Renal clearance of quantum dots
Open accessAbstract
The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles. Zwitterionic or neutral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic diameter by >15 nm and prevented renal excretion. A final hydrodynamic diameter <5.5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
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The size of a nanoparticle influences its biodistribution and clearance.
“This is an excellent example of the influence of the size of a nanoparticle on its biodistribution and clearance.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [172]
Threshold for rapid renal excretion is about 5.5 nm; hydrodynamic diameters of prepared nanoparticles need to be larger than this size.
“Due to the threshold for rapid renal excretion being about 5.5 nm, the hydrodynamic diameters of the prepared nanoparticles need to be larger than this size [168–170].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [168]
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- Authors
- Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Bawendi, Moungi G
- Frangioni, John V
- Venue
- Nature Biotechnology
- Published
- 2007-09-23
- Volume
- 25
- Issue
- 10
- Pages
- 1165-1170
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- PMC
- PMC2702539
- OpenAlex
- W1965097716
- Cited by
- 4,476
- References
- 26
- Citations by year
- 2026: 207 · 2025: 179 · 2024: 229 · 2023: 216 · 2022: 254 · 2021: 251 · 2020: 314 · 2019: 308 · 2018: 303 · 2017: 299 · 2016: 287 · 2015: 286 · 2014: 289 · 2013: 271 · 2012: 235
- FWCI
- 64.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50gm068762-10, 5u54ca119349-05)
- National Cancer Institute (1U54 CA119349, U54 CA-119349)
- National Institute of General Medical Sciences (GM 68762, P50-GM068762)
- National Institute of Biomedical Imaging and Bioengineering (R21EB000673, R33EB000673)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Keywords
- quantum dots, renal clearance, urinary excretion, nanoparticle biodegradation, renal filtration, hydrodynamic diameter, protein adsorption, zwitterionic coatings, nanoparticle toxicity, nanoparticle design, nanomedicine
- MeSH terms
- Animals, Contrast Media, Diagnostic Imaging, Drug Stability, Kidney, Male, Particle Size, Rats, Sprague-Dawley, Nanotechnology, Quantum Dots, Rats
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