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Cited by 109Aerogels and thermal insulationHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications

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Karamikamkar, Solmaz, Yalcintas, Ezgi Pinar, Haghniaz, Reihaneh, de Barros, Natan Roberto, Mecwan, Marvin, Nasiri, Rohollah, Davoodi, Elham, Nasrollahi, Fatemeh +10 more·2023·Advanced Science
DOI 10.1002/advs.202204681PMC PMC10427407
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Abstract

Aerogel‐based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption, oxygen permeability, and metabolite exchange can be altered. Based on the diverse potential of aerogels in biomedical applications, this paper provides a comprehensive review of fabrication processes including sol‐gel, aging, drying, and self‐assembly along with the materials that can be used to form aerogels. In addition to the technology utilizing aerogel itself, it also provides insight into the applicability of aerogel based on additive manufacturing technology. To this end, how microfluidic‐based technologies and 3D printing can be combined with aerogel‐based materials for biomedical applications is discussed. Furthermore, previously reported examples of aerogels for regenerative medicine and biomedical applications are thoroughly reviewed. A wide range of applications with aerogels including wound healing, drug delivery, tissue engineering, and diagnostics are demonstrated. Finally, the prospects for aerogel‐based biomedical applications are presented. The understanding of the fabrication, modification, and applicability of aerogels through this study is expected to shed light on the biomedical utilization of aerogels.

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  • Interconnected pores and high porosity of aerogel scaffolds provide an ideal environment for cell adhesion and proliferation and facilitate nutrient exchange.

    “The interconnected pores and high porosity of aerogel scaffolds provide an ideal environment for cell adhesion and proliferation, and this structure facilitates the exchange of nutrients [127, 128].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [127]

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Authors
Karamikamkar, S., Yalcintas, E. P., Haghniaz, R., de Barros, N. R., Mecwan, M., Nasiri, R., Davoodi, E., Nasrollahi, F., Erdem, A., Kang, H., Lee, J., Zhu, Y., Ahadian, S., Jucaud, V., Maleki, H., Dokmeci, M. R., Kim, H., & Khademhosseini, A.
Affiliations
  • Terasaki Foundation (US)
  • Terasaki Institute for Biomedical Innovation (TIBI) Los Angeles CA 90024 USA
  • University of Waterloo (CA)
  • University of California, Los Angeles (US)
  • Kocaeli Üniversitesi (TR)
  • Korea University (KR)
  • Pohang University of Science and Technology (KR)
  • University of Cologne (DE)
Corresponding author
  • Karamikamkar, Solmaz
  • Kim, Han‐Jun
  • Khademhosseini, Ali
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2023-05-22
Volume
10
Issue
23
Pages
e2204681-e2204681
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.202204681
PMC
PMC10427407
OpenAlex
W4377564702
Cited by
109
References
330
Citations by year
2026: 25 · 2025: 39 · 2024: 37 · 2023: 8
FWCI
3.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (HL140951, HL137193, CA257558, DK130566)
  • Natural Sciences and Engineering Research Council of Canada (557699 – 2021, 467116484)
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Aerogels and thermal insulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
aerogels, biomaterials, aerogel fabrication, sol-gel synthesis, drying, self-assembly, porous media, pore size, additive manufacturing, microfluidics, 3D printing, regenerative medicine, wound healing, drug delivery, tissue engineering, diagnostics
MeSH terms
Biocompatible Materials, Desiccation, Wound Healing, Tissue Engineering

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