The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Designing spatial and temporal control of vaccine responses
Open accessAbstract
Vaccines are the key technology to combat existing and emerging infectious diseases. However, increasing the potency, quality and durability of the vaccine response remains a challenge. As our knowledge of the immune system deepens, it becomes clear that vaccine components must be in the right place at the right time to orchestrate a potent and durable response. Material platforms, such as nanoparticles, hydrogels and microneedles, can be engineered to spatially and temporally control the interactions of vaccine components with immune cells. Materials-based vaccination strategies can augment the immune response by improving innate immune cell activation, creating local inflammatory niches, targeting lymph node delivery and controlling the time frame of vaccine delivery, with the goal of inducing enhanced memory immunity to protect against future infections. In this Review, we highlight the biological mechanisms underlying strong humoral and cell-mediated immune responses and explore materials design strategies to manipulate and control these mechanisms. The immune response to a vaccine is characterized by a complex time-dependent interplay between various cell types and molecules in different tissues in our body. This Review explores materials-based strategies for the spatial and temporal control of the mechanisms that underlie vaccine immune responses.
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Cites
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Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
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Machine Learning Methods for Small Data Challenges in Molecular Science
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Metadata
- Authors
- Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A.
- Venue
- Nature Reviews Materials
- Published
- 2021-09-28
- Volume
- 7
- Issue
- 3
- Pages
- 174-195
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W3203037161
- Cited by
- 316
- References
- 251
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021). Designing spatial and temporal control of vaccine responses. Nature Reviews Materials. https://doi.org/10.1038/s41578-021-00372-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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