The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade
Abstract
Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot that can respond to the acidic pH and reactive oxygen species (ROS) within the tumor microenvironment (TME) for codelivery of anti‐PD1 antibody (aPD1) and Zebularine (Zeb), an HMA, is engineered. aPD1 is first loaded into pH‐sensitive calcium carbonate nanoparticles (CaCO 3 NPs), which are then encapsulated in the ROS‐responsive hydrogel together with Zeb (Zeb‐aPD1‐NPs‐Gel). It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice.
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“Accumulating evidence indicates that chemotherapy, radiotherapy, angiogenesis inhibitor, stimulator of interferon genes (STING) agonist, fecal microbiota transplantation (FMT), epigenetic modulators, or other immunomodulators could synergize α-PD-1/PD-L1, by enhancing cancer antigen release, APC function, or effector activity [22–31].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [27]
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Cites
Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Motzer, R. J., Escudier, B., McDermott, D. F., George, S., Hammers, H. J., Srinivas, S., Tykodi, S. S., Sosman, J. A., Procopio, G., Plimack, E. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1510665 · Cited by 5,807
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588
The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
El-Khoueiry, A. B., Sangro, B., Yau, T., Crocenzi, T. S., Kudo, M., Hsu, C., Kim, T.-Y., Choo, S.-P., Trojan, J., Welling, T. H., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31046-2 · Cited by 4,280
Topalian, S. L., Sznol, M., McDermott, D. F., Kluger, H. M., Carvajal, R. D., Sharfman, W. H., Brahmer, J. R., Lawrence, D. P., Atkins, M. B., Powderly, J. D., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.0105 · Cited by 2,222
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
Chen, Q., Xu, L., Liang, C., Wang, C., Peng, R., & Liu, Z. (2016) · Nature Communications · doi:10.1038/ncomms13193 · Cited by 1,612
Self-citationAnti–PD-1/PD-L1 therapy of human cancer: past, present, and future
Chen, L., & Han, X. N. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80011 · Cited by 1,455
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization
Sanmamed, M. F., & Chen, L. (2018) · Cell · doi:10.1016/j.cell.2018.09.035 · Cited by 1,414
Research works printed but not linked: 4
- Héninger E., 2015, Front. Immunol., 6, 29
- Gnyszka A., 2013, Anticancer Res., 33, 2989
- Sasaki M., 2001, Cancer Res., 61, 4809
- Nishiyama N., 2003, Cancer Res., 63, 8977
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Sorted by citations
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445
Translational Applications of Hydrogels
Correa, S., Grosskopf, A. K., Hernandez, H. L., Chan, D. C., Yu, A. C., Stapleton, L. M., & Appel, E. A. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01177 · Cited by 1,174
Calcium carbonate: controlled synthesis, surface functionalization, and nanostructured materials
Niu, Y., Liu, J., Aymonier, C., Fermani, S., Kralj, D., Falini, G., & Zhou, C. H. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00519g · Cited by 435
An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing
Hu, B., Gao, M., Boakye‐Yiadom, K. O., Ho, W., Yu, W., Xu, X., & Zhang, X. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.040 · Cited by 311
Smart Injectable Hydrogels for Cancer Immunotherapy
Chao, Y., Chen, Q., & Liu, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902785 · Cited by 274
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Metadata
- Authors
- Ruan, H., Hu, Q., Wen, D., Chen, Q., Chen, G., Lu, Y., Wang, J., Cheng, H., Lu, W., & Gu, Z.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Bioengineering University of California Los Angeles CA 90095 USA
- Drexel University (US)
- Fudan University (CN)
- Corresponding author
- Lu, Weiyue
- Gu, Zhen
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-03-11
- Volume
- 31
- Issue
- 17
- Pages
- e1806957-e1806957
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2922000375
- Cited by
- 220
- References
- 55
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 31 · 2023: 32 · 2022: 40 · 2021: 38 · 2020: 39 · 2019: 17
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of North Carolina at Chapel Hill
- Alfred P. Sloan Foundation
- National Natural Science Foundation of China (81690263)
- China Scholarship Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- advanced melanoma, epigenetic modulation, zebularine, PD-1/PD-L1 blockade, anti-PD-1, ROS-responsive hydrogel, tumor microenvironment, tumor-associated antigen expression, immunosuppressive tumor microenvironment, combination immunotherapy, B16F10 melanoma
- MeSH terms
- Animals, Antibodies, Monoclonal, Antineoplastic Agents, Calcium Carbonate, Cytidine, Drug Therapy, Combination, Humans, Hydrogen-Ion Concentration, Immunosuppressive Agents, Immunotherapy, Melanoma, Drug Delivery Systems, Reactive Oxygen Species, Cell Line, Tumor, Nanoparticles, Tumor Microenvironment, Programmed Cell Death 1 Receptor, Antibodies, Monoclonal, Humanized, Drug Liberation
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