The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect
Abstract
Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnOx nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. MnOx NSs with large mesoporous structures show ultrahigh loading efficiencies for ovalbumin and tumor cell fragment. The combination of ICD via chemodynamic therapy and ferroptosis inductions, as well as antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, the obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal tumor growth and tumor metastasis.
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Cites
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Calreticulin exposure dictates the immunogenicity of cancer cell death
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
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Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy
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Cited by
Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future
Sen, S., Won, M., Levine, M. S., Noh, Y., Sedgwick, A. C., Kim, J. S., Sessler, J. L., & Arambula, J. F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00417d · Cited by 297
Metadata
- Authors
- Ding, B., Zheng, P., Jiang, F., Zhao, Y., Wang, M., Chang, M., Ma, P., & Lin, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-07-13
- Volume
- 59
- Issue
- 38
- Pages
- 16381-16384
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3031986878
- Cited by
- 341
- References
- 44
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ding, B., Zheng, P., Jiang, F., Zhao, Y., Wang, M., Chang, M., Ma, P., & Lin, J. (2020). MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202005111
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