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Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy
Abstract
The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology is developed to construct a multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T 1‐weighted magnetic resonance imaging (MRI), X‐ray computed tomography (CT) imaging, photothermal therapy (PTT), and chemotherapy, into one single nanoprobe (named as UCNP@PDA 5‐PEG‐DOX). For generating the UCNP@PDA 5‐PEG‐DOX, a near‐infrared light (NIR)‐absorbing polydopamine (PDA) shell is directly coated on oleic‐acid‐capped β‐NaGdF 4:Yb 3+,Er 3+@β‐NaGdF 4 upconverting nanoparticle (UCNP) core for the first time to form monodisperse, ultrastable, and noncytotoxic core–shell‐structured nanosphere via water‐in‐oil microemulsion approach. When combined with 808 nm NIR laser irradiation, the UCNP@PDA 5‐PEG‐DOX shows great synergistic interaction between PTT and the enhanced chemotherapy, resulting in completely eradicated mouse‐bearing SW620 tumor without regrowth. In addition, leakage study, hemolysis assay, histology analysis, and blood biochemistry assay unambiguously reveal that the UCNP@PDA 5‐PEG has inappreciable cytotoxicity and negligible organ toxicity. The results provide explicit strategy for fabricating multifunctional nanoplatforms from the integration of UCNP with NIR‐absorbing polymers, important for developing multi‐mode nanoprobes for biomedical applications.
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Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Attenuation of The In Vivo Toxicity of Biomaterials by Polydopamine Surface Modification
Hong, S., Kim, K. Y., Wook, H. J., Park, S. Y., Lee, K. D., Lee, D. Y., & Lee, H. (2011) · Nanomedicine · doi:10.2217/nnm.11.76 · Cited by 309
Cited by
Zeng, X., Luo, M., Liu, G., Wang, X., Tao, W., Lin, Y., Ji, X., Nie, L., & Mei, L. (2018) · Advanced Science · doi:10.1002/advs.201800510 · Cited by 598
Gao, G., Jiang, Y.-W., Jia, H.-R., & Wu, F.-G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.045 · Cited by 485
Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics
Wang, Z., Zou, Y., Li, Y., & Cheng, Y. (2020) · Small · doi:10.1002/smll.201907042 · Cited by 459
Self-citationWang, X., Zhang, J., Wang, Y., Wang, C., Xiao, J., Zhang, Q., & Cheng, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.037 · Cited by 411
Self-citationHuang, Y., Zhao, X., Zhang, Z., Liang, Y., Yin, Z., Chen, B., Bai, L., Han, Y., & Guo, B. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c02030 · Cited by 377
Metadata
- Authors
- Liu, F., He, X., Lei, Z., Liu, L., Zhang, J., You, H., Zhang, H., & Wang, Z.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-12-03
- Volume
- 4
- Issue
- 4
- Pages
- 559-568
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2133438169
- Cited by
- 185
- References
- 2
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Liu, F., He, X., Lei, Z., Liu, L., Zhang, J., You, H., Zhang, H., & Wang, Z. (2015). Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201400676
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