A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca2+‐Overload‐Enhanced Catalytic Tumor Nanotherapy

Dong, Caihong; Dai, Xinyue; Wang, Xi; Lu, Qing; Chen, Liang; Song, Xinran; Ding, Li; Huang, Hui; Feng, Wei; Chen, Yu; Chang, Meiqi

doi:10.1002/adma.202205680

Cited by 130Advanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

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A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca2+‐Overload‐Enhanced Catalytic Tumor Nanotherapy

Dong, Caihong, Dai, Xinyue, Wang, Xi, Lu, Qing, Chen, Liang, Song, Xinran, Ding, Li, Huang, Hui, Feng, Wei, Chen, Yu, Chang, Meiqi·2022·Advanced Materials

DOI 10.1002/adma.202205680

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Abstract

The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation of reactive oxygen species (ROS) caused by the valence change of metal elements. However, very little research is focused on and has achieved the exploration and development of enzyme‐mimicking activities of valence‐invariable metal compounds. Herein, a distinct valence‐invariable calcium fluoride (CaF 2) nanozyme with ultrasound (US)‐enhanced peroxidase (POD)‐mimicking activity is rationally designed and engineered for efficient calcium (Ca 2+)‐overload‐enhanced catalytic tumor nanotherapy, which is the first paradigm of Ca‐based nanozymes for catalytic cancer treatment. The release of exogenous Ca 2+ ions from CaF 2 nanocrystals and deleterious ROS generation derived from US‐amplified POD‐mimicking properties facilitate intracellular Ca 2+ accumulation and achieve Ca 2+‐overload‐induced mitochondrial dysfunction through introducing exogenous Ca 2+ ions and regulating calcium‐pumping channels of neoplastic cells. Especially, US as an exogenous energy input is capable of substantially amplifying POD‐mimicking catalytic activities of CaF 2 nanozyme, ultimately achieving efficient anti‐neoplastic outcome on both 4T1 breast tumor and H22 hepatic carcinoma animal models. Such a discovery of enzyme‐like activity of valence‐invariable metal compounds can broaden the cognition scope of nanozymes and effectively serves the field of catalytic and chemoreactive nanomedicine.

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Authors: Dong, C., Dai, X., Wang, X., Lu, Q., Chen, L., Song, X., Ding, L., Huang, H., Feng, W., Chen, Y., & Chang, M.
Affiliations: Shanghai Medical College of Fudan University (CN)
Shanghai University (CN)
Tongji University (CN)
Shanghai University of Traditional Chinese Medicine (CN)
Corresponding author: Lu, Qing
Chen, Yu
Chang, Meiqi
ORCID: Dong, Caihong
Dai, Xinyue
Wang, Xi
Chen, Liang
Song, Xinran
Ding, Li
Feng, Wei
Chen, Yu
Chang, Meiqi
Venue: Advanced Materials
Publisher: Wiley
Published: 2022-09-26
Volume: 34
Issue: 43
Pages: e2205680-e2205680
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.202205680
OpenAlex: W4295906996
Cited by: 130
References: 35
Citations by year: 2026: 26 · 2025: 35 · 2024: 49 · 2023: 20
FWCI: 7.31
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: peroxidase-like activity, calcium overload, intracellular calcium accumulation, mitochondrial dysfunction, reactive oxygen species generation, cancer nanotherapy, breast cancer, hepatocellular carcinoma, calcium ion release
MeSH terms: Animals, Antioxidants, Calcium, Calcium Fluoride, Catalysis, Peroxidase, Neoplasms, Peroxidases, Reactive Oxygen Species

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A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca2+‐Overload‐Enhanced Catalytic Tumor Nanotherapy

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