The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.
Metal-organic frameworks for advanced drug delivery
Open accessAbstract
coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.
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Self-citationEnhanced dissolution of anticancer drug letrozole from mesoporous zeolite clinoptilolite
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Metadata
- Authors
- He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., Gref, R., & Zhang, J.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 11
- Issue
- 8
- Pages
- 2362-2395
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W3137776543
- Cited by
- 528
- References
- 237
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., Gref, R., & Zhang, J. (2021). Metal-organic frameworks for advanced drug delivery. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2021.03.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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