Light-controlled nitric oxide delivering molecular assemblies
Abstract
The multiple roles nitric oxide (NO) plays as a bioregulatory, anticancer, antimicrobial and antioxidant agent has triggered an explosive interest in recent years in compounds able to deliver this diatomic radical for therapeutic purposes. A major issue associated with NO donors is the precise control of the NO release, which effect is highly concentration and flux dependent. Light represents a convenient non-invasive on/off trigger to deliver NO on demand since it allows the accurate control of site, timing and dosage. The assembling of NO photodonors through different approaches may lead to intriguing light-responsive molecular constructs including nanostructured films, polymers, gels, nanoparticles and molecular conjugates which exhibit promising potential in view of practical applications. This tutorial review illustrates the recent research from our and other laboratories towards the fabrication of these molecular assemblies, highlighting the logical design and the relevance in the biomedical field. Therefore, this review is aimed to be a source of inspiration for a wide range of scientists belonging to the chemical, materials science and biochemical communities, facing the common challenge of fabricating controllable NO dispensers.
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- Authors
- Sortino, S.
- Affiliations
- University of Catania (IT)
- Corresponding author
- Sortino, Salvatore
- ORCID
- Sortino, Salvatore
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 39
- Issue
- 8
- Pages
- 2903
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2086971976
- Cited by
- 277
- References
- 64
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 22 · 2019: 19 · 2018: 18 · 2017: 22 · 2016: 17 · 2015: 18 · 2014: 11 · 2013: 22 · 2012: 13
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Keywords
- nitric oxide donors, molecular assembly, nanostructured films, polymers, gels, nanoparticles, on-demand drug delivery, biomedical applications
- MeSH terms
- Light, Nitric Oxide, Polymers, Drug Delivery Systems, Nanoparticles
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