Templated Spherical High Density Lipoprotein Nanoparticles
Open accessAbstract
We report the synthesis of high density lipoprotein (HDL) biomimetic nanoparticles capable of binding cholesterol. These structures use a gold nanoparticle core to template the assembly of a mixed phospholipid layer and the adsorption of apolipoprotein A-I. These synthesized structures have the general size and surface composition of natural HDL and, importantly, bind free cholesterol (K(d) = 4 nM). The determination of the K(d) for these particles, with respect to cholesterol complexation, provides a key starting and comparison point for measuring and evaluating the properties of subsequently developed synthetic versions of HDL.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biomimetic HDL nanoparticles incorporating gold nanocrystals or iron oxide have biophysical features closely resembling native HDL and similar cholesterol binding and efflux capabilities.
“Biomimetic HDL nanoparticles incorporating gold nanocrystals (Au–HDL) and iron oxide (FeO–HDL) have biophysical features that closely resemble those of native HDL, and have similar cholesterol binding and cholesterol efflux capabilities71,72.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [71]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ajees, A. A., Anantharamaiah, G. M., Mishra, V., Hussain, M. M., & Murthy, H. M. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506877103 · Cited by 204 · see citing works
RetractedDaniel, M., & Astruc, D. (2003) · Chemical Reviews · doi:10.1021/cr030698+ · Cited by 12,486 · see citing works
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,693 · see citing works
Self-citationElghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L., & Mirkin, C. A. (1997) · Science · doi:10.1126/science.277.5329.1078 · Cited by 4,399 · see citing works
Self-citationBraunwald's Heart Disease: A Textbook of Cardiovascular Medicine
Mann, D. L., Zipes, D. P., Libby, P., Bonow, R. O., & D, E. B. M. (2011) · Medical Entomology and Zoology · Cited by 3,745 · see citing works
Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection
Cao, Y. C., Jin, R. M., & Mirkin, C. A. (2002) · Science · doi:10.1126/science.297.5586.1536 · Cited by 2,977 · see citing works
Self-citationOligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton‐Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988 · see citing works
Self-citationNissen, S. E., Tsunoda, T., Tuzcu, E. M., Schoenhagen, P., Cooper, C. J., Yasin, M., Eaton, G. M., Lauer, M. A., Sheldon, W. S., Grines, C. L., et al. (2003) · JAMA · doi:10.1001/jama.290.17.2292 · Cited by 1,707 · see citing works
Huang, X., Jain, P. K., El‐Sayed, I. H., & El‐Sayed, M. A. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.681 · Cited by 1,510 · see citing works
Single-mismatch detection using gold-quenched fluorescent oligonucleotides
Dubertret, B., Calame, M., & Libchaber, A. J. (2001) · Nature Biotechnology · doi:10.1038/86762 · Cited by 1,239 · see citing works
Tardif, J. (2007) · JAMA · doi:10.1001/jama.297.15.jpc70004 · Cited by 724 · see citing works
Biomimetic amplification of nanoparticle homing to tumors
Simberg, D., Duza, T., Park, J. H., Essler, M., Pilch, J., Zhang, L., Derfus, A. M., Yang, M., Hoffman, R. M., Bhatia, S. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610298104 · Cited by 473 · see citing works
Wang, Z., Lee, J. H., & Lu, Y. (2008) · Advanced Materials · doi:10.1002/adma.200703181 · Cited by 445 · see citing works
Antiatherogenic small, dense HDL—guardian angel of the arterial wall?
Kontush, A., & Chapman, M. J. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0500 · Cited by 342 · see citing works
Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform
Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., et al. (2008) · Nano Letters · doi:10.1021/nl801958b · Cited by 328 · see citing works
Beyond High-Density Lipoprotein Cholesterol Levels
deGoma, E. M., deGoma, R. L., & Rader, D. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.016 · Cited by 251 · see citing works
Asztalos, B. F., Sloop, C. H., Wong, L., & Roheim, P. S. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90253-6 · Cited by 235 · see citing works
Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
Silva, R. A. G. D., Huang, R., Morris, J. C., Fang, J., Gracheva, E. O., Ren, G., Kontush, A., Jerome, W. G., Rye, K., & Davidson, W. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803626105 · Cited by 206 · see citing works
Laboratory Assessment of HDL Heterogeneity and Function
Movva, R., & Rader, D. J. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.101923 · Cited by 187 · see citing works
Is raising HDL a futile strategy for atheroprotection?
JOY, T. R., & Hegele, R. A. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2489 · Cited by 135 · see citing works
Three-dimensional models of HDL apoA-I: implications for its assembly and function
Thomas, M. J., Bhat, S., & Sorci‐Thomas, M. G. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800010-jlr200 · Cited by 107 · see citing works
Novel Changes in Discoidal High Density Lipoprotein Morphology: A Molecular Dynamics Study
Catte, A., Patterson, J. C., Jones, M. K., Jerome, W. G., Bashtovyy, D., Su, Z., Gu, F., Chen, J., Aliste, M. P., Harvey, S. C., et al. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.071456 · Cited by 95 · see citing works
Mukherjee, S., & Chattopadhyay, A. (1996) · Biochemistry · doi:10.1021/bi951953q · Cited by 93 · see citing works
Conformational Adaptation of Apolipoprotein A-I to Discretely Sized Phospholipid Complexes
Bhat, S., Sorci‐Thomas, M. G., Tuladhar, R., Samuel, M. P., & Thomas, M. J. (2007) · Biochemistry · doi:10.1021/bi700384t · Cited by 67 · see citing works
Evaluation au laboratoire de l’hétérogénéité et des fonctions des HDL (version française)
Movva, R., & Rader, D. J. (2008) · Annales de biologie clinique · doi:10.1684/abc.2008.0284 · Cited by 59 · see citing works
Pucadyil, T. J., Mukherjee, S., & Chattopadhyay, A. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp066092h · Cited by 59 · see citing works
Transcription Inhibition Using Oligonucleotide-Modified Gold Nanoparticles
Agbasi-Porter, C., Ryman-Rasmussen, J. P., Franzen, S., & Feldheim, D. L. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060100f · Cited by 37 · see citing works
Formation of new HDL particles from lipid-free apolipoprotein A-I.
Clay, M. A., & Barter, P. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39115-x · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356 · see citing works
Self-citationMonolayer coated gold nanoparticles for delivery applications
Rana, S., Bajaj, A., Mout, R., & Rotello, V. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.08.006 · Cited by 482 · see citing works
More Effective Nanomedicines through Particle Design
Wang, J., Byrne, J. D., Napier, M. E., & DeSimone, J. M. (2011) · Small · doi:10.1002/smll.201100442 · Cited by 474 · see citing works
Receptor-targeted nanocarriers for therapeutic delivery to cancer
Yu, B., Tai, H.-C., Xue, W., Lee, L. J., & Lee, R. J. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.521200 · Cited by 425 · see citing works
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles
Kuai, R., Li, D., Chen, Y. E., Moon, J. J., & Schwendeman, A. A. (2016) · ACS Nano · doi:10.1021/acsnano.5b07522 · Cited by 341 · see citing works
Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles
Gunawan, C., Lim, M., Marquis, C. P., & Amal, R. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21526a · Cited by 278 · see citing works
Plasmon‐Mediated Synthesis of Silver Triangular Bipyramids
Zhang, J., Li, S., Wu, J., Schatz, G. C., & Mirkin, C. A. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200903380 · Cited by 169 · see citing works
Self-citationRecent Advancement in mRNA Vaccine Development and Applications
Fayez, N. A., Nassar, M. S., Alshehri, A. A., Alnefaie, M. K., Almughem, F. A., Alshehri, B. Y., Alawad, A. O., & Tawfik, E. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071972 · Cited by 177 · see citing works
Gold nanoparticles as computerized tomography (CT) contrast agents
Xi, D., Dong, S., Meng, X., Lu, Q., Meng, L., & Ye, J. (2012) · RSC Advances · doi:10.1039/c2ra21263c · Cited by 159 · see citing works
Injectable nanomaterials for drug delivery: Carriers, targeting moieties, and therapeutics
Webster, D. M., Sundaram, P., & Byrne, M. E. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.12.009 · Cited by 145 · see citing works
Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis
Marrache, S., & Dhar, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301929110 · Cited by 143 · see citing works
Goldnanopartikel in Biologie und Medizin
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie · doi:10.1002/ange.200904359 · Cited by 137 · see citing works
Self-citationLipoproteins and lipoprotein mimetics for imaging and drug delivery
Thaxton, C. S., Rink, J. S., Naha, P. C., & Cormode, D. P. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.020 · Cited by 137 · see citing works
Self-citationBiomimetic, synthetic HDL nanostructures for lymphoma
Yang, S., Damiano, M. G., Zhang, H., Tripathy, S., Luthi, A. J., Rink, J. S., Ugolkov, A. V., Singh, A. T. K., Davé, S. S., Gordon, L. I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213657110 · Cited by 132 · see citing works
Self-citationBiomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery
McMahon, K. M., Mutharasan, R. K., Tripathy, S., Veliceasa, D., Bobeica, M., Shumaker, D. K., Luthi, A. J., Helfand, B. T., Ardehali, H., Mirkin, C. A., et al. (2011) · Nano Letters · doi:10.1021/nl1041947 · Cited by 124 · see citing works
Self-citationTemplated high density lipoprotein nanoparticles as potential therapies and for molecular delivery
Damiano, M. G., Mutharasan, R. K., Tripathy, S., McMahon, K. M., & Thaxton, C. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.013 · Cited by 117 · see citing works
Self-citationLu, Y., Cui, X., Zhang, L., Wang, X., Xu, Y., Qin, Z., Liu, G., Wang, Q., Tian, K., Lim, K. S., et al. (2022) · Aging and Disease · doi:10.14336/ad.2021.0929 · Cited by 114 · see citing works
Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy
Dhas, N. L., García, M. C., Kudarha, R. R., Pandey, A. P., Nikam, A. N., Gopalan, D., Fernandes, G. J., Soman, S., Kulkarni, S., Seetharam, R. N., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.04.019 · Cited by 110 · see citing works
Gold nanoparticles for regulation of cell function and behavior
Bodelón, G., Costas, C., Pérez‐Juste, J., Pastoriza‐Santos, I., & Liz‐Marzán, L. M. (2017) · Nano Today · doi:10.1016/j.nantod.2016.12.014 · Cited by 107 · see citing works
Inorganic-Organic Hybrid Nanomaterials for Therapeutic and Diagnostic Imaging Applications
Vivero-Escoto, J. L., & Huang, Y. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12063888 · Cited by 102 · see citing works
Membrane mimetic surface functionalization of nanoparticles: Methods and applications
Weingart, J., Vabbilisetty, P., & Sun, X. (2013) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2013.04.003 · Cited by 96 · see citing works
Zanoni, P., Velagapudi, S., Yalçınkaya, M., Rohrer, L., & von Eckardstein, A. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.881 · Cited by 92 · see citing works
Toward greener synthesis of gold nanomaterials: From biological to biomimetic synthesis
Nasaruddin, R. R., Chen, T., Yao, Q., Zang, S., & Xie, J. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213540 · Cited by 94 · see citing works
Plebanek, M. P., Mutharasan, R. K., Volpert, O. V., Matov, A., Gatlin, J. C., & Thaxton, C. S. (2015) · Scientific Reports · doi:10.1038/srep15724 · Cited by 89 · see citing works
Self-citationScavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells
Plebanek, M. P., Bhaumik, D., Bryce, P. J., & Thaxton, C. S. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0981 · Cited by 80 · see citing works
Self-citationYu, X., Feizpour, A., Ramirez, N.-G. P., Wu, L., Akiyama, H., Xu, F., Gummuluru, S., & Reinhard, B. M. (2014) · Nature Communications · doi:10.1038/ncomms5136 · Cited by 77 · see citing works
Hybrid lipid–nanoparticle complexes for biomedical applications
Vargas, K. M., & Shon, Y. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03084g · Cited by 76 · see citing works
Learning from biology: synthetic lipoproteins for drug delivery
Huang, H., Cruz, W., Chen, J., & Zheng, G. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1308 · Cited by 75 · see citing works
Zhao, Y., Imura, T., Leman, L. J., Curtiss, L. K., Maryanoff, B. E., & Ghadiri, M. R. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404714a · Cited by 74 · see citing works
Luthi, A. J., Zhang, H., Kim, D., Giljohann, D. A., Mirkin, C. A., & Thaxton, C. S. (2011) · ACS Nano · doi:10.1021/nn2035457 · Cited by 72 · see citing works
Self-citationHDL as a drug and nucleic acid delivery vehicle
Lacko, A. G., Sabnis, N. A., Nagarajan, B., & McConathy, W. J. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00247 · Cited by 72 · see citing works
Boushehri, M. A. S., Dietrich, D., & Lamprecht, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060510 · Cited by 71 · see citing works
Skajaa, T., Cormode, D. P., Jarzyna, P. A., Delshad, A., Blachford, C., Barazza, A., Fisher, E. A., Gordon, R. E., Fayad, Z. A., & Mulder, W. J. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.078 · Cited by 69 · see citing works
Synthetic High-Density Lipoprotein-Like Nanoparticles as Cancer Therapy
McMahon, K. M., Foit, L., Angeloni, N. L., Giles, F. J., Gordon, L. I., & Thaxton, C. S. (2015) · Cancer treatment and research · doi:10.1007/978-3-319-16555-4_6 · Cited by 69 · see citing works
Self-citationPhospholipid Membrane Encapsulation of Nanoparticles for Surface-Enhanced Raman Scattering
Ip, S. Y., MacLaughlin, C. M., Gunari, N., & Walker, G. C. (2011) · Langmuir · doi:10.1021/la200212c · Cited by 65 · see citing works
Nanobiotechnology applications of reconstituted high density lipoprotein
Ryan, R. O. (2010) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-8-28 · Cited by 62 · see citing works
Zhang, W., Gu, X. Q., Bai, H., Yang, R., Dong, C.-D., & Liu, J. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.03.011 · Cited by 58 · see citing works
Rink, J. S., Sun, W., Misener, S., Wang, J.-J., Zhang, Z. J., Kibbe, M. R., Dravid, V. P., Venkatraman, S. S., & Thaxton, C. S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18525 · Cited by 57 · see citing works
Self-citationHigh density lipoprotein mimicking nanoparticles for atherosclerosis
Chen, J., Zhang, X., Millican, R. C., Creutzmann, J. E., Martin, S., & Jun, H. (2020) · Nano Convergence · doi:10.1186/s40580-019-0214-1 · Cited by 57 · see citing works
Facile Synthesis of Raman Active Phospholipid Gold Nanoparticles
Tam, N. C. M., Scott, B. M., Voicu, D., Wilson, B. C., & Zheng, G. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100386a · Cited by 55 · see citing works
McMahon, K. M., Plebanek, M. P., & Thaxton, C. S. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201602600 · Cited by 52 · see citing works
Self-citationNandwana, V., Ryoo, S., Kanthala, S., McMahon, K. M., Rink, J. S., Li, Y., Venkatraman, S. S., Thaxton, C. S., & Dravid, V. P. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b05357 · Cited by 54 · see citing works
Self-citationDual-Targeted Synthetic Nanoparticles for Cardiovascular Diseases
Banik, B., Surnar, B., Askins, B. W., Banerjee, M., & Dhar, S. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b19036 · Cited by 54 · see citing works
Luthi, A. J., Lyssenko, N. N., Quach, D., McMahon, K. M., Millar, J. S., Vickers, K. C., Rader, D. J., Phillips, M. C., Mirkin, C. A., & Thaxton, C. S. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m054635 · Cited by 48 · see citing works
Self-citationMei, Y., Tang, L., Xiao, Q., Zhang, Z., Zhang, Z., Zang, J., Zhou, J., Wang, Y., Wang, W., & Ren, M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02139c · Cited by 49 · see citing works
Plasmon‐Mediated Synthesis of Silver Triangular Bipyramids
Zhang, J., Li, S., Wu, J., Schatz, G. C., & Mirkin, C. A. (2009) · Angewandte Chemie · doi:10.1002/ange.200903380 · Cited by 49 · see citing works
Self-citationRink, J. S., Yang, S., Çen, O., Taxter, T., McMahon, K. M., Misener, S., Behdad, A., Longnecker, R., Gordon, L. I., & Thaxton, C. S. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00710 · Cited by 48 · see citing works
Self-citationNanomaterials for the theranostics of obesity
Li, J., Cha, R., Luo, H., Hao, W., Zhang, Y., & Jiang, X. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119474 · Cited by 48 · see citing works
High-density lipoproteins for the systemic delivery of short interfering RNA
McMahon, K. M., & Thaxton, C. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.866089 · Cited by 42 · see citing works
Self-citationWang, Y., Wu, C. S., Chen, T., Sun, H. R., Cansız, S., Zhang, L., Cui, C., Hou, W., Wu, Y., Wan, S., et al. (2016) · Chemical Science · doi:10.1039/c6sc00066e · Cited by 42 · see citing works
HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
Bell, J. B., Rink, J. S., Eckerdt, F., Clymer, J. R., Goldman, S., Thaxton, C. S., & Platanias, L. C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18100-8 · Cited by 41 · see citing works
Self-citationYu, Y.-B., Lin, C.-L., Li, B., Zhao, P.-X., & Zhang, S.-Y. (2016) · Green Chemistry · doi:10.1039/c6gc00010j · Cited by 30 · see citing works
Immune lipoprotein nanostructures inspired relay drug delivery for amplifying antitumor efficiency
Han, Y., Ding, B., Zhao, Z., Zhang, H., Sun, B., Zhao, Y., Jiang, L., Zhou, J., & Ding, Y. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.016 · Cited by 39 · see citing works
Nanoparticle-siRNA: A Potential Strategy for Ovarian Cancer Therapy?
Aghamiri, S., Fallah-Mehrjardi, K., Shabani, S., Keshavarz‐Fathi, M., Kargar, S., & Rezaei, N. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0379 · Cited by 38 · see citing works
Protein–nanoparticle conjugates as potential therapeutic agents for the treatment of hyperlipidemia
Maximov, V. D., Reukov, V. V., Barry, J., Cochrane, C., & Vertegel, A. A. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/26/265103 · Cited by 37 · see citing works
Zhao, Y., Leman, L. J., Search, D. J., Garcia, R. A., Gordon, D. A., Maryanoff, B. E., & Ghadiri, M. R. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00154 · Cited by 35 · see citing works
Groner, J., Göpferich, A. M., & Breunig, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.034 · Cited by 34 · see citing works
Delbecq, F., Tsujimoto, K., Ogue, Y., Endô, H., & Kawai, T. (2012) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2012.09.029 · Cited by 34 · see citing works
Nanotechnology for synthetic high-density lipoproteins
Luthi, A. J., Patel, P. C., Ko, C. H., Mutharasan, R. K., Mirkin, C. A., & Thaxton, C. S. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.10.006 · Cited by 34 · see citing works
Self-citationWang, Y., Calvert, A. E., Cárdenas, H., Rink, J. S., Nahotko, D. A., Qiang, W., Ndukwe, C. E., Chen, F., Keathley, R., Zhang, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202305212 · Cited by 33 · see citing works
Self-citationChuang, S. T., Cruz, S., & Narayanaswami, V. (2020) · Nanomaterials · doi:10.3390/nano10050906 · Cited by 33 · see citing works
High-density lipoprotein mimetics: promises and challenges
Sviridov, D., & Remaley, A. T. (2015) · Biochemical Journal · doi:10.1042/bj20150832 · Cited by 33 · see citing works
Henrich, S. E., Hong, B. J., Rink, J. S., Nguyen, S. T., & Thaxton, C. S. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b00651 · Cited by 32 · see citing works
Self-citationMackiewicz, M. R., Hodges, H. L., & Reed, S. M. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp911617q · Cited by 31 · see citing works
The NCI Alliance for Nanotechnology in Cancer: achievement and path forward
Ptak, K., Farrell, D. F., Panaro, N. J., Grodzinski, P. A., & Barker, A. D. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.98 · Cited by 29 · see citing works
Synthetic high-density lipoprotein-like nanoparticles for cancer therapy
Foit, L., Giles, F. J., Gordon, L. I., & Thaxton, C. S. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.990889 · Cited by 27 · see citing works
Self-citationHigh-density lipoproteins for therapeutic delivery systems
Mutharasan, R. K., Foit, L., & Thaxton, C. S. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01332a · Cited by 27 · see citing works
Self-citationDressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse
Yu, X., Xu, F., Ramirez, N.-G. P., Kijewski, S. D. G., Akiyama, H., Gummuluru, S., & Reinhard, B. M. (2015) · ACS Nano · doi:10.1021/acsnano.5b00415 · Cited by 27 · see citing works
Smith, M. C., Crist, R. M., Clogston, J. D., & McNeil, S. E. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8589-2 · Cited by 27 · see citing works
Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia
McMahon, K. M., Scielzo, C., Angeloni, N. L., Deiss‐Yehiely, E., Scarfò, L., Ranghetti, P., Ma, S., Kaplan, J. B., Barbaglio, F., Gordon, L. I., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14494 · Cited by 27 · see citing works
Self-citationmRNA vaccine in gastrointestinal tumors: Immunomodulatory effects and immunotherapy
Zhang, A., Ji, Q., Sheng, X., & Wu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115361 · Cited by 26 · see citing works
Angeloni, N. L., McMahon, K. M., Swaminathan, S., Plebanek, M. P., Osman, I., Volpert, O. V., & Thaxton, C. S. (2016) · Scientific Reports · doi:10.1038/srep22915 · Cited by 25 · see citing works
Self-citationRegulating Cholesterol in Tumorigenesis: A Novel Paradigm for Tumor Nanotherapeutics
Wu, H., Wu, X., Zhao, M., Yan, J., Li, C., Zhang, Z., Tang, S., Wang, R., & Fei, W. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s439828 · Cited by 25 · see citing works
Engineering Single Nanopores on Gold Nanoplates by Tuning Crystal Screw Dislocation
Zhai, Y., Zhang, F., Zhang, B., & Gao, X. (2017) · Advanced Materials · doi:10.1002/adma.201703102 · Cited by 25 · see citing works
Pedersbæk, D., Kræmer, M. K., Kempen, P. J., Ashley, J. A., Braesch‐Andersen, S., Andresen, T. L., & Simonsen, J. B. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00552 · Cited by 25 · see citing works
Singh, A., Nandwana, V., Rink, J. S., Ryoo, S., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S., & Dravid, V. P. (2019) · ACS Nano · doi:10.1021/acsnano.9b03727 · Cited by 25 · see citing works
Self-citationMurakami, T., Nakatsuji, H., Morone, N., Heuser, J. E., Ishidate, F., Hashida, M., & Imahori, H. (2014) · ACS Nano · doi:10.1021/nn5024818 · Cited by 23 · see citing works
HDL-AuNPs-BMS Nanoparticle Conjugates as Molecularly Targeted Therapy for Leukemia
Shen, N., Yan, F., Pang, J., Gao, Z., Al‐Kali, A., Haynes, C. L., Litzow, M. R., & Liu, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b01696 · Cited by 23 · see citing works
Gold nanoparticles: An advanced drug delivery and diagnostic tool
Pandey, V., Ganeshpurkar, A., Thakur, A., Sharma, M., Rajpoot, K., Tekade, M., Sreeharsha, N., & Tekade, R. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814455-8.00018-9 · Cited by 23 · see citing works
A systematic review of the biodistribution of biomimetic high-density lipoproteins in mice
Pedersbæk, D., & Simonsen, J. B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.038 · Cited by 23 · see citing works
Structure and intermolecular interactions in spheroidal high-density lipoprotein subpopulations
Malajczuk, C. J., Gandhi, N. S., & Mancera, R. L. (2020) · Journal of Structural Biology X · doi:10.1016/j.yjsbx.2020.100042 · Cited by 23 · see citing works
Gupta, A., Sharma, R., Kuche, K., & Jain, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120272 · Cited by 23 · see citing works
Functional and Selective Bacterial Interfaces Using Cross-Scaffold Gold Binding Peptides
Adams, B. L., Hurley, M. M., Jahnke, J. P., & Stratis‐Cullum, D. N. (2015) · JOM · doi:10.1007/s11837-015-1662-7 · Cited by 22 · see citing works
Oriana, S., Fracassi, A., Archer, C., & Yamakoshi, Y. N. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b01945 · Cited by 20 · see citing works
Targeted Nanotherapies for the Treatment of Surgical Diseases
Morgan, C. E., Wasserman, M. A., & Kibbe, M. R. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001605 · Cited by 20 · see citing works
He, H., Hong, K. W., Liu, L., & Schwendeman, A. A. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1737 · Cited by 18 · see citing works
Applications: Nanobiosystems, Medicine, and Health
Mirkin, C. A., Nel, A. E., & Thaxton, C. S. (2011) · Springer eBooks · doi:10.1007/978-94-007-1168-6_8 · Cited by 17 · see citing works
Self-citationLai, C., Sun, W., Palekar, R. U., Thaxton, C. S., & Schatz, G. C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b12249 · Cited by 17 · see citing works
Self-citationAtherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities
Jiang, F., Zhu, Y., Gong, C., & Wei, X. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190301143952 · Cited by 17 · see citing works
Melemium Hydrogensulfate H3C6N7(NH2)3(HSO4)3 – the First Triple Protonation of Melem
Sattler, A., & Schnick, W. (2010) · Zeitschrift für anorganische und allgemeine Chemie · doi:10.1002/zaac.201000246 · Cited by 16 · see citing works
Lowell, A. N., Qiao, H., Liu, T., Ishikawa, T., Zhang, H., Oriana, S., Wang, M., Ricciotti, E., FitzGerald, G. A., Zhou, R., et al. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300561e · Cited by 16 · see citing works
Lamperis, S. M., McMahon, K. M., Calvert, A. E., Rink, J. S., Vasan, K., Pandkar, M. R., Crentsil, E. U., Chalmers, Z. R., McDonald, N. R., Kosmala, C. J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2502876122 · Cited by 15 · see citing works
Self-citationEngineered rHDL Nanoparticles as a Suitable Platform for Theranostic Applications
Aranda‐Lara, L., Isaac‐Olivé, K., Ocampo‐García, B., Ferro‐Flores, G., González‐Romero, C., Mercado-López, A., García-Marín, R., Santos‐Cuevas, C., Estrada, J. A., & Morales-Ávila, E. (2022) · Molecules · doi:10.3390/molecules27207046 · Cited by 15 · see citing works
An update on synthetic high-density lipoprotein-like nanoparticles for cancer therapy
Henrich, S. E., & Thaxton, C. S. (2019) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2019.1624529 · Cited by 14 · see citing works
Self-citationSynthetic high-density lipoprotein nanoparticles: Good things in small packages
Lavker, R. M., Kaplan, N., McMahon, K. M., Calvert, A. E., Henrich, S. E., Onay, V., Lu, K. Q., Peng, H., & Thaxton, C. S. (2021) · The Ocular Surface · doi:10.1016/j.jtos.2021.03.001 · Cited by 13 · see citing works
Self-citationKeckeis, P., Drabinová, E., Ruiz‐Agudo, C., Avaro, J. T., Glatt, L., Sedlák, M., & Cölfen, H. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808331 · Cited by 12 · see citing works
Research progress of mRNA vaccines for infectious diseases
Zhang, Z., Du, J., Zhang, D., Han, R., Wu, X., & Liang, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-03060-x · Cited by 16 · see citing works
Chen, S.-H., Hsu, Y., Lu, H.-Y., & Ho, J. A. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.08.017 · Cited by 10 · see citing works
Oosterveer, D. M., Versmissen, J., Schinkel, A. F. L., Langendonk, J. G., Mulder, M. T., & Sijbrands, E. J. G. (2010) · Clinical Lipidology · doi:10.2217/clp.10.9 · Cited by 10 · see citing works
- Authors
- Thaxton, C. S., Daniel, W. L., Giljohann, D. A., Thomas, A. D., & Mirkin, C. A.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Mirkin, Chad A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-09
- Volume
- 131
- Issue
- 4
- Pages
- 1384-1385
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC2843502
- OpenAlex
- W2001399280
- Cited by
- 122
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 5
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP1OD000285)
- National Cancer Institute (U54CA119341)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- high-density lipoprotein, biomimetic nanoparticles, cholesterol binding, apolipoprotein A-I, self-assembly, binding affinity
- MeSH terms
- Gold, Lipoproteins, HDL, Microspheres, Stereoisomerism, Water, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
