic Frameworks Nanoparticles
Open accessAbstract
Nanoscale mesoporous iron carboxylates metal–organic frameworks (nanoMOFs) have recently emerged as promising platforms for drug delivery, showing biodegradability, biocompatibility and important loading capability of challenging highly water‐soluble drugs such as azidothymidine tryphosphate (AZT‐TP). In this study, nanoMOFs made of iron trimesate (MIL‐100) were able to act as efficient molecular sponges, quickly adsorbing up to 24 wt% AZT‐TP with entrapment efficiencies close to 100%, without perturbation of the supramolecular crystalline organization. These data are in agreement with molecular modelling predictions, indicating maximal loadings of 33 wt% and preferential location of the drug in the large cages. Spectrophotometry, isothermal titration calorimetry, and solid state NMR investigations enable to gain insight on the mechanism of interaction of AZT and AZT‐TP with the nanoMOFs, pointing out the crucial role of phosphates strongly coordinating with the unsaturated iron(III) sites. Finally, contrarily to the free AZT‐TP, the loaded nanoparticles efficiently penetrate and release their cargo of active triphosphorylated AZT inside major HIV target cells, efficiently protecting against HIV infection.
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Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Lehrman, S. N., Bolognesi, D. P., Broder, S., & Mitsuya, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8333 · Cited by 1,347
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Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Self-citationToxicity of metal–organic framework nanoparticles: from essential analyses to potential applications
Ettlinger, R., Lächelt, U., Gref, R., Horcajada, P., Lammers, T., Serre, C., Couvreur, P., Morris, R. E., & Wuttke, S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00918d · Cited by 423
Self-citationCai, W., Gao, H., Chu, C., Wang, X., Wang, J., Zhang, P., Lin, G., Li, W., Liu, G., & Chen, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11579 · Cited by 357
Beg, S., Rahman, M., Jain, A., Saini, S., Midoux, P., Pichon, C., Ahmad, F. J., & Akhter, S. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.10.001 · Cited by 284
Jain-Beuguel, C., LI, X., Houel-Renault, L., Modjinou, T., Simon-Colin, C., Gref, R., Renard, E., & Langlois, V. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00870 · Cited by 23
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Metadata
- Authors
- Agostoni, V., Chalati, T., Horcajada, P., Willaime, H., Anand, R., Semiramoth, N., Baati, T., Hall, S., Maurin, G., Chacun, H., Bouchemal, K., Martineau, C., Taulelle, F., Couvreur, P., Rogez‐Kreuz, C., Clayette, P., Monti, S., Serre, C., & Gref, R.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2013-06-17
- Volume
- 2
- Issue
- 12
- Pages
- 1630-1637
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2148702736
- Cited by
- 163
- References
- 1
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Agostoni, V., Chalati, T., Horcajada, P., Willaime, H., Anand, R., Semiramoth, N., Baati, T., Hall, S., Maurin, G., Chacun, H., Bouchemal, K., Martineau, C., Taulelle, F., Couvreur, P., Rogez‐Kreuz, C., Clayette, P., Monti, S., Serre, C., & Gref, R. (2013). Towards an Improved anti‐HIV Activity of NRTI via Metal–Organic Frameworks Nanoparticles. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201200454
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
