The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bioorthogonal Coordination Polymer Nanoparticles with Aggregation‐Induced Emission for Deep Tumor‐Penetrating Radio‐ and Radiodynamic Therapy
Abstract
Radiodynamic therapy (RDT), an emerging therapeutic approach for cancer treatment by employing ionizing irradiation to induce localized photodynamic therapy (PDT) can overcome the drawbacks of the limited penetration depth for traditional PDT and the unconcentrated energy in the tumor for traditional radiotherapy (RT). Taking advantage of aggregation‐induced emission (AIE) photosensitizers with bright fluorescence and efficient singlet oxygen production in the aggregate state, Hf‐AIE coordination polymer nanoparticles (CPNs), which show both strong RT and RDT effect under X‐ray irradiation, are developed. Furthermore, to enhance the tumor accumulation and prolong the tumor retention of the CPNs, bioorthogonal click chemistry is applied in the system through coupling between dibenzocyclooctyne (DBCO)‐modified CPNs (Hf‐AIE‐PEG‐DBCO) (PEG: poly(ethylene glycol)) and azide groups on the cell membrane formed by metabolic glycoengineering. Thanks to the high penetration of X‐ray irradiation, the bioorthogonal‐assisted RT and RDT combination therapy realizes significant killing of cancer cells without showing noticeable biotoxicity after intravenous administration of CPNs.
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Citations
Cites
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
O’Connor, A. E., Gallagher, W. M., & Byrne, A. T. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00585.x · Cited by 1,191
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Self-citation
Cited by
Feng, L., Li, C., Liu, L., Wang, Z., Chen, Z., Yu, J., Ji, W., Jiang, G., Zhang, P., Wang, J., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c10019 · Cited by 268
The Current Status of Photodynamic Therapy in Cancer Treatment
Jiang, W., Liang, M., Lei, Q., Li, G., & Wu, S. (2023) · Cancers · doi:10.3390/cancers15030585 · Cited by 268
Research progress on nano-sensitizers for enhancing the effects of radiotherapy
Zhang, Y., Han, X., Liu, Y., Wang, S., Han, X., & Cheng, C. (2022) · Materials Advances · doi:10.1039/d2ma00094f · Cited by 44
Nanoscale Mixed-Ligand Metal–Organic Framework for X-ray Stimulated Cancer Therapy
Zhen, W., Xu, Z., Mao, Y., McCleary, C., Jiang, X., Weichselbaum, R. R., & Lin, W. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12140 · Cited by 37
Metadata
- Authors
- Liu, J., Hu, F., Wu, M., Tian, L., Gong, F., Zhong, X., Chen, M., Liu, Z., & Liu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2021-01-25
- Volume
- 33
- Issue
- 9
- Pages
- e2007888-e2007888
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W3121600637
- Cited by
- 164
- References
- 3
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, J., Hu, F., Wu, M., Tian, L., Gong, F., Zhong, X., Chen, M., Liu, Z., & Liu, B. (2021). Bioorthogonal Coordination Polymer Nanoparticles with Aggregation‐Induced Emission for Deep Tumor‐Penetrating Radio‐ and Radiodynamic Therapy. Advanced Materials. https://doi.org/10.1002/adma.202007888
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