The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Insight into the Cellular Internalization and Cytotoxicity of Graphene Quantum Dots
Abstract
Graphene quantum dots (GQDs), owing to their unique morphology, ultra‐small lateral sizes, and exceptional properties, hold great promise for many applications, especially in the biomedical field. In this work, the cellular internalization, distribution, and cytotoxicity of the GQDs are explored complementarily using transmission electron microscopy, confocal laser scanning microscopy, UV‐vis, and fluorescence spectroscopies, and flow cytometry with human gastric cancer MGC‐803 and breast cancer MCF‐7 cells. It is demonstrated that the GQDs are internalized primarily through caveolae‐mediated endocytosis. The effects of GQDs on the cell viability, internal cellular reactive oxygen species (ROS) level, mitochondrial membranes potential, and cell cycles show that the cytotoxicity of GQDs is lower than that of the micrometer‐sized graphene oxide (GO). The low cytotoxicity and size consistence render GQDs appropriate for biomedical application.
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Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Reduction of graphene oxide via l -ascorbic acid
Zhang, J., Yang, H., Shen, G., Cheng, P., Zhang, J., & Guo, S. (2010) · Chem. Commun. · doi:10.1039/b917705a · Cited by 2,344
Self-citation
Cited by
Zhao, S., Lan, M., Zhu, X., Xue, H., Ng, T.-W., Meng, X., Lee, C.-S., Wang, P., & Zhang, W. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b03228 · Cited by 649
Jian, H.-J., Wu, R.-S., Lin, T.-Y., Li, Y.-J., Lin, H.-J., Harroun, S. G., Lai, J.-Y., & Huang, C.-C. (2017) · ACS Nano · doi:10.1021/acsnano.7b01023 · Cited by 507
Bioimaging based on fluorescent carbon dots
Song, Y., Zhu, S., & Yang, B. (2014) · RSC Advances · doi:10.1039/c3ra47994c · Cited by 414
Ge, J., Jia, Q., Liu, W., Lan, M., Zhou, B., Guo, L., Zhou, H., Zhang, H., Wang, Y., Gu, Y., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500720 · Cited by 309
Quantum Dots as A Theranostic Approach in Alzheimer’s Disease: A Systematic Review
Villalva, M. D., Agarwal, V., Ulanova, M., Sachdev, P. S., & Braidy, N. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0104 · Cited by 53
Metadata
- Authors
- Wu, C., Wang, C., Han, T., Zhou, X., Guo, S., & Zhang, J.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2013-05-24
- Volume
- 2
- Issue
- 12
- Pages
- 1613-1619
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2064654473
- Cited by
- 216
- References
- 2
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- closed
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