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Engineering Large‐Scale Self‐Mineralizing Bone Organoids with Bone Matrix‐Inspired Hydroxyapatite Hybrid Bioinks (Adv. Mater. 30/2024)
Open accessAbstract
Bone Organoids Bone organoids serve as innovative tools in biomedical research, enhancing our understanding of bone biology and related diseases. Current bone organoid research is still in its infancy. In article number 2309875, Jiacan Su and co-workers present a novel approach using bone matrix-inspired hydroxyapatite hybrid bioinks to fabricate large-scale self-mineralizing bone organoids via bioprinting. These miniature, self-organizing structures mimic the complexity of bone tissue.
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Repair of large-sized bone defects resulting from severe injury, open fractures, bacterial infections, tumor resection, or congenital genetic disorders constitutes a global clinical challenge.
“Repair of large-sized bone defects resulting from severe injury, open fractures, bacterial infections, tumor resection, or congenital genetic disorders constitutes a global clinical challenge [[1], [2], [3]].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [2]
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Metadata
- Authors
- Wang, J., Wu, Y., Li, G., Zhou, F., Wu, X., Wang, M., Liu, X., Tang, H., Bai, L., Geng, Z., Song, P., Shi, Z., Ren, X., & Su, J.
- Affiliations
- Shanghai University (CN)
- Xi'an Honghui Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2024-07
- Volume
- 36
- Issue
- 30
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4400986798
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advanced Materials (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- bone organoids, hydroxyapatite, bioinks, bioprinting, bone matrix, 3D bioprinting, bone tissue engineering
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