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Cited by 70Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

A self-assembly pro-coagulant powder capable of rapid gelling transformation and wet adhesion for the efficient control of non-compressible hemorrhage

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Lei, Xiong‐Xin, Zou, Chen‐Yu, Hu, Juan‐Juan, Fan, Ming‐Hui, Jiang, Yan‐Lin, Xiong, Ming, Han, Chen, Zhang, Xiu‐Zhen +5 more·2024·Advanced Science
DOI 10.1002/advs.202306289PMC PMC10811489
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Abstract

Rapid and effective control of non‐compressible massive hemorrhage poses a great challenge in first‐aid and clinical settings. Herein, a biopolymer‐based powder is developed for the control of non‐compressible hemorrhage. The powder is designed to facilitate rapid hemostasis by its excellent hydrophilicity, great specific surface area, and adaptability to the shape of wound, enabling it to rapidly absorb fluid from the wound. Specifically, the powder can undergo sequential cross‐linking based on “click” chemistry and Schiff base reaction upon contact with the blood, leading to rapid self‐gelling. It also exhibits robust tissue adhesion through covalent/non‐covalent interactions with the tissues (adhesive strength: 89.57 ± 6.62 KPa, which is 3.75 times that of fibrin glue). Collectively, this material leverages the fortes of powder and hydrogel. Experiments with animal models for severe bleeding have shown that it can reduce the blood loss by 48.9%. Studies on the hemostatic mechanism also revealed that, apart from its physical sealing effect, the powder can enhance blood cell adhesion, capture fibrinogen, and synergistically induce the formation of fibrin networks. Taken together, this hemostatic powder has the advantages for convenient preparation, sprayable use, and reliable hemostatic effect, conferring it with a great potential for the control of non‐compressible hemorrhage.

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  • Employing materials capable of absorbing blood and adhering to tissues is a promising therapeutic approach to treating uncontrolled bleeding.

    “Employing materials capable of absorbing blood (or eliminating bodily fluids) and adhering to tissues is a promising therapeutic approach to treating uncontrolled bleeding [127].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [127]

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Cited by

Sorted by citations

Authors
Lei, X., Zou, C., Hu, J., Fan, M., Jiang, Y., Xiong, M., Han, C., Zhang, X., Li, Y., Zhao, L., Nie, R., Li‐Ling, J., & Xie, H.
Affiliations
  • Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan 610041 P. R. China
  • Sichuan University (CN)
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2023-12-03
Volume
11
Issue
4
Pages
e2306289-e2306289
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.202306289
PMC
PMC10811489
OpenAlex
W4389291390
Cited by
70
References
0
Citations by year
2026: 25 · 2025: 31 · 2024: 13 · 2023: 1
FWCI
14.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
West China Hospital, Sichuan University (ZYJC18002)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
non-compressible hemorrhage, hemostatic powder, biopolymers, click chemistry, Schiff base reaction, tissue adhesion, fibrin network formation, blood loss reduction
MeSH terms
Tissue Adhesions, Animals, Coagulants, Hemorrhage, Hemostatics, Powders

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