Cited by 278Photochromic and Fluorescence ChemistryNitric Oxide and Endothelin EffectsPhotopolymerization techniques and applications

Light-controlled nitric oxide delivering molecular assemblies

Sortino, Salvatore·2010·Chemical Society Reviews

Abstract

The multiple roles nitric oxide (NO) plays as a bioregulatory, anticancer, antimicrobial and antioxidant agent has triggered an explosive interest in recent years in compounds able to deliver this diatomic radical for therapeutic purposes. A major issue associated with NO donors is the precise control of the NO release, which effect is highly concentration and flux dependent. Light represents a convenient non-invasive on/off trigger to deliver NO on demand since it allows the accurate control of site, timing and dosage. The assembling of NO photodonors through different approaches may lead to intriguing light-responsive molecular constructs including nanostructured films, polymers, gels, nanoparticles and molecular conjugates which exhibit promising potential in view of practical applications. This tutorial review illustrates the recent research from our and other laboratories towards the fabrication of these molecular assemblies, highlighting the logical design and the relevance in the biomedical field. Therefore, this review is aimed to be a source of inspiration for a wide range of scientists belonging to the chemical, materials science and biochemical communities, facing the common challenge of fabricating controllable NO dispensers.

Integrity signals

Registry

Crossref · 10.1039/b908663n

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62 of 62 references verified0 citation errors · 0 not checkable

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Authors
Sortino, S.
Affiliations
University of Catania (IT)
Corresponding author
Sortino, Salvatore
Venue
Chemical Society Reviews
Published
2010
Volume
39
Issue
8
Pages
2903
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
OpenAlex
W2086971976
Cited by
277
References
64
Citations by year
2026: 14 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 22 · 2019: 19 · 2018: 18 · 2017: 22 · 2016: 17 · 2015: 18 · 2014: 11 · 2013: 22 · 2012: 13
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Society Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
Keywords
nitric oxide donors, molecular assembly, nanostructured films, polymers, gels, nanoparticles, on-demand drug delivery, biomedical applications
MeSH terms
Light, Nitric Oxide, Polymers, Drug Delivery Systems, Nanoparticles

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