The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals
Abstract
Mechanochemical reactions by milling, grinding or other types of mechanical action have emerged as a salient green approach because of its wide applications towards academic and industrial chemical communities in sustainable solvent‐free/solvent‐less processes. Liquid‐assisted grinding (LAG) as an extension of traditional solvent‐free mechanochemical techniques by which a small amount of liquid is used as an additive to enhance and/or control reactivity, has been fruitfully applied in the screening of inclusion compounds, cocrystals, salts, solvates, and polymorphs. However, utilization of this important technique in the synthesis of pharmaceutically and biologically relevant targets was not adequately investigated. This review article summarizes an overview of the latest development of LAG mechanochemical approaches in the synthesis of active pharmaceutical ingredients (API) and drug‐like fragments, highlights its superiority versus conventional syntheses. magnified image
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Cites
Privileged scaffolds for library design and drug discovery
Welsch, M. E., Snyder, S. A., & Stockwell, B. R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.018 · Cited by 1,509
Perspective on Solvent Use in the Pharmaceutical Industry
Constable, D. J. C., Jimenez-Gonzalez, C., & Henderson, R. K. (2007) · Organic Process Research & Development · doi:10.1021/op060170h · Cited by 744
The greening of peptide synthesis
Lawrenson, S. B., Arav, R., & North, M. (2017) · Green Chemistry · doi:10.1039/c7gc00247e · Cited by 205
Cited by
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Cuccu, F., De Luca, L., Delogu, F., Colacino, E., Solin, N., Mocci, R., & Porcheddu, A. (2022) · ChemSusChem · doi:10.1002/cssc.202200362 · Cited by 339
Kekessie, I., Wegner, K., Martinez, I., Kopach, M. E., White, T. D., Tom, J. K., Kenworthy, M. N., Gallou, F., Lopez, J., Koenig, S. G., et al. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c01494 · Cited by 149
Metadata
- Authors
- Ying, P., Yu, J., & Su, W.
- Venue
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Published
- 2021-02
- Volume
- 363
- Issue
- 5
- Pages
- 1246-1271
- ISSN
- 1615-4150 (ISSN-L)
- 1615-4169
- OpenAlex
- W3122528099
- Cited by
- 368
- References
- 3
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- closed
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