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Cited by 386Nanoparticle-Based Drug DeliveryExtracellular vesicles in diseaseAdvanced Drug Delivery Systems

Neutrophil‐Based Drug Delivery Systems

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Chu, Dafeng, Dong, Xinyue, Shi, Xutong, Zhang, Canyang, Wang, Zhenjia·2018·Advanced Materials
DOI 10.1002/adma.201706245PMC PMC6161715
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Abstract

White blood cells (WBCs) are a major component of immunity in response to pathogen invasion. Neutrophils are the most abundant WBCs in humans, playing a central role in acute inflammation induced by pathogens. Adhesion to vasculature and tissue infiltration of neutrophils are key processes in acute inflammation. Many inflammatory/autoimmune disorders and cancer therapies have been found to be involved in activation and tissue infiltration of neutrophils. A promising strategy to develop novel targeted drug delivery systems is the targeting and exploitation of activated neutrophils. Herein, a new drug delivery platform based on neutrophils is reviewed. There are two types of drug delivery systems: neutrophils as carriers and neutrophil‐membrane‐derived nanovesicles. It is discussed how nanoparticles hijack neutrophils in vivo to deliver therapeutics across blood vessel barriers and how neutrophil‐membrane‐derived nanovesicles target inflamed vasculature. Finally, the potential applications of neutrophil‐based drug delivery systems in treating inflammation and cancers are presented.

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  • Upon recruitment, intercellular adhesion molecule-1 on endothelial cells is up-regulated, and integrin β2, macrophage-1 antigen, and lymphocyte function-associated antigen 1 are overexpressed on neutrophil membrane, facilitating transmigration.

    “the proteins including integrin β2, macrophage-1 antigen, and lymphocyte function-associated antigen 1 are overexpressed on the neutrophil membrane, together facilitating the transmigration.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [206]

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Cited by

Sorted by citations

Authors
Chu, D., Dong, X., Shi, X., Zhang, C., & Wang, Z.
Affiliations
  • Washington State University Spokane (US)
  • Department of Pharmaceutical Sciences College of Pharmacy Washington State University Spokane WA 99210 USA
Corresponding author
Wang, Zhenjia
ORCID
Venue
Advanced Materials
Publisher
Wiley
Published
2018-03-26
Volume
30
Issue
22
Pages
e1706245-e1706245
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.201706245
PMC
PMC6161715
OpenAlex
W2791578198
Cited by
386
References
4
Citations by year
2026: 26 · 2025: 61 · 2024: 63 · 2023: 69 · 2022: 44 · 2021: 56 · 2020: 45 · 2019: 16 · 2018: 6
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (RO1GM116823)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
targeted drug delivery, acute inflammation, autoimmune disease, cancer therapy, nanocarriers
MeSH terms
Humans, Inflammation, Neoplasms, Neutrophils, Drug Delivery Systems, Nanoparticles

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