The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Large‐Pore Mesoporous‐Silica‐Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy
Abstract
Reported immunoadjuvants still have many limitations, such as inferior cellular uptake capacity and biocompatibility, overly large particle sizes, single function, and unsatisfactory therapeutic efficacy. Here, large‐pore mesoporous‐silica‐coated upconversion nanoparticles (UCMSs) with a size of less than 100 nm are successfully prepared by a typical silica sol–gel reaction using mesitylene as a pore‐swelling agent and are applied as a novel immunoadjuvant. The obtained UCMSs not only show significantly higher loadings for the photosensitizers merocyanine 540 (MC540), model proteins (chicken ovalbumin (OVA)), and tumor antigens (tumor cell fragment (TF)), but also are successfully employed for highly efficient in vivo vaccine delivery. The prepared UCMSs–MC540–OVA under 980 nm near‐infrared irradiation shows the best synergistic immunopotentiation action, verified by the strongest Th1 and Th2 immune responses and the highest frequency of CD4+, CD8+, and effector‐memory T cells. Additionally, nanovaccines UCMSs–MC540–TF can more effectively inhibit tumor growth and increase the survival of colon cancer (CT26)‐tumor‐bearing BALB/c mice compared with either photodynamic therapy or immunological therapy alone, suggesting the enhanced immunotherapy efficacy and clinical potential of UCMSs as immunoadjuvants for cancer immunotherapy.
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Cites
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Cited by
Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier
Zha, S., Liu, H., Li, H., Li, H., Wong, K.-L., & All, A. H. (2024) · ACS Nano · doi:10.1021/acsnano.3c10674 · Cited by 378
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Self-citationSun, Y., Zhao, D., Wang, G., Wang, Y., Cao, L., Sun, J., Jiang, Q., & He, Z. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.004 · Cited by 250
Nanomaterials: Breaking through the bottleneck of tumor immunotherapy
Kang, Y., & Li, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123159 · Cited by 61
Metadata
- Authors
- Ding, B., Shao, S., Yu, C., Teng, B., Wang, M., Cheng, Z., Wong, K., Ma, P., & Lin, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-11-02
- Volume
- 30
- Issue
- 52
- Pages
- e1802479-e1802479
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2898671650
- Cited by
- 312
- References
- 47
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Large‐Pore Mesoporous‐Silica‐Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy. https://app.cochat.ai/papers/10.1002/adma.201802479
- The paper
- Ding, B., Shao, S., Yu, C., Teng, B., Wang, M., Cheng, Z., Wong, K., Ma, P., & Lin, J. (2018). Large‐Pore Mesoporous‐Silica‐Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy. Advanced Materials. https://doi.org/10.1002/adma.201802479
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