Transcatheter Heart Valves: A Biomaterials Perspective
Abstract
Heart valve disease is prevalent throughout the world, and the number of heart valve replacements is expected to increase rapidly in the coming years. Transcatheter heart valve replacement (THVR) provides a safe and minimally invasive means for heart valve replacement in high‐risk patients. The latest clinical data demonstrates that THVR is a practical solution for low‐risk patients. Despite these promising results, there is no long‐term (>20 years) durability data on transcatheter heart valves (THVs), raising concerns about material degeneration and long‐term performance. This review presents a detailed account of the materials development for THVRs. It provides a brief overview of THVR, the native valve properties, the criteria for an ideal THV, and how these devices are tested. A comprehensive review of materials and their applications in THVR, including how these materials are fabricated, prepared, and assembled into THVs is presented, followed by a discussion of current and future THVR biomaterial trends. The field of THVR is proliferating, and this review serves as a guide for understanding the development of THVs from a materials science and engineering perspective.
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Incorporating different proportions of other materials into PLCL matrix improves mechanical strength to meet heart valve needs.
“the researchers formed the new composite material by incorporating different proportions of other materials into the PLCL matrix to improve the mechanical strength of the material so that it can meet the needs of the heart valve [149, 171].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [171]
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References 258 · Cited by 36
- Authors
- Bui, H. T., Khair, N., Yeats, B., Gooden, S., James, S. P., & Dasi, L. P.
- Affiliations
- Georgia Institute of Technology (US)
- Colorado State University (US)
- Corresponding author
- Dasi, Lakshmi Prasad
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2021-05-26
- Volume
- 10
- Issue
- 15
- Pages
- e2100115-e2100115
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W3165393507
- Cited by
- 36
- References
- 258
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 7 · 2023: 5 · 2022: 5
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health Research (1R01HL119824‐01)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- transcatheter heart valve, biomaterials, valvular heart disease, valve durability, material degradation, device fabrication, device testing, high-risk patients
- MeSH terms
- Aortic Valve, Biocompatible Materials, Heart Valve Prosthesis, Heart Valves, Humans, Prosthesis Design, Treatment Outcome, Transcatheter Aortic Valve Replacement
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