The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT
Abstract
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy of acceptor planarization and donor rotation is proposed to design type I photosensitizers (PSs) and photothermal reagents. Acceptor planarization can not only enforce intramolecular charge transfer to redshift NIR absorption but also transfer the type of PSs from type II to type I photochemical pathways. Donor rotation optimizes photothermal conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, and 2TPEVDPP, with different number of rotors were prepared. Experimental results showed that three compounds were excellent type I PSs, and the corresponding 2TPEVDPP nanoparticles (NPs) with the most rotors possessed the highest PCE. The photophysical properties of 2TPEVDPP NPs are particularly suitable for in vivo NIR fluorescence imaging-guided synergistic PDT/PTT therapy. The proposed strategy is helpful for exploiting type I phototherapeutic reagents with high efficacy for synergistic PDT and PTT.
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Cites
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Self-citationReactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
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Nanotechnology for Multimodal Synergistic Cancer Therapy
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The microbiome, cancer, and cancer therapy
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Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
Liu, Y., Ran, X., Zhou, D., Zhang, H., Chen, Y., Xu, J., Chen, S., Kong, Q., Yu, X., & Li, K. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202311365 · Cited by 69
Li, M., Lu, Z., Zhang, J., Chen, L., Tang, X., Jiang, Q., Hu, Q., Li, L., Liu, J., & Huang, W. (2023) · Advanced Materials · doi:10.1002/adma.202209647 · Cited by 56
Metadata
- Authors
- Feng, L., Li, C., Liu, L., Wang, Z., Chen, Z., Yu, J., Ji, W., Jiang, G., Zhang, P., Wang, J., & Tang, B. Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-03-01
- Volume
- 16
- Issue
- 3
- Pages
- 4162-4174
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4214510983
- Cited by
- 268
- References
- 63
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feng, L., Li, C., Liu, L., Wang, Z., Chen, Z., Yu, J., Ji, W., Jiang, G., Zhang, P., Wang, J., & Tang, B. Z. (2022). Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT. ACS Nano. https://doi.org/10.1021/acsnano.1c10019
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