Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy
Open accessAbstract
Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.
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A significant portion of studies use MRI with contrast agents based on gadolinium, SPIONs, or manganese ions, reflecting the researchers' desire to create platforms potentially applicable in clinical practice.
“A significant portion of the studies use MRI with contrast agents based on gadolinium [70,71], SPIONs [58,63,73,83], or manganese ions [72], reflecting the researchers’ desire to create platforms potentially applicable in clinical practice.”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [73]
In animal models, reduction in amyloid plaque burden, decrease in neuroinflammation and oxidative stress, and improvement in cognitive functions in behavioral tests have been demonstrated.
“In animal models, a reduction in the burden of amyloid plaques [58,68,75], a decrease in neuroinflammation and oxidative stress, as well as an improvement in cognitive functions in behavioral tests [58,64,72,73,83,85] have been demonstrated.”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [73]
Formulations that escaped the endolysosomal compartment accumulated in the cytoplasm in less than 24 h.
“Formulations that escaped the endolysosomal compartment accumulated in the cytoplasm in less than 24 h25,45.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [45]
The intracellular concentration of formulations containing RA was dependent on the initial formulation loading, type of formulation, and type of cell.
“The intracellular concentration of formulations containing RA was dependent on the initial formulation loading, type of formulation, and type of cell25,45.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [45]
Most preclinical tests were performed in mice in the context of regenerative medicine and cancer.
“Most preclinical tests were performed in mice in the context of regenerative medicine45,60,66,68 and cancer22,25,56.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [45]
In this study, the transplantation of nanoparticle-treated NSCs in AD mice improved cognition and memory.
“In this study, the transplantation of nanoparticle-treated NSCs in AD mice improved cognition and memory.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [45]
Nanoparticles have been developed to efficiently deliver ATRA and small interfering RNA to promote NSC differentiation in AD.
“Nanoparticles have been developed to efficiently deliver ATRA and small interfering RNA to promote NSC differentiation in AD45.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [45]
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References 39 · Cited by 116
- Authors
- Zhang, R., Li, Y., Hu, B., Lu, Z., Zhang, J., & Zhang, X.
- Affiliations
- Chinese Academy of Sciences (CN)
- National Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China
- Hebei University (CN)
- Corresponding author
- Zhang, Jinchao
- Zhang, Xin
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2016-05-11
- Volume
- 28
- Issue
- 30
- Pages
- 6345-6352
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2360077602
- Cited by
- 116
- References
- 39
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 18 · 2020: 9 · 2019: 10 · 2018: 17 · 2017: 8 · 2016: 2
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
- ir.ipe.ac.cn
- Licence
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Institute of Process Engineering, CAS Institutional Repository (submittedVersion, cc-by-nc-sa)
- Funders
- National Natural Science Foundation of China (31522023, 51373177, 31470961)
- Chinese Academy of Sciences (YZ201313, XDA09030301‐3)
- Natural Science Foundation of Beijing Municipality (Z141100000214010)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- nanoparticles, siRNA delivery, retinoic acid, neural stem cells, neuronal differentiation, Alzheimer's disease treatment, neuronal loss, memory impairment, stem cell transplantation, traceability
- MeSH terms
- Alzheimer Disease, Animals, Cell Differentiation, Cell Movement, Tretinoin, RNA, Small Interfering, Mice, Nanoparticles, Neural Stem Cells, Drug Liberation
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