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The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases
Open accessAbstract
Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of different materials and adjustment of their physical and chemical properties, nanoparticles can have diverse effects on the organism and may change the treating paradigm of multiple diseases in the future. More and more results show that nanoparticles can function as immunomodulators and some formulas have been approved for the treatment of inflammation-related diseases. However, our current understanding of the mechanisms that nanoparticles can influence immune responses is still limited, and systemic clinical trials are necessary for the evaluation of their security and long-term effects. This review provides an overview of the recent advances in nanoparticles that can interact with different cellular and molecular components of the immune system and their application in the management of inflammatory diseases, which are caused by abnormal immune reactions. This article focuses on the mechanisms of interaction between nanoparticles and the immune system and tries to provide a reference for the future design of nanotechnology for the treatment of inflammatory diseases. Graphical Abstract
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After modification or stimulation by corresponding factors, smart nanoparticles efficiently aggregate at the target location and release their payloads.
“After modification or stimulation by corresponding factors, these smart nanoparticles efficiently aggregate at the target location and release their payloads, establishing a smart treatment mode.8–12”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [10]
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References 161 · Cited by 219
Metadata
- Authors
- Liu, J., Liu, Z., Pang, Y., & Zhou, H.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Pang, Yan
- Zhou, Huifang
- Venue
- Journal of Nanobiotechnology
- Published
- 2022-03-12
- Volume
- 20
- Issue
- 1
- Pages
- 127-127
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC8917374
- OpenAlex
- W4220914852
- Cited by
- 219
- References
- 161
- Citations by year
- 2026: 60 · 2025: 68 · 2024: 54 · 2023: 30 · 2022: 7
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82071003, 81761168037, 81770960)
- Science and Technology Commission of Shanghai Municipality (20DZ2270800)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- nanoparticles, immune system, immunomodulation, inflammatory diseases, nanomedicine, nanoparticle safety, nanomaterial design
- MeSH terms
- Immune System, Immunotherapy, Drug Delivery Systems, Nanotechnology, Nanoparticles
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