The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization
Open accessAbstract
Microneedle vaccines mimic several aspects of cutaneous pathogen invasion by targeting antigen to skin‐resident dendritic cells and triggering local inflammatory responses in the skin, which are correlated with enhanced immune responses. Here, we tested whether control over vaccine delivery kinetics can enhance immunity through further mimicry of kinetic profiles present during natural acute infections. An approach for the fabrication of silk/poly(acrylic acid) (PAA) composite microneedles composed of a silk tip supported on a PAA base is reported. On brief application of microneedle patches to skin, the PAA bases rapidly dissolved to deliver a protein subunit vaccine bolus, while also implanting persistent silk hydrogel depots into the skin for a low‐level sustained cutaneous vaccine release over 1–2 weeks. Use of this platform to deliver a model whole‐protein vaccine with optimized release kinetics resulted in >10‐fold increases in antigen‐specific T‐cell and humoral immune responses relative to traditional parenteral needle‐based immunization.
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Cites
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Cited by
Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.012 · Cited by 433
Self-citationRecent advances of controlled drug delivery using microfluidic platforms
Sanjay, S. T., Zhou, W., Dou, M., Tavakoli, H., Ma, L., Xu, F., & Li, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.013 · Cited by 365
Ye, Y., Wang, J., Hu, Q., Hochu, G. M., Xin, H., Wang, C., & Gu, Z. (2016) · ACS Nano · doi:10.1021/acsnano.6b04989 · Cited by 339
Designing spatial and temporal control of vaccine responses
Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00372-2 · Cited by 316
Metadata
- Authors
- DeMuth, P. C., Min, Y., Irvine, D. J., & Hammond, P. T.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2013-07-12
- Volume
- 3
- Issue
- 1
- Pages
- 47-58
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W1973347307
- Cited by
- 171
- References
- 1
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- green
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- DeMuth, P. C., Min, Y., Irvine, D. J., & Hammond, P. T. (2014). Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201300139
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
