CoChat
Sign Up
Cited by 928Hydrogels: synthesis, properties, applicationsPolymer Nanocomposite Synthesis and IrradiationPolymer Nanocomposites and Properties

Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials

Open access
Thoniyot, Praveen, Tan, Mein Jin, Karim, Anis Abdul, Young, David James, Loh, Xian Jun·2015·Advanced Science
DOI 10.1002/advs.201400010PMC PMC5115280
Open this paper in CoChat — free account

Abstract

New technologies rely on the development of new materials, and these may simply be the innovative combination of known components. The structural combination of a polymer hydrogel network with a nanoparticle (metals, non-metals, metal oxides, and polymeric moieties) holds the promise of providing superior functionality to the composite material with applications in diverse fields, including catalysis, electronics, bio-sensing, drug delivery, nano-medicine, and environmental remediation. This mixing may result in a synergistic property enhancement of each component: for example, the mechanical strength of the hydrogel and concomitantly decrease aggregation of the nanoparticles. These mutual benefits and the associated potential applications have seen a surge of interest in the past decade from multi-disciplinary research groups. Recent advances in nanoparticle-hydrogel composites are herein reviewed with a focus on their synthesis, design, potential applications, and the inherent challenges accompanying these exciting materials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/advs.201400010

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 88

  1. [1]O. Wichterle, D. Lim, Nature 1960, 185, 117.
  2. [2]a) O. A. S. X. J. Loh, Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, Royal Society of Chemistry Publishing, 2013; b) E. A. Appel, J. del Barrio, X. J. Loh, O. A. Scherman, Chem. Soc. Rev. 2012, 41, 6195; 22890548 c) I. Tokarev, S. Minko, Soft Matter 2009, 5, 511.
  3. [4]a) Y. Liu, H. Meng, S. Konst, R. Sarmiento, R. Rajachar, B. P. Lee, ACS Appl. Mater. Interfaces 2014, 6, 16982; 25222290 PMC4189622 b) S. Skelton, M. Bostwick, K. O'Connor, S. Konst, S. Casey, B. P. Lee, Soft Matter 2013, 9, 3825.
  4. [5]G. Marcelo, M. López‐González, F. Mendicuti, M. P. Tarazona, M. Valiente, Macromolecules 2014, 47, 6028.
  5. [6]V. Pardo‐Yissar, R. Gabai, A. N. Shipway, T. Bourenko, I. Willner, Adv. Mater. 2001, 13, 1320.
  6. [7]C. Wang, N. T. Flynn, R. Langer, Adv. Mater. 2004, 16, 1074.
  7. [8]N. S. Satarkar, D. Biswal, J. Z. Hilt, Soft Matter 2010, 6, 2364.
  8. [9]P. Schexnailder, G. Schmidt, Colloid Polym. Sci. 2009, 287, 1.
  9. [10]A. K. Gaharwar, N. A. Peppas, A. Khademhosseini, Biotechnol.Bioeng. 2014, 111, 441. 24264728 PMC3924876
  10. [11]S. R. Sershen, S. L. Westcott, N. J. Halas, J. L. West, Appl. Phys. Lett. 2002, 80, 4609.
  11. [12]N. Ravi, H. A. Aliyar, P. D. Hamilton, Macromol. Symp. 2005, 227, 191.
  12. [13]J. M. Weissman, H. B. Sunkara, A. S. Tse, S. A. Asher, Science 1996, 274, 959. 8875932
  13. [14]a) J. H. Holtz, S. A. Asher, Nature 1997, 389, 829; 9349814 b) Y. Xia, P. Yang, Y. Sun, Y. Wu, B. Mayers, B. Gates, Y. Yin, F. Kim, H. Yan, Adv. Mater. 2003, 15, 353; c) S. R. Sershen, S. L. Westcott, N. J. Halas, J. L. West, J. Biomed. Mater. Res. 2000, 51, 293. 10880069
  14. [15]M. Liu, Y. Ishida, Y. Ebina, T. Sasaki, T. Aida, Nat. Commun. 2013, 4. 23774219
  15. [16]L. Sheeney‐Haj‐Ichia, G. Sharabi, I. Willner, Adv. Funct. Mater. 2002, 12, 27.
  16. [17]Guo, J.‐S. Hu, H.‐P. Liang, L.‐J. Wan, C.‐L. Bai, Chem. Mater. 2003, 15, 4332.
  17. [18]C. D. Jones, L. A. Lyon, J. Am. Chem. Soc. 2002, 125, 460. 12517159
  18. [19]P. Saravanan, M. Padmanabha Raju, S. Alam, Mater. Chem. Phys. 2007, 103, 278.
  19. [20]P. S. K. Murthy, Y. Murali Mohan, K. Varaprasad, B. Sreedhar, K. Mohana Raju, J. Colloid Interface Sci. 2008, 318, 217. 18005980
  20. [21]Y. Xiang, D. Chen, Eur. Polym. J. 2007, 43, 4178.
  21. [22]K. Varaprasad, G. Siva Mohan Reddy, J. Jayaramudu, R. Sadiku, K. Ramam, S. S. Ray, Biomater. Sci. 2014, 2, 257. 32481885
  22. [23]R. S. Glauco, R. C. Dawn, I. S. Fernanda, G. O. Michael, Y. S. Evan, L. S. Richard, J. H. Miller, A. Wadih, P. Renata, Proc. Natl. Acad. Sci. US A 2006, 103, 1215.
  23. [24]L. Castaneda, J. Valle, N. Yang, S. Pluskat, K. Slowinska, Biomacromolecules 2008, 9, 3383. 18959440 PMC2741184
  24. [25]X. Zhao, X. Ding, Z. Deng, Z. Zheng, Y. Peng, C. Tian, X. Long, N. J. Chem. 2006, 30, 915.
  25. [26]A. Skardal, J. Zhang, L. McCoard, S. Oottamasathien, G. D. Prestwich, Adv. Mater. 2010, 22, 4736. 20730818
  26. [27]D. Zhang, J. Yang, S. Bao, Q. Wu, Q. Wang, Sci. Rep. 2013, 3, 1399. 23466566 PMC3590559
  27. [28]S. Rose, A. Prevoteau, P. Elziere, D. Hourdet, A. Marcellan, L. Leibler, Nature 2014, 505, 382. 24336207
  28. [29]H. Wu, G. Yu, L. Pan, N. Liu, M. T. McDowell, Z. Bao, Y. Cui, Nat. Commun. 2013, 4, 1943. 23733138
  29. [30]L. S. Nair, C. T. Laurencin, J. Biomedical Nanotechnology 2007, 3, 301– 316.
  30. [31]H. Barani, M. Montazer, N. Samadi, T. Toliyat, Colloids Surf. B: Biointerfaces 2012, 92, 9. 22178185
  31. [32]M. Moritz, M. Geszke‐Moritz, Chem. Eng. J. 2013, 228, 596.
  32. [33]K. Vimala, K. Samba Sivudu, Y. Murali Mohan, B. Sreedhar, K. Mohana Raju, Carbohydr. Polym. 2009, 75, 463.
  33. [34]G. R. Bardajee, Z. Hooshyar, H. Rezanezhad, J. Inorg. Biochem. 2012, 117, 367. 22818024
  34. [35]Y. Murali Mohan, K. Lee, T. Premkumar, K. E. Geckeler, Polymer 2007, 48, 158.
  35. [36]Q.‐B. Wei, F. Fu, Y.‐Q. Zhang, L. Tang, J. Polym. Res. 2014, 21, 1.
  36. [37]K. A. Juby, C. Dwivedi, M. Kumar, S. Kota, H. S. Misra, P. N. Bajaj, Carbohydr. Polym. 2012, 89, 906. 24750879
  37. [38]R.‐C. Luo, Z. H. Lim, W. Li, P. Shi, C.‐H. Chen, Chem. Commun. 2014, 50, 7052. 24849317
  38. [39]Y.‐Q. Ma, J.‐Z. Yi, L.‐M. Zhang, J. Macromol. Sci., Part A: Pure Appl. Chem. 2009, 46, 643.
  39. [40]H. L. Abd El‐Mohdy, J. Polym. Res. 2013, 20, 1.
  40. [41]I. Tokarev, I. Tokareva, V. Gopishetty, E. Katz, S. Minko, Adv. Mater. 2010, 22, 1412. 20333690
  41. [42]T. Endo, R. Ikeda, Y. Yanagida, T. Hatsuzawa, Anal. Chim. Acta 2008, 611, 205. 18328322
  42. [43]E. S. Abdel‐Halim, S. S. Al‐Deyab, Int. J. Biol. Macromol. 2014, 69, 456. 24928058
  43. [44]J.‐O. You, D. T. Auguste, Langmuir 2010, 26, 4607. 20199077
  44. [45]J. Wang, S. Banerji, N. Menegazzo, W. Peng, Q. Zou, K. S. Booksh, Talanta 2011, 86, 133. 22063522
  45. [46]E. Marsich, A. Travan, I. Donati, A. Di Luca, M. Benincasa, M. Crosera, S. Paoletti, Colloids Surf. B: Biointerfaces 2011, 83, 331. 21186099
  46. [47]A. G. Skirtach, C. Dejugnat, D. Braun, A. S. Susha, A. L. Rogach, W. J. Parak, H. Möhwald, G. B. Sukhorukov, Nano Lett. 2005, 5, 1371. 16178241
  47. [48]A. Shiotani, T. Mori, T. Niidome, Y. Niidome, Y. Katayama, Langmuir 2007, 23, 4012. 17311430
  48. [49]S. R. Sershen, M. Ng, N. J. Halas, J. L. West, in Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint, Vol. 3, 2002, p. 1822.
  49. [50]S. R. Sershen, G. A. Mensing, M. Ng, N. J. Halas, D. J. Beebe, J. L. West, Adv. Mater. 2005, 17, 1366. 34412418
  50. [51]I. Maity, D. B. Rasale, A. K. Das, Soft Matter 2012, 8, 5301.
  51. [52]a) R. Fuhrer, E. K. Athanassiou, N. A. Luechinger, W. J. Stark, Small 2009, 5, 383; 19180549 b) V. Thiruvengadam, S. Vitta, RSC Adv. 2013, 3, 12765.
  52. [53]W. Shi, K. Crews, N. Chopra, Mater. Technol. 2010, 25, 149.
  53. [54]S. Cometa, R. Iatta, M. A. Ricci, C. Ferretti, E. De Giglio, J. Bioact. Compat. Polym. 2013, 28, 508.
  54. [55]S. R. Shirsath, A. P. Hage, M. Zhou, S. H. Sonawane, M. Ashokkumar, Desalination 2011, 281, 429.
  55. [56]N. Sahiner, O. Ozay, N. Aktas, E. Inger, J. He, Int. J. Hydrogen Energy 2011, 36, 15250.
  56. [57]L. Zhang, S. Zheng, D. E. Kang, J. Y. Shin, H. Suh, I. Kim, RSC Adv. 2013, 3, 4692.
  57. [58]A. L. Daniel‐da‐Silva, R. S. Carvalho, T. Trindade, Recent Pat. Nanotechnol. 2013, 7, 153. 23763267
  58. [59]A. Tiwari, N. Sharma, J. Dispersion Sci. Technol. 2012, 34, 1437.
  59. [60]O. Korotych, Y. Samchenko, I. Boldeskul, Z. Ulberg, N. Zholobak, L. Sukhodub, Mater. Sci. Eng. C 2013, 33, 892. 25427503
  60. [61]N. Sahiner, O. Ozay, N. Aktas, Chemosphere 2011, 85, 832. 21764103
  61. [62]H. Yan, L. Yang, Z. Yang, H. Yang, A. Li, R. Cheng, J. Hazardous Mater. 2012, 229–230, 371. 22749139
  62. [63]P. C. Papaphilippou, A. Pourgouris, O. Marinica, A. Taculescu, G. I. Athanasopoulos, L. Vekas, T. Krasia‐Christoforou, J. Magn. Magn. Mater. 2011, 323, 557.
  63. [64]O. Ozay, S. Ekici, Y. Baran, N. Aktas, N. Sahiner, Water Res. 2009, 43, 4403. 19625066
  64. [65]O. Ozay, S. Ekici, Y. Baran, S. Kubilay, N. Aktas, N. Sahiner, Desalination 2010, 260, 57.
  65. [66]T. Caykara, D. Yörük, S. Demirci, J. Appl. Polym. Sci. 2009, 112, 800.
  66. [67]N. S. Satarkar, J. Z. Hilt, J. Controlled Release 2008, 130, 246. 18606201
  67. [68]a) C. R. van den Brom, I. Anac, R. F. Roskamp, M. Retsch, U. Jonas, B. Menges, J. A. Preece, J. Mater. Chem. 2010, 20, 4827; b) Q. Wang, R. Hou, Y. Cheng, J. Fu, Soft Matter 2012, 8, 6048.
  68. [69]J. Yang, C. R. Han, J. F. Duan, F. Xu, R. C. Sun, Nanoscale 2013, 5, 10858. 24089085
  69. [70]X. Hu, X. Hao, Y. Wu, J. Zhang, X. Zhang, P. C. Wang, G. Zou, X.‐J. Liang, J. Mater. Chem. B 2013, 1, 1109. PMC3609667 23543911
  70. [71]G. S. Alvarez, C. Helary, A. M. Mebert, X. Wang, T. Coradin, M. F. Desimone, J. Mater. Chem. B 2014, 2, 4660. 32262278
  71. [72]J. H. Lee, J.‐H. Park, M. Eltohamy, R. Perez, E.‐J. Lee, H.‐W. Kim, RSC Adv. 2013, 3, 24202.
  72. [73]M. Annaka, K. Mortensen, T. Matsuura, M. Ito, K. Nochioka, N. Ogata, Soft Matter 2012, 8, 7185.
  73. [74]S. K. Samanta, A. Pal, S. Bhattacharya, C. N. R. Rao, J. Mater. Chem. 2010, 20, 6881.
  74. [75]C.‐W. Lo, D. Zhu, H. Jiang, Soft Matter 2011, 7, 5604.
  75. [76]C. Ninh, M. Cramer, C. J. Bettinger, Biomater. Sci. 2014, 2, 766. 26828866 PMC5877794
  76. [77]C. Chang, J. Peng, L. Zhang, D.‐W. Pang, J. Mater. Chem. 2009, 19, 7771.
  77. [78]A. Salcher, M. S. Nikolic, S. Casado, M. Velez, H. Weller, B. H. Juarez, J. Mater. Chem. 2010, 20, 1367.
  78. [79]A. O. Moughton, M. A. Hillmyer, T. P. Lodge, Macromolecules 2011, 45, 2.
  79. [80]R. T. Chacko, J. Ventura, J. Zhuang, S. Thayumanavan, Adv. Drug Delivery Rev. 2012, 64, 836. PMC3359494 22342438
  80. [81]G. L. Li, H. Mohwald, D. G. Shchukin, Chem. Soc. Rev. 2013, 42, 3628. 23412474
  81. [82]A. D. Schlüter, A. Halperin, M. Kröger, D. Vlassopoulos, G. Wegner, B. Zhang, ACS Macro Lett. 2014, 3, 991. 35610802
  82. [83]T. C. B. McLeish, in Macromolecular Engineering: Precise Synthesis, Materials Properties, Applications, Wiley‐VCH, Weinheim, Germany, 2007, p. 1605.
  83. [84]M. Emmelius, G. Hörpel, H. Ringsdorf, B. Schmidt, in Polymers in Medicine II, Vol. 34 (Eds.: Chiellini E., Giusti P., Migliaresi C., Nicolais L.), Springer, New York, 1986, pp. 313.
  84. [85]S. Zhong, L. Y. Yung, J. Biomed. Mater. Res. Part A 2009, 91, 114. 18767056
  85. [86]H. Zhang, A. Patel, A. K. Gaharwar, S. M. Mihaila, G. Iviglia, S. Mukundan, H. Bae, H. Yang, A. Khademhosseini, Biomacromolecules 2013, 14, 1299. 23394067 PMC3653976
  86. [87]Y. Wu, Z. Zhou, Q. Fan, L. Chen, M. Zhu, J. Mater. Chem. 2009, 19, 7340.
  87. [88]N. Bait, B. Grassl, C. Derail, A. Benaboura, Soft Matter 2011, 7, 2025.
  88. [89]C. Thevenot, A. Khoukh, S. Reynaud, J. Desbrieres, B. Grassl, Soft Matter 2007, 3, 437. 32900063

Cited by

Sorted by citations

Authors
Thoniyot, P., Tan, M. J., Karim, A. A., Young, D. J., & Loh, X. J.
Affiliations
  • Institute of Materials Research and Engineering (SG)
  • Monash University Malaysia (MY)
  • National University of Singapore (SG)
Corresponding author
Loh, Xian Jun
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2015-01-21
Volume
2
Issue
1-2
Pages
1400010-1400010
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.201400010
PMC
PMC5115280
OpenAlex
W1981512405
Cited by
928
References
1
Citations by year
2026: 56 · 2025: 91 · 2024: 91 · 2023: 99 · 2022: 101 · 2021: 94 · 2020: 100 · 2019: 106 · 2018: 74 · 2017: 60 · 2016: 40 · 2015: 16
FWCI
26.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion, cc-by)
  • Greater South Information System
Funders
Agency for Science, Technology and Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Nanocomposite Synthesis and Irradiation
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Nanocomposites and Properties
Keywords
polymer hydrogels, nanoparticles, metal nanoparticles, metal oxide nanoparticles, composite synthesis, mechanical reinforcement, nanoparticle aggregation, catalysis, electronics, biosensing, drug delivery, nanomedicine, environmental remediation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review