Cited by 54Quantum Dots Synthesis And PropertiesAlzheimer's disease research and treatmentsNanoplatforms for cancer theranostics

Quantum Dots as A Theranostic Approach in Alzheimer’s Disease: A Systematic Review

Villalva, Maria D, Agarwal, Vipul, Ulanova, Marina, Sachdev, Perminder S, Braidy, Nady·2021·Nanomedicine

Abstract

Aim: Quantum dots (QDs) are nanoparticles that have an emerging application as theranostic agents in several neurodegenerative diseases. The advantage of QDs as nanomedicine is due to their unique optical properties that provide high sensitivity, stability and selectivity at a nanoscale range. Objective: To offer renewed insight into current QD research and elucidate its promising application in Alzheimer's disease (AD) diagnosis and therapy. Methods: A comprehensive literature search was conducted in PubMed and Google Scholar databases that included the following search terms: ‘quantum dots’, ‘blood–brain barrier’, ‘cytotoxicity’, ‘toxicity’ and ‘Alzheimer's disease’; PRISMA guidelines were adhered to. Results: Thirty-four publications were selected to evaluate the ability of QDs to cross the blood–brain barrier, potential toxicity and current AD diagnostic and therapeutic applications. Conclusion: QD's unique optical properties and versatility to conjugate to various biomolecules, while maintaining a nanoscale size, render them a promising theranostic tool in AD.

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Registry

Crossref · 10.2217/nnm-2021-0104

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125 of 125 references verified0 citation errors · 0 not checkable

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  • For QD, diagnostic concentrations range from 50 nM to 15 mg/kg, while therapeutic ones vary from 5 μM to 200 μg/kg.

    “For QD, diagnostic concentrations range from 50 nM to 15 mg/kg, while therapeutic ones vary from 5 μM to 200 μg/kg [91].”
  • An analysis of the systematic reviews by Villalva and co-authors on QD and Aminyavari and co-authors on SPIONs showed that neither provides an example of a nanoparticle for which both diagnostic and therapeutic doses were quantitatively determined within a single study.

    “An analysis of the systematic reviews by Villalva and co-authors [91] on QD and Aminyavari and co-authors [92] on SPIONs showed that neither provides an example of a nanoparticle for which both diagnostic and therapeutic doses were quantitatively determined within a single study.”
  • In the tables summarizing diagnostic and therapeutic approaches, different sets of particles appear.

    “In the tables summarizing diagnostic and therapeutic approaches, different sets of particles appear [91,92].”

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Authors
Villalva, M. D., Agarwal, V., Ulanova, M., Sachdev, P. S., & Braidy, N.
Affiliations
UNSW Sydney (AU)
Venue
Nanomedicine
Published
2021-06-28
Volume
16
Issue
18
Pages
1595-1611
ISSN
  • 1743-5889 (ISSN-L)
  • 1748-6963
OpenAlex
W3173763732
Cited by
53
References
125
Citations by year
2026: 8 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 6 · 2021: 4
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Locations
  • Nanomedicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Health and Medical Research Council (GNT1139060)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
quantum dots, Alzheimer's disease, theranostics, blood-brain barrier, nanoparticle toxicity, cytotoxicity, optical properties, biomolecule conjugation, neurodegenerative disease diagnosis, Alzheimer's disease treatment
MeSH terms
Theranostic Nanomedicine, Alzheimer Disease, Humans, Quantum Dots, Nanomedicine, Nanoparticles, Precision Medicine

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