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Gel Scaffolds of BMP‐2‐Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis
Open accessAbstract
Peptide amphiphile (PA) nanofibers formed by self‐assembly can be customized for specific applications in regenerative medicine through the use of molecules that display bioactive signals on their surfaces. Here, the use of PA nanofibers with binding affinity for the bone promoting growth factor BMP‐2 to create a gel scaffold for osteogenesis is reported. With the objective of reducing the amount of BMP‐2 used clinically for successful arthrodesis in the spine, amounts of growth factor incorporated in the scaffolds that are 10 to 100 times lower than that those used clinically in collagen scaffolds are used. The efficacy of the bioactive PA system to promote BMP‐2‐induced osteogenesis in vivo is investigated in a rat posterolateral lumbar intertransverse spinal fusion model. PA nanofiber gels displaying BMP‐2‐binding segments exhibit superior spinal fusion rates relative to controls, effectively decreasing the required therapeutic dose of BMP‐2 by 10‐fold. Interestingly, a 42% fusion rate is observed for gels containing the bioactive nanofibers without the use of exogenous BMP‐2, suggesting the ability of the nanofiber to recruit endogenous growth factor. Results obtained here demonstrate that bioactive biomaterials with capacity to bind specific growth factors by design are great targets for regenerative medicine.
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“Similar work has shown promise in stem cell differentiation and neural regeneration following spinal injury in vivo200–202, further demonstrating the utility of peptide-based materials in cell culture.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [201]
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“To reduce the side effects associated with high rhBMP-2 doses, we developed a PA with a BMP-2-binding epitope (BMP-2-binding PA) to promote the localization of both endogenous and recombinant BMP-2, potentially reducing the therapeutic dose needed for fusion [17].”
Self-citationHydrogel Implementing Drug Delivery in Cranial Bone Tissue Engineering
Salvati, M., Vita, A., Arcovito, A., Parolini, O., Tiberio, F., & Lattanzi, W. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17080401
“In subsequent work, Lee et al. [163] achieved a 100% spinal fusion rate with lower BMP-2 doses and observed a 42% fusion rate even without exogenous BMP-2, suggesting recruitment of endogenous growth factors.”
Supramolecular engineering of fibrinogen into a fibrin matrix with enhanced bioactive properties
Laurenza, D., Macrae, F. L., Sapjanskaite, I., Hartley, A., Pramanik, B., Padilla‐Lopategui, S., Rose, F. R. A. J., Ariëns, R. A. S., & Mata, Á. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.08.013
“…epitopes such as RGDS [38] to promote cell adhesion, IKVAV [39] to foster cell growth or YRSRKYSSWYVALKR [40] to replicate the biological activity of FGF-2, as well as sites to modulate structural properties [41,42], or peptides to selectively bind molecules such as TGF-β 1 [43] and BMP-2 [44].”
Theoretical Quantification of Cargo Effective Diffusivity in Affinity-Based Hydrogels
Suthan, R., Koo, I. K., Wang, X., & Goh, K. B. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6c00188
Metadata
- Authors
- Lee, S. S., Hsu, E. L., Mendoza, M., Ghodasra, J., Nickoli, M. S., Ashtekar, A., Polavarapu, M., Babu, J., Riaz, R. M., Nicolas, J. D., Nelson, D., Hashmi, S. Z., Kaltz, S. R., Earhart, J. S., Merk, B. R., McKee, J. S., Bairstow, S. F., Shah, R. N., Hsu, W. K., & Stupp, S. I.
- Affiliations
- Northwestern University (US)
- Baxter (United States) (US)
- Corresponding author
- Stupp, Samuel I.
- ORCID
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-04-22
- Volume
- 4
- Issue
- 1
- Pages
- 131-141
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC4206675
- OpenAlex
- W2041261315
- Cited by
- 183
- References
- 48
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 15 · 2021: 22 · 2020: 19 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 12 · 2014: 2
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE015920)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- peptide amphiphile nanofibers, spinal fusion, bone formation, growth factor delivery, self-assembly, posterolateral lumbar fusion, regenerative medicine
- MeSH terms
- Animals, Cell Line, Disease Models, Animal, Female, Osteogenesis, Peptides, Spinal Diseases, Spinal Fusion, Rats, Sprague-Dawley, Implants, Experimental, Mice, Rats, Tissue Scaffolds, Bone Morphogenetic Protein 2, Nanofibers
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