Attenuation of The In Vivo Toxicity of Biomaterials by Polydopamine Surface Modification
Abstract
Aims Polydopamine coating is emerging as a useful method of surface functionalization due to the ability of this compound to form a nanometer-scale organic thin film on virtually any material surface to which proteins, peptides, oligonucleotides, metal ions or synthetic polymers are able to be attached. The unique properties of polydopamine make this technique suitable for nanomedicine. To facilitate the use of polydopamine, evaluation of toxicity is of great importance. In this article, we investigated the in vivo toxicity of polydopamine. Results We found that the polydopamine functions as a biocompatible layer, attenuating adverse biological responses caused by intrinsic properties of the coated material. One-step polydopamine coating greatly reduced the inflammatory response to poly-L-lactic acid surfaces and the immunological responses of blood on quantum dots were also reduced. Conclusion Our results indicate that polydopamine provides a versatile platform that can reduce the in vivo toxicity of biomaterials that contact tissue or blood.
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A polydopamine-coated substrate of nylon/cellulose/polyethersulfone composite grafted with bovine serum albumin (BSA) can reduce attachment of blood platelets and selectively enable BSA to anchor on the surface, leading to a decrease in unwanted blood clotting.
“PDA-coated substrate of biosubstitute made of nylon/cellulose/polyethersulfone composite, grafted with bovine serum albumin (BSA), can reduce the attachment of blood platelets and selectively enable BSA to anchor on the surface, which leads to the decrease of unwanted blood clotting [81].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [81]
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- Authors
- Hong, S., Kim, K. Y., Wook, H. J., Park, S. Y., Lee, K. D., Lee, D. Y., & Lee, H.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Department of Bioengineering, Hanyang University, 17 Haengdang-dong, Seongdong-du, Seoul133-791, Republic of Korea
- Department of Chemical & Biological Engineering, Chungju National University, 50 Daehak Rd. Chung-Ju City 380-702, Republic of Korea
- Kosin University (KR)
- Hanyang University (KR)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 6
- Issue
- 5
- Pages
- 793-801
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2161170293
- Cited by
- 309
- References
- 41
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 21 · 2023: 16 · 2022: 21 · 2021: 21 · 2020: 26 · 2019: 23 · 2018: 36 · 2017: 21 · 2016: 23 · 2015: 18 · 2014: 15 · 2013: 23 · 2012: 17
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- polydopamine coating, surface functionalization, biocompatibility, poly(L-lactic acid), quantum dots, inflammation, hemocompatibility, immune response
- MeSH terms
- Animals, Indoles, Leukocytes, Macrophages, Mice, Inbred BALB C, Polyesters, Polymers, Surface Properties, Rats, Sprague-Dawley, Lactic Acid, Coated Materials, Biocompatible, Quantum Dots, Mice, Rats, Chromatography, Reverse-Phase
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