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Cited by 195

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

X‐Ray‐Controlled Generation of Peroxynitrite Based on Nanosized LiLuF4:Ce3+ Scintillators and their Applications for Radiosensitization

Du, Zhen, Zhang, Xiao, Guo, Zhao, Xie, Jiani, Dong, Xinghua, Zhu, Shuang, Du, Jiangfeng, Gu, Zhanjun, Zhao, Yuliang·2018·Advanced Materials
DOI 10.1002/adma.201804046
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Abstract

Peroxynitrite (ONOO−), the reaction product derived from nitric oxide (NO) and superoxide (O 2−•), is a potent oxidizing and nitrating agent that modulates complex biological processes and promotes cell death. Therefore, it can be expected that the overproduction of ONOO− in tumors can be an efficient approach in cancer therapy. Herein, a multifunctional X‐ray‐controlled ONOO− generation platform based on scintillating nanoparticles (SCNPs) and UV‐responsive NO donors Roussin's black salt is reported, and consequently the mechanism of their application in enhanced therapeutic efficacy of radiotherapy is illustrated. Attributed to the radioluminescence and high X‐ray‐absorbing property of SCNPs, the nanocomposite can produce NO and O 2−• simultaneously when excited by X‐ray irradiation. Such simultaneous release of NO and O 2−• ensures the efficient X‐ray‐controlled generation of ONOO− in tumors. Meanwhile, the application of X‐rays as the excitation source can achieve better penetration depth and induce radiotherapy in this nanotherapeutic platform. It is found that the X‐ray‐controlled ONOO−‐generation platform can efficiently improve the radiotherapy efficiency via directly damaging DNA, downregulating the expression of the DNA‐repair enzyme, and overcoming the hypoxia‐associated resistance in radiotherapy. Therefore, this SCNP‐based platform may provide a new combinatorial strategy of ONOO− and radiotherapy to improve cancer treatment.

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Metadata

Authors
Du, Z., Zhang, X., Guo, Z., Xie, J., Dong, X., Zhu, S., Du, J., Gu, Z., & Zhao, Y.
Venue
Advanced Materials
Publisher
Wiley
Published
2018-09-10
Volume
30
Issue
43
Pages
e1804046-e1804046
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.201804046
OpenAlex
W2891598673
Cited by
195
References
9
FWCI
5.85
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: X‐Ray‐Controlled Generation of Peroxynitrite Based on Nanosized LiLuF4:Ce3+ Scintillators and their Applications for Radiosensitization. https://app.cochat.ai/papers/10.1002/adma.201804046
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Du, Z., Zhang, X., Guo, Z., Xie, J., Dong, X., Zhu, S., Du, J., Gu, Z., & Zhao, Y. (2018). X‐Ray‐Controlled Generation of Peroxynitrite Based on Nanosized LiLuF4:Ce3+ Scintillators and their Applications for Radiosensitization. Advanced Materials. https://doi.org/10.1002/adma.201804046

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.