The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enhanced Tumor Accumulation of Sub‐2 nm Gold Nanoclusters for Cancer Radiation Therapy
Open accessAbstract
A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nanoconstruct (GSH‐coated Au 25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small‐sized GSH‐Au 25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au 25 NCs in the body.
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Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Cited by
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Wang, H., Mu, X., He, H., & Zhang, X.-D. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.003 · Cited by 572
Self-citationInorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Engineering ultrasmall water-soluble gold and silver nanoclusters for biomedical applications
Luo, Z., Zheng, K., & Xie, J. (2014) · Chem. Commun. · doi:10.1039/c3cc47512c · Cited by 441
Self-citationUltrasmall Au10−12(SG)10−12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy
Zhang, X., Luo, Z., Chen, J., Shen, X., Song, S., Sun, Y., Fan, S., Fan, F., Leong, D. T., & Xie, J. (2014) · Advanced Materials · doi:10.1002/adma.201400866 · Cited by 440
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Metadata
- Authors
- Zhang, X., Chen, J., Luo, Z., Wu, D., Shen, X., Song, S., Sun, Y., Liu, P., Zhao, J., Huo, S., Fan, S., Fan, F., Liang, X., & Xie, J.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2013-07-22
- Volume
- 3
- Issue
- 1
- Pages
- 133-141
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W1973533775
- Cited by
- 373
- References
- 1
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, X., Chen, J., Luo, Z., Wu, D., Shen, X., Song, S., Sun, Y., Liu, P., Zhao, J., Huo, S., Fan, S., Fan, F., Liang, X., & Xie, J. (2014). Enhanced Tumor Accumulation of Sub‐2 nm Gold Nanoclusters for Cancer Radiation Therapy. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201300189
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