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Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme
Abstract
In the presence of Pb2+, a cleaved enzyme–substrate complex releases ssDNA that adsorbs onto and stabilizes gold nanoparticles (AuNPs) against salt-induced aggregation. In the absence of Pb2+, the uncleaved complex can not stabilize the AuNPs, resulting in purple–blue AuNP aggregates (see figure). The sensor has a low detection limit of 3 nM, a high selectivity, and a tunable dynamic range.
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Citations
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Colorimetric Detection of Pb2+ Using Glutathione Functionalized Gold Nanoparticles
Chai, F., Wang, C., Wang, T., Li, L., & Su, Z. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am100107k · Cited by 375
Lake, R. J., Yang, Z., Zhang, J., & Lu, Y. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00419 · Cited by 281
Self-citationTemplated Spherical High Density Lipoprotein Nanoparticles
Thaxton, C. S., Daniel, W. L., Giljohann, D. A., Thomas, A. D., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808856z · Cited by 122
Metadata
- Authors
- Wang, Z., Lee, J. H., & Lu, Y.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2008-09
- Volume
- 20
- Issue
- 17
- Pages
- 3263-3267
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2051443885
- Cited by
- 446
- References
- 0
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Z., Lee, J. H., & Lu, Y. (2008). Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme. Advanced Materials. https://doi.org/10.1002/adma.200703181
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