Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Open accessAbstract
The impressive adhesive capacity of marine mussels has inspired various fascinating designs in biomedical fields. Mussel-inspired injectable adhesive hydrogels, as a type of promising mussel-inspired material, have attracted much attention due to their minimally invasive property and desirable functions provided by mussel-inspired components. In recent decades, various mussel-inspired injectable adhesive hydrogels have been designed and widely applied in numerous biomedical fields. The rational incorporation of mussel-inspired catechol groups endows the injectable hydrogels with the potential to exhibit many properties, including tissue adhesiveness and self-healing, antimicrobial, and antioxidant capabilities, broadening the applications of injectable hydrogels in biomedical fields. In this review, we first give a brief introduction to the adhesion mechanism of mussels and the characteristics of injectable hydrogels. Further, the typical design strategies of mussel-inspired injectable adhesive hydrogels are summarized. The methodologies for integrating catechol groups into polymers and the crosslinking methods of mussel-inspired hydrogels are discussed in this section. In addition, we systematically overview recent mussel-inspired injectable adhesive hydrogels for biomedical applications, with a focus on how the unique properties of these hydrogels benefit their applications in these fields. The challenges and perspectives of mussel-inspired injectable hydrogels are discussed in the last section. This review may provide new inspiration for the design of novel bioinspired injectable hydrogels and facilitate their application in various biomedical fields.
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TL;DR
This review summarizes design strategies for mussel-inspired injectable adhesive hydrogels, focusing on catechol incorporation, crosslinking chemistry, and biomedical applications. It highlights catechol-enabled tissue adhesiveness, self-healing, antimicrobial, antioxidant, and photothermal properties, while noting challenges such as catechol oxidation and storage instability.
Key findings
- Mussel adhesion relies on DOPA/catechol; DOPA content in Mfps 3 and Mfps 5 reaches 20% and 28%, respectively. Catechol forms hydrogen bonding, coordination, π–π, and π–cation interactions, and after oxidation to quinone can form covalent Schiff base or Michael addition bonds.
- Design strategies include incorporating catechol groups via classic organic reactions, polymerization of catechol-based monomers, or biosynthesis; crosslinking can be catechol-mediated (metal coordination, oxidation-induced coupling, boronate–catechol complexation) or via regular covalent/noncovalent methods, often combined.
- Applications span wound closure/healing, hemostasis, bone and cartilage repair, drug delivery, smart sensors, and biological coatings. Reported examples include iCMBA adhesive strength ~123 kPa (about eight times commercial fibrin glue), PPD hydrogel ~147 kPa, CCS@gel ~44.9 kPa, CMC-based hydrogel ~9.7 kPa, curcumin release over 4 weeks, DMOG release over 7 days, Bi2Se3-DOX@PDA retention at injection site for at least 12 days, and a strain sensor detecting 200 mg with 33 ms response time.
- Challenges include catechol oxidation reducing adhesion and causing accidental crosslinking, difficult long-term storage of precursor solutions, catechol’s polymerization-inhibiting activity, and the need to balance catechol content between interfacial adhesion and crosslinking.
Methods
- Narrative review of mussel-inspired injectable adhesive hydrogels, synthesizing literature on adhesion mechanisms, catechol incorporation, crosslinking strategies, and biomedical applications.
- No primary experimental data or samples; the paper describes and categorizes examples from cited studies, with summary tables (e.g., Table 2, Table 3, Table 5).
- Main analysis is thematic: design strategies, crosslinking approaches, application-specific benefits, and stated challenges/perspectives.
Limitations
- The paper states challenges: catechol oxidation can reduce adhesive performance and induce accidental crosslinking; long-term storage of precursor solutions is usually difficult; catechol acts as a polymerization inhibitor; and balancing catechol groups for adhesion versus crosslinking is important.
- The paper also notes that direct polymerization of catechol-based monomers is usually difficult and that the detailed mechanism of unprotected polymerization remains elusive.
- Evident from the text: as a narrative review, it does not report a systematic search strategy, inclusion criteria, or quantitative meta-analysis, so coverage and conclusions rely on selected examples.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
54 of 184 cited sources checked · 36 supported · 0 flagged · accuracy not yet measured
- Premisecitation
Marine mussels secrete proteinaceous glues to tightly adhere to wet rock surfaces.
“In nature, marine mussels secrete proteinaceous glues to tightly adhere to wet rock surfaces [1].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [1] Lee, 2007, Mussel-inspired surface chemistry for multifunctional coatings, Science source
- Premisecitation
If catechol groups are oxidized by oxidizing agents such as sodium periodate (NaIO4), the catechol group transfers to a quinone structure.
“If the catechol groups are oxidized by oxidizing agents, such as sodium periodate (NaIO4), the catechol group will transfer to a quinone structure [12].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [12] Hofman, 2018, Bioinspired underwater adhesives by using the supramolecular toolbox, Adv. Mater. source
- Premisecitation
Mussel-inspired injectable hydrogels simultaneously possess the minimally invasive property of injectable hydrogels and desirable functions provided by mussel-inspired components, which may include tissue adhesiveness and self-healing, antimicrobial, and antioxidant capabilities.
“This type of hydrogel simultaneously possesses the minimally invasive property of injectable hydrogels and the desirable functions provided by mussel-inspired components, which may include tissue adhesiveness and self-healing, antimicrobial, and antioxidant capabilities [33].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [33] Rahimnejad, 2017, Mussel-inspired hydrogel tissue adhesives for wound closure, RSC Adv. source
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
- Premisecitation
In the proteins on the surface of mussel adhesive plaques (Mfps 3 and Mfps 5), the DOPA contents reach 20% and 28%, respectively.
“In the proteins on the surface of mussel adhesive plaques (Mfps 3 and Mfps 5), the contents of DOPA are higher and reach 20% and 28%, respectively [8].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [8] Lee, 2011, Mussel-inspired adhesives and coatings, Annu. Rev. Mater. Res. source
- Premisecitation
3,4-Dihydroxyphenylalanine (DOPA) exists in mussel adhesive proteins.
“These works reveal that a noncanonical amino acid, namely, 3,4-dihydroxyphenylalanine (DOPA) exists in the mussel adhesive proteins [6,7].”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [6] Lee, 2007, A reversible wet/dry adhesive inspired by mussels and geckos, Nature source
- cites [7] Liu, J., Song, J., Zeng, L., and Hu, B. (2024). An overview on the adhesion mechanisms of typical aquatic organisms and the applications of biomimetic adhesives in aquatic environments. Int. J. Mol. Sci., 25. source
- Premisecitation
The catechol group can form multiple covalent and noncovalent interactions with specific surfaces.
“The main functional group in DOPA is the catechol group, which can form multiple covalent and noncovalent interactions with specific surfaces [9,10,11] (Figure 1).”
Quote in the paperSubstantial claim1 of 3 sources checked- cites [9] Cui, 2021, Recent advances in wet adhesives: Adhesion mechanism, design principle and applications, Prog. Polym. Sci. source
- cites [10] Ye, 2011, Bioinspired catecholic chemistry for surface modification, Chem. Soc. Rev. source
- cites [11] Guo, 2020, Recent progress in synthesis and application of mussel-inspired adhesives, Nanoscale source
- Rests on an assumption: The main functional group in DOPA is the catechol group.
- Premisecitation
The fascinating properties of mussel-inspired injectable hydrogels benefit their application in numerous biomedical fields, such as wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.
“Their fascinating properties benefit their application in numerous biomedical fields, such as wound closure and healing [36,37], hemostasis [38,39], bone repair [40,41], drug delivery [42,43], smart sensors [44], biological coatings [45], etc. (Figure 2).”
Quote in the paperNot a substantial claim2 of 6 sources checked- cites [36] Yang, 2022, Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing, Bioact. Mater. source
- cites [37] Liang, 2022, Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing, Nano-Micro Lett. source
- cites [38] Zhang, 2023, An injectable, robust double network adhesive hydrogel for efficient, real-time hemostatic sealing, Chem. Eng. J. source
- cites [39] Song, 2019, Dopa-empowered schiff base forming alginate hydrogel glue for rapid hemostatic control, Macromol. Res. source
- cites [40] Wu, 2023, Engineering mussel-inspired multifunctional nanocomposite hydrogels to orchestrate osteoimmune microenvironment and promote bone healing, Mater. Des. source
- cites [41] Wang, 2021, Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration, ACS Appl. Mater. Interfaces source
- Premisecitation
The mono-complex dominates when the pH is lower than 5.6.
“The mono-complex dominates when the pH is lower than 5.6.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [62] Harrington, 2011, Ph-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli, Proc. Natl. Acad. Sci. USA source
- Premisecitation
Tri-complexes dominate only when the pH is larger than 9.1.
“Tri-complexes dominate only when the pH is larger than 9.1 [62].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [62] Harrington, 2011, Ph-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli, Proc. Natl. Acad. Sci. USA source
- Premisecitation
The catechol group in polymers can coordinate with metal ions, such as Fe3+, Al3+, Zn2+, Cu2+, and Ti3+, to form coordination crosslinking.
“The catechol group in polymers can coordinate with metal ions, such as Fe3+, Al3+, Zn2+, Cu2+, and Ti3+, to form coordination crosslinking [12].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [12] Hofman, 2018, Bioinspired underwater adhesives by using the supramolecular toolbox, Adv. Mater. source
Section 7.1 (page unavailable) describes coordination crosslinking of catechol-functionalized PEG with Fe3+ and discusses Al3+; it also describes catechol chelation with Zn2+. Section 3.1.2 (page unavailable) names Ti4+, not the claimed Ti3+. The passages mentioning Cu2+ do not establish that it crosslinks catechol groups. (LLM, conf=0.88)
Experimental — accuracy not yet measured
- Premisecitation
Using classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin, and synthetic polymers, such as PEG-based polymers.
“Using these classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin (GT), and synthetic polymers, such as polyethylene glycol (PEG)-based polymers [45,47,51,52,53,54,55].”
Quote in the paperNot a substantial claim1 of 7 sources checked- cites [45] Hu, 2018, Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair, Biomater. Sci. source
- cites [47] Faure, 2013, Catechols as versatile platforms in polymer chemistry, Prog. Polym. Sci. source
Section 3.3.3 describes catechol grafting onto hyaluronic acid, poly(L-lysine), and chitosan; section 3.3.4 describes modification of gelatin and PEG-based polymers. I found no passage supporting the listed SA example (searched for alginate), so the full list is not supported by this source. (LLM, conf=0.83)
Experimental — accuracy not yet measured - cites [51] Zhang, 2021, An in situ catechol functionalized ε-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis, Inter. J. Biol. Macromol. source
- cites [52] Guo, 2019, A facile strategy for preparing tough, self-healing double-network hyaluronic acid hydrogels inspired by mussel cuticles, Macromol. Mater. Eng. source
- cites [53] Hou, M.D., Wang, X.C., Yue, O.Y., Zheng, M.H., Zhang, H.J., and Liu, X.H. (2022). Development of a multifunctional injectable temperature-sensitive gelatin-based adhesive double-network hydrogel. Biomater. Adv., 134. source
- cites [54] Ryu, 2015, Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review, Acta Biomater. source
- cites [55] Zhong, 2021, Mussel-inspired hydrogels as tissue adhesives for hemostasis with fast-forming and self-healing properties, Eur. Polym. J. source
- Premisecitation
The coordination of catechol and Fe3+ is strongly influenced by pH.
“It has been reported that the coordination of catechol and Fe3+ is strongly influenced by pH [37,61].”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [37] Liang, 2022, Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing, Nano-Micro Lett. source
- cites [61] Li, 2020, Bioinspired double-dynamic-bond crosslinked bioadhesive enables post-wound closure care, Adv. Funct. Mater. source
- Premisecitation
When the ratio of catechol to Fe3+ is high (the amount of Fe3+ is low), catechol and Fe3+ are prone to forming more tri-complexes.
“When the ratio of catechol to Fe3+ is high (the amount of Fe3+ is low), catechol and Fe3+ are prone to forming more tri-complexes [63,64].”
Quote in the paperNot a substantial claim1 of 2 sources checked - Premisecitation
When the pH is in the range of 5.6-9.1, the bis-complex accounts for a large proportion.
“When the pH is in the range of 5.6–9.1, the bis-complex accounts for a large proportion.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [62] Harrington, 2011, Ph-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli, Proc. Natl. Acad. Sci. USA source
- Premisecitation
Many methods have been developed to incorporate the catechol group into polymers, including incorporation by classic organic reactions, polymerization of catechol-based monomers, and biosynthesis of catechol-containing proteins.
“During recent decades, many methods have been developed to incorporate the catechol group into polymers [4,47], including the incorporation of the catechol group by classic organic reactions, polymerization of catechol-based monomers, and biosynthesis of catechol-containing proteins (Figure 3).”
Quote in the paperNot a substantial claim2 of 2 sources checked- cites [4] Forooshani, 2017, Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein, J. Polym. Sci. A Polym. Chem. source
- cites [47] Faure, 2013, Catechols as versatile platforms in polymer chemistry, Prog. Polym. Sci. source
Sections 3.3 and 3.1 describe chemical incorporation of catechols into preformed polymers and polymerization of catechol-bearing monomers. The Introduction describes naturally occurring DOPA-containing mussel proteins, but the passages do not describe biosynthesis of catechol-containing proteins as a developed method for incorporating catechols into polymers. (LLM, conf=0.84)
Experimental — accuracy not yet measured
- Premisecitation
Unprotected polymerizations of catechol-based monomers have been reported in recent years.
“Even so, unprotected polymerizations of catechol-based monomers have been reported in recent years [56,57].”
Quote in the paperNot a substantial claim1 of 2 sources checked - Premisecitation
In clinical practice, suturing is still the dominant way to close open wounds.
“In clinical practice, suturing is still the dominant way to close open wounds [13,92].”
Quote in the paperNot a substantial claim1 of 2 sources checked - Premisecitation
Nanomaterials, with their large surface area, generate nanoscale effects that significantly enhance blood absorption and cell adhesion.
“Nanomaterials, with their large surface area, are capable of generating nanoscale effects that significantly enhance blood absorption and cell adhesion [119].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [119] Cui, G.H., Guo, X.Y., Su, P., Zhang, T.S., Guan, J., and Wang, C.A. (2023). Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing. Front. Chem., 11. source
- Premisecitation
Recent studies show that the synergistic effect of cation and catechol promoted wet adhesion.
“Recent studies show that the synergistic effect of cation and catechol promoted wet adhesion [102,103].”
Quote in the paperSubstantial claim1 of 2 sources checked - Premisecitation
Employing materials capable of absorbing blood and adhering to tissues is a promising therapeutic approach to treating uncontrolled bleeding.
“Employing materials capable of absorbing blood (or eliminating bodily fluids) and adhering to tissues is a promising therapeutic approach to treating uncontrolled bleeding [127].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [127] Lei, 2024, A self-assembly pro-coagulant powder capable of rapid gelling transformation and wet adhesion for the efficient control of non-compressible hemorrhage, Adv. Sci. source
- Premisecitation
After injection at bleeding sites, PDPC hydrogels rapidly absorb blood and adhere tightly to the wound, forming an effective hemostatic barrier.
“After injection at bleeding sites, the PDPC hydrogels can rapidly absorb blood and adhere tightly to the wound, forming an effective hemostatic barrier.”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [122] Hu, 2023, An all-in-one “4a hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing, Small source
Section 2.5 (page not provided) says the PDPC hydrogel can absorb blood and that applying it to a bleeding site forms a tight barrier that rapidly seals the wound; animal tests also show rapid adhesion and hemostasis. Section 2.1 establishes that the hydrogel is injectable, but the hemostasis experiments describe applying it to wounds, not injecting it at the bleeding sites. (LLM, conf=0.84)
Experimental — accuracy not yet measured
- Premisecitation
Integration of bioactive growth factors within scaffolds promotes bone repair and regeneration.
“In bone tissue engineering, the integration of bioactive growth factors within scaffolds has emerged as an innovative approach to promote bone repair and regeneration [133].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [133] Bai, 2018, Bioactive hydrogels for bone regeneration, Bioact. Mater. source
- Premisecitation
Traditional oral or intravenous administration routes may restrict drug efficacy.
“Traditional administration routes, such as oral or intravenous delivery, may sometimes restrict the efficacy of drugs [141].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [141] Bernhard, 2021, Supramolecular engineering of hydrogels for drug delivery, Adv. Drug Del. Rev. source
- Premisecitation
The thiol group can restore dopa from oxidized dopaquinone, benefiting preservation of catechol groups.
“The thiol group has been reported to be able to restore dopa from oxidized dopaquinone [155].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [155] Yu, 2011, Mussel protein adhesion depends on interprotein thiol-mediated redox modulation, Nat. Chem. Biol. source
- Premisereasoning
Long-term storage of precursor solutions of mussel-inspired hydrogels is usually difficult.
“The long-term storage of precursor solutions of mussel-inspired hydrogels is usually difficult.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [155] Yu, 2011, Mussel protein adhesion depends on interprotein thiol-mediated redox modulation, Nat. Chem. Biol. source
The Abstract says dopa readily oxidizes and that this presents challenges for its use in synthetic polymers with dopa-like side chains. It does not address mussel-inspired hydrogel precursor solutions or say that their long-term storage is usually difficult; searches for storage and hydrogel precursors found no such passage. (LLM, conf=0.76)
Experimental — accuracy not yet measured
- Interpretationreasoning
DOPA plays an essential role in the adhesion of mussels.
“This phenomenon indicates that DOPA plays an essential role in the adhesion of mussels.”
Quote in the paperSubstantial claim - Premisecitation
In situ injectable hydrogels utilize the sol-gel transition process to achieve a minimally invasive way of application.
“Different from preformed hydrogels, in situ injectable hydrogels utilize the sol–gel transition process to achieve a minimally invasive way of application [30].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [30] Yu, 2008, Injectable hydrogels as unique biomedical materials, Chem. Soc. Rev. source
- Premisecitation
Under oxidation, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition.
“Under this circumstance, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition [13].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [13] Nam, 2021, Polymeric tissue adhesives, Chem. Rev. source
- Premisereasoning
For internal applications, a relatively large incision is usually required to implant a preformed hydrogel into the body.
“In addition, for internal applications, a relatively large incision is usually required to implant the preformed hydrogel into the body.”
Quote in the paperSubstantial claim - Premisecitation
Preformed hydrogels usually exhibit high physical performance, such as high mechanical properties and strong adhesive properties.
“Therefore, preformed hydrogels usually exhibit high physical performance, such as high mechanical properties, strong adhesive properties, etc.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [28] Jiang, 2024, Effect of hydroxy group activity on the hydrogel formation temperature of β-cyclodextrins and its application in profile control, J. Ind. Eng. Chem. source
- Interpretationcitation
The minimally invasive delivery method enables injectable hydrogels to be a promising tool in clinical practice.
“Nevertheless, the minimally invasive delivery method enables injectable hydrogels to be a promising tool in clinical practice [32].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [32] Li, 2021, Advances in biodegradable and injectable hydrogels for biomedical applications, J. Control. Release source
- Premisecitation
Preformed hydrogels find it difficult to precisely fill irregular defects.
“However, since preformed hydrogels are formed in molds, they find it difficult to precisely fill irregular defects [29].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [29] Gao, 2020, In situ formation of injectable hydrogels for chronic wound healing, J. Mater. Chem. B source
- Interpretationreasoning
It is difficult to directly use natural mussel adhesive proteins to develop injectable adhesive hydrogels.
“Therefore, it is difficult to directly use natural mussel adhesive proteins to develop injectable adhesive hydrogels.”
Quote in the paperSubstantial claim - Premisereasoning
Injectable hydrogels can fill irregular shapes well.
“Therefore, the injectable hydrogels can fill irregular shapes well.”
Quote in the paperSubstantial claim - Premisecitation
The yield of extraction of mussel adhesive proteins is extremely low.
“The yield of extraction of mussel adhesive proteins is extremely low [46].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [46] Hwang, 2007, Practical recombinant hybrid mussel bioadhesive fp-151, Biomaterials source
- Premisecitation
Due to limited formation conditions, such as 37 °C and physiological pH, injectable hydrogels usually exhibit weak mechanical and adhesive properties compared with preformed hydrogels.
“However, due to limited formation conditions, such as 37 °C and physiological pH, injectable hydrogels usually exhibit weak mechanical and adhesive properties compared with preformed hydrogels [31].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [31] Sun, 2020, Recent advances of injectable hydrogels for drug delivery and tissue engineering applications, Polym. Test. source
- Premisenone given
Three types of catechol-Fe complexes exist: mono-, bis-, and tri-catechol-Fe complexes.
“Three types of catechol–Fe complexes exist, which are mono-, bis-, and tri-catechol–Fe complexes.”
Quote in the paperNot a substantial claim - Premisecitation
Kim and coworkers found that PGADA was able to gel in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2).
“For example, Kim and coworkers synthesized catechol-modified poly (γ-glutamic acid) (PGADA). They found that PGADA was able to gel in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2) [68].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [68] Kim, 2020, Enzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property, ACS Biomater. Sci. Eng. source
- Premisenone given
Among these metal ions, Fe3+ is widely studied and used in the preparation of mussel-inspired injectable adhesive hydrogels.
“Among these metal ions, Fe3+ is widely studied and used in the preparation of mussel-inspired injectable adhesive hydrogels.”
Quote in the paperNot a substantial claim - Premisereasoning
Incorporation of the catechol groups into the polymers is usually the first step to developing mussel-inspired injectable hydrogels.
“Incorporation of the catechol groups into the polymers is usually the first step to developing mussel-inspired injectable hydrogels.”
Quote in the paperNot a substantial claim - Premisecitation
In an alkaline environment, catechol groups are prone to oxidation to form catechol-catechol dimers.
“In an alkaline environment, catechol groups are prone to oxidation to form catechol–catechol dimers [13].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [13] Nam, 2021, Polymeric tissue adhesives, Chem. Rev. source
- Premisereasoning
Another reaction capable of incorporating the catechol group into a polymer chain is the Schiff base reaction.
“Another reaction capable of the incorporation of the catechol group into a polymer chain is the Schiff base reaction.”
Quote in the paperNot a substantial claim - Premisecitation
The rational regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, is important for successful polymerization.
“The rational regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [57] White, 2013, Switching the adhesive state of catecholic hydrogels using phototitration, Macromolecules source
- Premisecitation
The incorporation of specific enzymes contributes to the gelation of catechol-containing polymers by enzymatically crosslinking.
“The incorporation of specific enzymes also contributes to the gelation of catechol-containing polymers by enzymatically crosslinking.”
Quote in the paperNot a substantial claim - Premisereasoning
Using metal ions with specific functions to crosslink catechol-containing polymers is effective in developing multifunctional injectable hydrogels.
“In addition, using metal ions with specific functions to crosslink the catechol-containing polymers is found to be effective in developing multifunctional injectable hydrogels.”
Quote in the paperSubstantial claim - Premisecitation
The molar ratio of catechol to Fe3+ influences the coordination types of catechol and Fe3+.
“In addition, the molar ratio of catechol to Fe3+ influences the coordination types of catechol and Fe3+.”
Quote in the paperNot a substantial claim - Premisecitation
The tri-complex is the most stable form of catechol-Fe complexes.
“The tri-complex is the most stable form [60].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [60] Lee, 2016, Phase controllable hyaluronic acid hydrogel with iron(iii) ion catechol induced dual cross-linking by utilizing the gap of gelation kinetics, Macromolecules source
- Premisereasoning
Mussel-inspired injectable adhesive hydrogels are usually developed by engineering the catechol group into the gel network.
“Due to the essential role of DOPA in mussel adhesion, mussel-inspired injectable adhesive hydrogels are usually developed by engineering the catechol group into the gel network.”
Quote in the paperNot a substantial claim - Premisereasoning
Adding oxidizing agents can promote the oxidation of the catechol groups, thus benefiting the gelation process of catechol-containing polymers.
“Adding oxidizing agents can promote the oxidation of the catechol groups, thus benefiting the gelation process of catechol-containing polymers.”
Quote in the paperSubstantial claim - Premisereasoning
Compared with regular injectable hydrogels, mussel-inspired injectable adhesive hydrogels usually show higher adhesive properties due to the existence of the catechol groups.
“Compared with regular injectable hydrogels, mussel-inspired injectable adhesive hydrogels usually show higher adhesive properties due to the existence of the catechol groups.”
Quote in the paperSubstantial claim - Premisecitation
Tissue adhesives are capable of closing an open wound by bonding the edges of wound tissues.
“Tissue adhesives are capable of closing an open wound by bonding the edges of wound tissues [96].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [96] Sun, 2020, An injectable and instant self-healing medical adhesive for wound sealing, ACS Appl. Mater. Interfaces source
- Premisecitation
Noncovalent interactions are frequently introduced in the design of mussel-inspired adhesive hydrogels.
“Noncovalent interactions are frequently introduced in the design of mussel-inspired adhesive hydrogels.”
Quote in the paperNot a substantial claim - Premisereasoning
Due to the ability to adapt to the shapes of wounds, injectable hydrogels have the potential to be used as tissue adhesives.
“Due to the ability to adapt to the shapes of wounds, injectable hydrogels have the potential to be used as tissue adhesives.”
Quote in the paperSubstantial claim - Premisereasoning
Mussel-inspired adhesive hydrogels still show advantages over other types of adhesive hydrogels.
“Nevertheless, mussel-inspired adhesive hydrogels still show their advantages.”
Quote in the paperSubstantial claim - Interpretationreasoning
Noncovalent interactions usually work with covalent crosslinking.
“Therefore, noncovalent interactions usually work with covalent crosslinking.”
Quote in the paperNot a substantial claim - Premisereasoning
With multiple desirable properties, mussel-inspired injectable adhesive hydrogels have been widely applied in numerous biomedical fields.
“With multiple desirable properties, mussel-inspired injectable adhesive hydrogels have been widely applied in numerous biomedical fields.”
Quote in the paperSubstantial claim - Premisereasoning
Mussel-inspired injectable hydrogels can also be crosslinked by other regular covalent or noncovalent interactions.
“Mussel-inspired injectable hydrogels can also be crosslinked by other regular covalent or noncovalent interactions (Figure 6).”
Quote in the paperNot a substantial claim - Premisecitation
Interactions including hydrogen bonding, π-π stacking, cation-π interactions, electrostatic forces, and hydrophobic effects are frequently employed to create self-healable hydrogel networks.
“Interactions, including hydrogen bonding, π-π stacking, cation-π interactions, electrostatic forces, and hydrophobic effects, are frequently employed to create self-healable hydrogel networks [3,51].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [3] Zhang, 2020, Mussel-inspired hydrogels: From design principles to promising applications, Chem. Soc. Rev. source
- cites [51] Zhang, 2021, An in situ catechol functionalized ε-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis, Inter. J. Biol. Macromol. source
- Premisenone given
The boron ester bond is predominantly formed through the complexation of borate with the catechol group, enabling a versatile and robust network formation.
“The boron ester bond is predominantly formed through the complexation of borate with the catechol group, enabling a versatile and robust network formation.”
Quote in the paperNot a substantial claim - Premisecitation
Compared with covalent bonds, noncovalent interactions are usually weak.
“Compared with covalent bonds, noncovalent interactions are usually weak [71].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [71] Hobza, 2000, Noncovalent interactions: A challenge for experiment and theory, Chem. Rev. source
- Premisereasoning
The superior adhesive performance of mussel-inspired injectable adhesive hydrogels has been confirmed by various methods, including the lap shear test, tensile test, 180° peel test, 90° peel test, wound closure test, and burst pressure test.
“Their superior adhesive performance has been confirmed by various methods, including the lap shear test, tensile test, 180° peel test, 90° peel test, wound closure test, and burst pressure test (Figure 8).”
Quote in the paperSubstantial claim - Premisereasoning
Multiple crosslinked structures can endow the hydrogel with enhanced properties.
“The multiple crosslinked structures can endow the hydrogel with enhanced properties.”
Quote in the paperSubstantial claim - Premisecitation
Dynamic boron ester-based crosslinking is used in the preparation of mussel-inspired injectable hydrogels.
“In addition to catechol–metal coordination crosslinking and oxidation-induced catechol-based crosslinking, dynamic boron ester-based crosslinking is used in the preparation of mussel-inspired injectable hydrogels.”
Quote in the paperNot a substantial claim - Premisereasoning
Mussel-inspired injectable adhesive hydrogels have been widely used as tissue adhesives for wound treatments.
“Therefore, mussel-inspired injectable adhesive hydrogels have been widely used as tissue adhesives for wound treatments.”
Quote in the paperSubstantial claim - Premisecitation
Mussel-inspired injectable adhesive hydrogels are also able to be prepared by the combination of catechol-mediated and other regular crosslinking methods.
“Mussel-inspired injectable adhesive hydrogels are also able to be prepared by the combination of catechol-mediated and other regular crosslinking methods [61].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [61] Li, 2020, Bioinspired double-dynamic-bond crosslinked bioadhesive enables post-wound closure care, Adv. Funct. Mater. source
- Premisecitation
Many mussel-inspired injectable hydrogels have been developed for hemorrhage control.
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
Quote in the paperNot a substantial claim0 of 2 sources checked - Premisecitation
CCS@gel exhibited an adhesive strength of about 44.9 kPa due to catechol and remnant aldehyde groups.
“Due to the catechol and remnant aldehyde groups, CCS@gel exhibited a remarkable adhesive strength of about 44.9 kPa.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [75] Fang, 2021, A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair, Carbohydr. Polym. source
- Premisecitation
Injectable hydrogel-based tissue adhesives, with shape adaptability and minimally invasive characteristics, have become promising alternatives for hemorrhage control.
“Injectable hydrogel-based tissue adhesives, with their shape adaptability and minimally invasive characteristics, have become promising alternatives for hemorrhage control [116].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [116] Wei, 2023, Superwetting injectable hydrogel with ultrastrong and fast tissue adhesion for minimally invasive hemostasis, Adv. Healthcare Mater. source
- Premisereasoning
Since polyphenolic compounds are ROS scavengers, mussel-inspired adhesive hydrogels have the potential to treat diabetic wounds.
“Since polyphenolic compounds are ROS scavengers, mussel-inspired adhesive hydrogels have the potential to treat diabetic wounds.”
Quote in the paperSubstantial claim - Premisecitation
Catechol is remarkably effective for adhesion to wet tissues.
“Recent studies have shed light on the remarkable effectiveness of catechol for adhesion to wet tissues [117,118].”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [117] Cui, 2019, Water-triggered hyperbranched polymer universal adhesives: From strong underwater adhesion to rapid sealing hemostasis, Adv. Mater. source
- cites [118] Lu, 2021, Mussel-inspired blue-light-activated cellulose-based adhesive hydrogel with fast gelation, rapid haemostasis and antibacterial property for wound healing, Chem. Eng. J. source
- Interpretationreasoning
Mussel-inspired injectable hydrogel adhesives offer a promising solution for the healing of infected wounds.
“Therefore, mussel-inspired injectable hydrogel adhesives offer a promising solution for the healing of infected wounds.”
Quote in the paperSubstantial claim - Interpretationreasoning
Mussel-inspired injectable hydrogels are particularly suitable for hemostasis.
“Among them, mussel-inspired injectable hydrogels are particularly suitable for hemostasis due to the following reasons:”
Quote in the paperSubstantial claim- Rests on an assumption: Hemorrhage control is typically achieved through the formation of a barrier that effectively seals the site of bleeding.
- Rests on an assumption: A robust hemostatic barrier requires a hemostatic agent with exceptional adhesive strength in the presence of blood and adequate mechanical strength to firmly seal the wound without breakage.
- Premisecitation
Incorporation of Laponite XLG into a PAA/OCMC/TA mussel-inspired hydrogel benefited its mechanical properties.
“The incorporation of Laponite XLG benefited the mechanical properties of the hydrogel.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [126] Xu, L., Jiao, G.H., Huang, Y.L., Ren, P.F., Liang, M., Wei, D.D., and Zhang, T.Z. (2024). Laponite nanoparticle-crosslinked carboxymethyl cellulose-based injectable hydrogels with efficient underwater-specific adhesion for rapid hemostasis. Inter. J. Biol. Macromol., 255. source
- Premisereasoning
Adjustable physical and chemical properties of nanomaterials facilitate their integration with other hemostatic materials, enhancing hemostatic capabilities.
“Moreover, their adjustable physical and chemical properties further facilitate their integration with other hemostatic materials, thereby enhancing hemostatic capabilities.”
Quote in the paperSubstantial claim - Premisereasoning
Multiple crosslinking ways derived from catechol groups endow hydrogels with the potential to be mechanically strong.
“The multiple crosslinking ways derived from the catechol groups further endow the hydrogels with the potential to be mechanically strong.”
Quote in the paperSubstantial claim - Premisecitation
CMC-based hydrogel was effective as a wound dressing.
“It was effective as a wound dressing.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [90] Zhao, 2021, Chitosan derivative-based mussel-inspired hydrogels as the dressings and drug delivery systems in wound healing, Cellulose source
- Premisecitation
PDAEA-Fe3+ hydrogels demonstrated excellent adhesive properties due to strong binding between dopamine and Fe3+.
“Owing to the strong binding between dopamine and Fe3+, the hydrogels demonstrated excellent adhesive properties.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [42] Gong, 2017, Injectable dopamine-modified poly(α,β-aspartic acid) nanocomposite hydrogel as bioadhesive drug delivery system, J. Biomed. Mater. Res. Part A source
- Premisecitation
GMAD/LP hydrogel can serve as an osteoimmune regulator to promote bone regeneration.
“It can serve as an osteoimmune regulator to promote bone regeneration [40].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [40] Wu, 2023, Engineering mussel-inspired multifunctional nanocomposite hydrogels to orchestrate osteoimmune microenvironment and promote bone healing, Mater. Des. source
- Premisecitation
After loading with PNF, CMC-based hydrogel significantly accelerated wound healing.
“After being loaded with PNF (a drug from Panax Notoginseng), the CMC-based hydrogel significantly accelerated wound healing [90].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [90] Zhao, 2021, Chitosan derivative-based mussel-inspired hydrogels as the dressings and drug delivery systems in wound healing, Cellulose source
- Premisecitation
Injectable hydrogels are promising for drug delivery due to tunable physical and chemical properties, controlled degradation, high water content, and minimally invasive delivery.
“Injectable hydrogels are promising in the fields of drug delivery due to their tunable physical and chemical properties, controlled degradation, high water content, and minimally invasive delivery capabilities.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [145] Umesh, 2023, A self-healable and injectable hydrogel for pH-responsive doxorubicin drug delivery in vitro and in vivo for colon cancer treatment, Mater. Today Chem. source
- cites [146] Qu, 2018, Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized “smart” drug release, Acta Biomater. source
- cites [147] Fathi, 2019, Dual thermo-and ph-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer, Int. J. Biol. Macromol. source
- Premisecitation
AD/CS/RSF hydrogels have exceptional adhesion strength on wet surfaces.
“Zhang and coworkers developed mussel-inspired AD/CS/RSF hydrogels with exceptional adhesion strength on wet surfaces.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [140] Zhang, F.X., Liu, P., Ding, W., Meng, Q.B., Su, D.H., Zhang, Q.C., Lian, R.X., Yu, B.Q., Zhao, M.D., and Dong, J. (2021). Injectable mussel-inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 278. source
- Premisecitation
In a femoral defect model, GO-PHA-CP hydrogels promoted bone regeneration.
“In the femoral defect model, GO-PHA-CP hydrogels showed effectiveness in promoting bone regeneration [89].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [89] Ma, W.C., Yang, M.L., Wu, C., Wang, S.Y., and Du, M. (2023). Bioinspired self-healing injectable nanocomposite hydrogels based on oxidized dextran and gelatin for growth-factor-free bone regeneration. Int. J. Biol. Macromol., 251. source
- Premisecitation
HUVECs treated with DMOG-loaded HA-Cys/PDA hydrogel showed enhanced capillary tube formation.
“In vitro results indicate that human umbilical vein endothelial cells (HUVECs) treated with DMOG-loaded HA-Cys/PDA hydrogel showed an enhanced capillary tube formation, confirming its potential in tissue engineering [149].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [149] Yegappan, 2019, Nano polydopamine crosslinked thiol-functionalized hyaluronic acid hydrogel for angiogenic drug delivery, Colloids Surf. B Biointerfaces source
- Interpretationreasoning
Mussel-inspired adhesive hydrogels with high adhesive properties can remain at a specific site for an extended period.
“Mussel-inspired adhesive hydrogels with high adhesive properties can allow the gels to remain at a specific site for an extended period.”
Quote in the paperSubstantial claim - Premisecitation
In vivo cranial bone regeneration experiments confirmed the efficacy of nHA/PLGA-BP-Dex DC hydrogel in bone repair.
“In vivo cranial bone regeneration experiments confirmed the efficacy of the nHA/PLGA-BP-Dex DC hydrogel in bone repair.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [41] Wang, 2021, Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration, ACS Appl. Mater. Interfaces source
- Interpretationcitation
Mussel-inspired injectable hydrogels are applicable in bone repair due to their robust tissue adhesive properties, minimally invasive abilities, self-healing capabilities, and tunable cell compatibility.
“Their robust tissue adhesive properties, minimally invasive abilities, devisable self-healing capabilities, and tunable cell compatibility enable mussel-inspired injectable hydrogels to be applied in bone repair [135,136].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [135] Liu, 2020, The characteristics of mussel-inspired nha/osa injectable hydrogel and repaired bone defect in rabbit, J. Biomed. Mater. Res. Part B Appl. Biomater. source
- cites [136] Ma, W.C., Chen, H.R., Cheng, S.Z., Wu, C., Wang, L.S., and Du, M. (2023). Gelatin hydrogel reinforced with mussel-inspired polydopamine-functionalized nanohydroxyapatite for bone regeneration. Int. J. Biol. Macromol., 240. source
- Premisecitation
HA-Cys/PDA hydrogel can release DMOG sustainably for 7 days.
“This injectable composite hydrogel can release dimethyloxalylglycine (DMOG) drugs sustainably for a period of 7 days.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [149] Yegappan, 2019, Nano polydopamine crosslinked thiol-functionalized hyaluronic acid hydrogel for angiogenic drug delivery, Colloids Surf. B Biointerfaces source
- Premisecitation
The shape memory sponge exhibited remarkable hemostatic performance in a rat liver prick hemorrhage model and other deep, narrow, noncompressible hemorrhage models.
“In vivo results show that the shape memory sponge exhibited remarkable hemostatic performance in a rat liver prick hemorrhage model and other deep, narrow, and noncompressible hemorrhage models [112].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [112] Dong, 2022, Injectable shape memory hydroxyethyl cellulose/soy protein isolate based composite sponge with antibacterial property for rapid noncompressible hemorrhage and prevention of wound infection, Int. J. Biol. Macromol. source
- Premisecitation
Hydrogels offer a versatile platform for drug-carrying systems responsive to specific stimuli.
“Hydrogels offer a versatile platform for the creation of drug-carrying systems that are responsive to specific stimuli [143].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [143] Cheng, 2024, Injectable hydrogels as emerging drug-delivery platforms for tumor therapy, Biomater. Sci. source
- Premisecitation
Curcumin-loaded PDAEA-Fe3+ hydrogel showed a slow and sustained release profile over 4 weeks.
“The curcumin-loaded PDAEA-Fe3+ hydrogel showed a slow and sustained release profile in 4 weeks, suggesting the potential of PDAEA-Fe3+ hydrogel in drug delivery [42].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [42] Gong, 2017, Injectable dopamine-modified poly(α,β-aspartic acid) nanocomposite hydrogel as bioadhesive drug delivery system, J. Biomed. Mater. Res. Part A source
- Premisecitation
Novel electrodes prepared from PC-CNF-GG-glycerol hydrogel can accurately detect electrophysiological signals of humans.
“Novel electrodes prepared from this hydrogel can also accurately detect the electrophysiological (EP) signals of humans [44].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [44] Pan, 2019, Mussel-inspired nanocomposite hydrogel-based electrodes with reusable and injectable properties for human electrophysiological signals detection, ACS Sustain. Chem. Eng. source
- Premisecitation
Biological coatings can reduce adhesion between biological tissues.
“Biological coatings can be used to reduce the adhesion between biological tissues [154].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [154] Ward, 2011, Abdominal adhesions: Current and novel therapies, J. Surg. Res. source
- Premisenone given
Direct polymerization of catechol-based monomers to form polymers or hydrogels is usually difficult.
“On the other hand, direct polymerization of catechol-based monomers to form polymers or hydrogels is usually difficult.”
Quote in the paperSubstantial claim - Interpretationreasoning
Mussel-inspired hydrogels are suitable for flexible sensors due to their ability to adhere to biological tissues.
“Mussel-inspired hydrogels, with their ability to adhere to biological tissues, are suitable for application in flexible sensors.”
Quote in the paperNot a substantial claim - Premisecitation
Modified PP meshes (OCMC-DA/CMCS/PP) exhibited effective anti-adhesion properties in vivo in a rat model.
“Through modification, modified PP meshes exhibited effective anti-adhesion properties in vivo in a rat model, showing their potential to be used as postoperative anti-adhesion materials [45].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [45] Hu, 2018, Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair, Biomater. Sci. source
- Premisecitation
Using a specific DOPA derivative, such as DMA, can keep catechol stable even in an oxidation environment.
“For example, methacrylamide dopamine (DMA) can keep catechol stable, even in an oxidation environment [156].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [156] Qian, 2023, Dopamine-based high-transparent hydrogel as bioadhesive for sutureless ocular tissue repair, Adv. Funct. Mater. source
- Premisecitation
PCs with phenolic hydroxyl groups improved adhesion properties of PC-CNF-GG-glycerol hydrogels.
“PCs with phenolic hydroxyl groups improved the adhesion properties of the hydrogels.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [44] Pan, 2019, Mussel-inspired nanocomposite hydrogel-based electrodes with reusable and injectable properties for human electrophysiological signals detection, ACS Sustain. Chem. Eng. source
- Interpretationreasoning
Mussel-inspired injectable hydrogels with strong adhesive capacity can be designed as gel coatings.
“Mussel-inspired injectable hydrogels with strong adhesive capacity can be designed as gel coatings.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 30
- May combine two claims. 69
- The quote only partly states this claim. 2
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationHydrogels are widely applied in various biomedical applications due to their biological tissue-similar structure, biocompatibility, and tunable physical properties.
“By virtue of their biological tissue-similar structure, biocompatibility, and tunable physical properties, hydrogels are widely applied in various biomedical applications [3,25,26].”
Quote in the paperNot a substantial claim1 of 3 sources checked- cites [3] Zhang, 2020, Mussel-inspired hydrogels: From design principles to promising applications, Chem. Soc. Rev. source
- cites [25] Ouyang, 2023, Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications, Adv. Colloid Interface Sci. source
- cites [26] Mahmoudi, C., Tahraoui Douma, N., Mahmoudi, H., Iurciuc, C.E., and Popa, M. (2024). Hydrogels based on proteins cross-linked with carbonyl derivatives of polysaccharides, with biomedical applications. Int. J. Mol. Sci., 25. source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThese proteinaceous glues quickly solidify upon contact with surfaces, forming adhesive plaques featuring remarkable interfacial strength and resilience.
“These proteinaceous glues quickly solidify upon contact with surfaces, forming adhesive plaques featuring remarkable interfacial strength and resilience [2].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [2] Nador, 2019, The chemistry behind catechol-based adhesion, Angew. Chem. Int. Ed. source
The Introduction describes protein-based mussel adhesion and plaques that contact surfaces. Section 3.4 links plaque formation to cross-linking and describes elasticity and self-healing, but it says curing is slow (1–4 hours), contrary to the claim that the glues quickly solidify upon contact. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningCommonly, catechol is protected before polymerization.
“Therefore, commonly, catechol is protected before polymerization [47].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [47] Faure, 2013, Catechols as versatile platforms in polymer chemistry, Prog. Polym. Sci. source
- Rests on an assumption: Catechol is a well-known polymerization inhibitor.
May combine two claims.
PremisecitationYang and coworkers utilized the coordination of Zn2+ with catechol to develop a composite injectable hydrogel (CSG-PEG/DMA/Zn); due to the inherent antibacterial property of Zn2+, the developed injectable hydrogel exhibited antimicrobial properties.
“For example, Yang and coworkers utilized the coordination of Zn2+ with catechol to develop a composite injectable hydrogel (CSG-PEG/DMA/Zn). Due to the inherent antibacterial property of Zn2+, the developed injectable hydrogel exhibited antimicrobial properties [36].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [36] Yang, 2022, Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing, Bioact. Mater. source
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationMehdizadeh and coworkers developed an injectable citrate-based mussel-inspired hydrogel bioadhesive (iCMBA) by oxidation-induced crosslinking; the optimized iCMBA bioadhesive showed a strong adhesive strength of about 123 kPa in lap shear tests, about eight times that of commercial fibrin glue; in wound healing experiments, iCMBA hydrogel bioadhesive effectively sealed wounds on the backs of rats
“For example, Mehdizadeh and coworkers developed an injectable citrate-based mussel-inspired hydrogel bioadhesive (iCMBA) by oxidation-induced crosslinking. The optimized iCMBA bioadhesive showed a strong adhesive strength of about 123 kPa in lap shear tests. Its adhesive strength was about eight times that of commercial fibrin glue. In wound healing experiments, iCMBA hydrogel bioadhesive”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [87] Mehdizadeh, 2012, Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure, Biomaterials source
May combine two claims.
PremisecitationCompared with clinical sutures, tissue adhesives show advantages in ease of use, sealing of air/fluid leakage, and less pain and scars.
“Compared with clinical sutures, tissue adhesives show advantages in ease of use, sealing of air/fluid leakage, and less pain and scars [97,98].”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [97] Taboada, 2020, Overcoming the translational barriers of tissue adhesives, Nat. Rev. Mater. source
- cites [98] Li, 2022, Bioinspired super-strong aqueous synthetic tissue adhesives, Matter source
The Introduction (page unavailable) describes tissue adhesives as alternatives to sutures because of their ease of use, airtight or watertight sealing, and minimal tissue damage. It does not establish that adhesives cause less pain or fewer scars than sutures; the Results’ observation of no excessive scar tissue after B-Seal implantation is not a comparison with sutures. (LLM, conf=0.86)
Experimental — accuracy not yet measured
May combine two claims.
PremisereasoningThese hydrogels are mainly designed as tissue adhesives, hemostatic sealants, nanocomposite gels, drug carriers, hydrogel bioelectrodes, and anti-adhesion gel coatings.
“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
Quote in the paperNot a substantial claim2 of 6 sources checked- cites [61] Li, 2020, Bioinspired double-dynamic-bond crosslinked bioadhesive enables post-wound closure care, Adv. Funct. Mater. source
- cites [87] Mehdizadeh, 2012, Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure, Biomaterials source
- cites [75] Fang, 2021, A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair, Carbohydr. Polym. source
- cites [88] Qiao, 2021, A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings, Bioact. Mater. source
- cites [41] Wang, 2021, Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration, ACS Appl. Mater. Interfaces source
- cites [89] Ma, W.C., Yang, M.L., Wu, C., Wang, S.Y., and Du, M. (2023). Bioinspired self-healing injectable nanocomposite hydrogels based on oxidized dextran and gelatin for growth-factor-free bone regeneration. Int. J. Biol. Macromol., 251. source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationMillions of wounds, either from accidents or surgery operations, are required to be closed to prevent infection and promote healing each year.
“Millions of wounds, either from accidents or surgery operations, are required to be closed to prevent infection and promote healing each year [91].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [91] Ren, 2023, Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure, Sci. Adv. source
May combine two claims.
PremisecitationMussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability.
“Additionally, mussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability [85,86].”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [85] Qi, 2022, Engineering robust Ag-decorated polydopamine nano-photothermal platforms to combat bacterial infection and prompt wound healing, Adv. Sci. source
- cites [86] Pang, 2023, An injectable self-crosslinked wholly supramolecular polyzwitterionic hydrogel for regulating microenvironment to boost infected diabetic wound healing, Adv. Funct. Mater. source
May combine two claims.
PremisecitationWounds treated by sutures often have a risk of infection and are prone to leaving scars after healing.
“In addition, wounds treated by sutures often have a risk of infection [95] and are prone to leaving scars after healing.”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [95] Zou, 2022, Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing, Bioact. Mater. source
May combine two claims.
PremisecitationPDPC hydrogels exhibited high tissue adhesive performance and photothermal and antibacterial properties.
“The PDPC hydrogels exhibited multiple functions, including high tissue adhesive performance and photothermal and antibacterial properties.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [122] Hu, 2023, An all-in-one “4a hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing, Small source
May combine two claims.
PremisecitationThe negative charges of polyphenols activate coagulation factor XII in vivo, initiating a cascade reaction that enhances coagulation.
“Moreover, the negative charges of polyphenols are capable of activating coagulation factor XII in vivo, initiating a cascade reaction that enhances coagulation [119].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [119] Cui, G.H., Guo, X.Y., Su, P., Zhang, T.S., Guan, J., and Wang, C.A. (2023). Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing. Front. Chem., 11. source
May combine two claims.
PremisecitationDiabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS).
“Diabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS) [109,110].”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [109] Zhu, S.Z., Dou, W.G., Zeng, X.J., Chen, X.C., Gao, Y.L., Liu, H.L., and Li, S.D. (2024). Recent advances in the degradability and applications of tissue adhesives based on biodegradable polymers. Int. J. Mol. Sci., 25. source
Section 3.1 (Natural Polymers; page not provided) says high blood sugar causes excessive ROS accumulation in diabetic wounds, supporting the ROS portion. It discusses infection and difficulty healing but does not state that diabetic wounds involve exacerbated inflammation. (LLM, conf=0.88)
Experimental — accuracy not yet measured - cites [110] Zhou, 2023, Dual glucose/ros-sensitive injectable adhesive self-healing hydrogel with photothermal antibacterial activity and modulation of macrophage polarization for infected diabetic wound healing, ACS Mater. Lett. source
May combine two claims.
PremisecitationThe incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity.
“The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity [36,105,106,107].”
Quote in the paperSubstantial claim2 of 4 sources checked- cites [36] Yang, 2022, Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing, Bioact. Mater. source
The Morphology, adhesion, and antioxidation section reports that catechol groups improve hydrogel adhesion. But the Preparation section says zinc ions were introduced to improve antibacterial properties, and the Antibacterial property and cell compatibility section identifies zinc ions as the main antibacterial component. The paper therefore does not support attributing both effects to DOPA or other catechol compounds. (LLM, conf=0.90)
Experimental — accuracy not yet measured - cites [105] Wang, 2023, Multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesives with high stretchability and rapid self-healing for mrsa infected motion skin wound healing, Chem. Eng. J. source
- cites [106] Sun, 2022, Mussel-inspired hydrogel with injectable self-healing and antibacterial properties promotes wound healing in burn wound infection, NPG Asia Mater. source
The Introduction and Adhesive strength tests section say dopamine’s catechol group enhances hydrogel adhesion. The In vitro antibacterial properties section attributes the hydrogel’s antibacterial activity to added ε-polylysine, not to dopamine or other catechol compounds. The source therefore does not support the claimed catechol-derived antimicrobial activity. (LLM, conf=0.90)
Experimental — accuracy not yet measured - cites [107] He, 2020, Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H2O2/ascorbic acid for infected wound closure, Carbohydr. Polym. source
May combine two claims.
PremisecitationPDPC hydrogels exhibit antimicrobial and anti-inflammatory properties due to the DOPA/Cu2+ complex, showing potential in promoting diabetic wound healing.
“In addition, owing to the existence of the DOPA/Cu2+ complex, PDPC hydrogels also exhibit antimicrobial and anti-inflammatory properties, showing great potential in promoting diabetic wound healing [122].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [122] Hu, 2023, An all-in-one “4a hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing, Small source
May combine two claims.
PremisecitationPDPC hydrogels are effective in treating severe hemorrhages from liver injury, carotid artery rupture, and cardiac penetration injury.
“They are effective in treating severe hemorrhages from liver injury, carotid artery rupture, and cardiac penetration injury.”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [122] Hu, 2023, An all-in-one “4a hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing, Small source
May combine two claims.
PremisereasoningMussel-inspired nanocomposite hydrogels have been widely studied and emerged as an essential type in mussel-inspired hemostatic materials.
“Therefore, mussel-inspired nanocomposite hydrogels have been widely studied and emerged as an essential type in mussel-inspired hemostatic materials [123,124,125].”
Quote in the paperNot a substantial claim1 of 3 sources checked- cites [123] Geng, 2020, Mussel-inspired hydrogels for tissue healing, Acta Chim. Sinica source
- cites [124] Wang, 2022, Polycatechol-derived mesoporous polydopamine nanoparticles for combined ros scavenging and gene interference therapy in inflammatory bowel disease, ACS Appl. Mater. Interfaces source
- cites [125] Li, 2023, Emerging materials for hemostasis, Coord. Chem. Rev. source
May combine two claims.
PremisecitationAutologous and allogeneic bone grafts are the most frequently employed clinical techniques for bone repair but have limitations including donor-site defects, immune rejection, and surgical pain.
“Autologous and allogeneic bone grafts are the most frequently employed clinical techniques [129,130]. However, there are still some limitations to these treatments, such as the risk of creating new defects at the donor site, potential immune rejection, and the pain associated with surgical procedures [131,132].”
Quote in the paperNot a substantial claim2 of 4 sources checked- cites [129] Li, 2016, Small molecule inhibition of transforming growth factor beta signaling enables the endogenous regenerative potential of the mammalian calvarium, Tissue Eng. Part A source
The Introduction identifies autologous and allogeneic grafts as current techniques for craniofacial bone reconstruction and describes donor-site morbidity and chronic pain for autologous grafts, plus immunologic rejection for allogeneic bone. It does not say these are the most frequently employed clinical techniques. (LLM, conf=0.86)
Experimental — accuracy not yet measured - cites [130] Chen, X., Wu, T., Bu, Y., Yan, H., and Lin, Q. (2024). Fabrication and biomedical application of alginate composite hydrogels in bone tissue engineering: A review. Int. J. Mol. Sci., 25. source
The Introduction identifies autologous and allogeneic grafting as clinical treatments for bone defects and says allogeneic grafts can cause rejection. Section 4 also describes these transplantation methods as usually used. Neither passage establishes that they are the most frequently employed techniques or identifies donor-site defects and surgical pain as limitations. (LLM, conf=0.86)
Experimental — accuracy not yet measured - cites [131] Kofron, 2006, Bone tissue engineering by gene delivery, Adv. Drug Del. Rev. source
- cites [132] Ye, 2014, The osteochondral dilemma: Review of current management and future trends, ANZ J. Surg. source
May combine two claims.
PremisecitationHydrogels can offer robust mechanical support for cell adhesion and effectively encapsulate bioactive growth factors or cells.
“Hydrogels, serving as versatile polymeric scaffolds, are capable of offering robust mechanical support for cell adhesion and can effectively encapsulate bioactive growth factors or cells [133].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [133] Bai, 2018, Bioactive hydrogels for bone regeneration, Bioact. Mater. source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationChondroitin sulfate is usually used as a material to relieve pain and promote cartilage regeneration.
“Chondroitin sulfate (CS), a natural polysaccharide, is usually used as a material to relieve pain and promote cartilage regeneration [139].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [139] Clegg, 2006, Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis, N. Engl. J. Med. source
The Background (p. 2) says chondroitin sulfate is used to treat osteoarthritis, and the Discussion (p. 13) describes it as a widely used supplement evaluated for knee pain. The paper does not say it promotes cartilage regeneration; its Results (p. 2) also found no significant pain reduction with chondroitin sulfate alone versus placebo. (LLM, conf=0.88)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationCartilage lacks blood vessels, cellular reproduction, and regenerative capacity.
“Unlike regular bone tissue, however, cartilage lacks blood vessels, cellular reproduction, and regenerative capacity [138].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [138] Hua, 2021, Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy, Sci. Adv. source
The Introduction (page unavailable) says articular cartilage defects have a low capacity for self-repair, supporting limited natural repair but not an absolute lack of regenerative capacity. Our copy does not state that cartilage lacks blood vessels or cellular reproduction, or make the comparison with bone tissue. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The quote only partly states this claim.
InterpretationcitationThe catechol group's radical-scavenging capacity makes mussel-inspired hydrogels suitable for eliminating ROS in wound healing.
“On the one hand, this makes the mussel-inspired hydrogel suitable for eliminating ROS in the wound healing process.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [47] Faure, 2013, Catechols as versatile platforms in polymer chemistry, Prog. Polym. Sci. source
Section 2.2 reports radical-scavenging activity for poly(catechin), and section 3.3.4 describes mussel-inspired catechol hydrogels used as tissue sealants. Neither passage establishes that those hydrogels eliminate ROS or are suitable for wound healing on that basis. (LLM, conf=0.83)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationThe catechol group is prone to oxidation, which may reduce adhesive performance and induce accidental crosslinking.
“First, the catechol group is prone to oxidation. The oxidation of catechol may reduce the adhesive performance of mussel-inspired hydrogels, especially for some mineral or metal substrates, and is prone to inducing accidental crosslinking [155].”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [155] Yu, 2011, Mussel protein adhesion depends on interprotein thiol-mediated redox modulation, Nat. Chem. Biol. source
The opening passage following the Abstract states that dopa readily oxidizes to dopaquinone, diminishing adhesion to titania and mica by at least 80% and making further reactions, including cross-linking, likely. The paper supports the proposed mechanism, but the cited passage does not establish reduced adhesive performance specifically in mussel-inspired hydrogels. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationThe catechol group is a polymerization inhibitor that can react with free radicals.
“Second, the catechol group is a polymerization inhibitor with the capacity to react with free radicals [47].”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [47] Faure, 2013, Catechols as versatile platforms in polymer chemistry, Prog. Polym. Sci. source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationMussel-inspired glues exhibit desirable adhesive performance and are applied in numerous fields, including biomedical adhesives, antifouling coatings, flexible electronics, drug delivery, and cell encapsulation and delivery.
“These mussel-inspired glues exhibit desirable adhesive performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc.”
Quote in the paperNot a substantial claim0 of 6 sources checked- cites [14] Du, 2021, Mussel-inspired epoxy bioadhesive with enhanced interfacial interactions for wound repair, Acta Biomater. source
- cites [15] Pan, 2022, Mussel- and barnacle cement proteins-inspired dual-bionic bioadhesive with repeatable wet-tissue adhesion, multimodal self-healing, and antibacterial capability for nonpressing hemostasis and promoted wound healing, Adv. Funct. Mate. source
- cites [16] Li, 2019, Mussel-inspired coatings with tunable wettability, for enhanced antibacterial efficiency and reduced bacterial adhesion, J. Mater. Chem. B source
- cites [17] Imbia, 2024, Mussel-inspired polymer-based coating technology for antifouling and antibacterial properties, Langmuir source
- cites [18] Wang, 2020, Bio-inspired stretchable, adhesive, and conductive structural color film for visually flexible electronics, Adv. Funct. Mater. source
- cites [19] Zhang, 2021, Mussel-inspired adhesive and conductive hydrogel with tunable mechanical properties for wearable strain sensors, J. Colloid Interface Sci. source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenFor mineral or metal surfaces, the adhesion interactions mainly include hydrogen bonding and coordination interaction.
“For mineral or metal surfaces, the adhesion interactions mainly include hydrogen bonding (H-bonding) and coordination interaction.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
PremisereasoningFor organic surfaces, especially biological tissue surfaces, more adhesion interactions may form due to the complicated components of organic surfaces; in addition to H-bonding, π-π interactions and π-cation interactions may exist.
“For organic surfaces, especially biological tissue surfaces, more adhesion interactions may form due to the complicated components of organic surfaces. In addition to H-bonding, π-π interactions and π-cation interactions may exist.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationIn biosynthesis, mushroom tyrosinase, which can convert tyrosine residues to DOPA, is used.
“In this method, mushroom tyrosinase, which can convert tyrosine residues to DOPA, is used [58].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [58] Yang, 2013, A comparative study on the bulk adhesive strength of the recombinant mussel adhesive protein fp-3, Biofouling source
Probably not a substantial claim: may not pass S4 (based).
Premisenone givenThe catechol group is usually considered an adhesive group for the improvement of the interfacial adhesion property of materials.
“The catechol group is usually considered an adhesive group for the improvement of the interfacial adhesion property of materials.”
Quote in the paperNot a substantial claim- Rests on an assumption: The catechol group is usually considered an adhesive group for the improvement of the interfacial adhesion property of materials.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningThe coupled reaction between amino or carboxyl groups is the most used method for incorporating catechol groups into polymers by classic organic reactions.
“The coupled reaction between amino or carboxyl groups is the most used.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationAn in vivo residue-specific incorporation strategy created mussel adhesive proteins with a high DOPA content, showing promise in the production of mussel-inspired macromolecules.
“Recently, an in vivo residue-specific incorporation strategy was proposed. This strategy created mussel adhesive proteins with a high DOPA content [59], showing promise in the production of mussel-inspired macromolecules.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [59] Yang, 2014, In vivo residue-specific dopa-incorporated engineered mussel bioglue with enhanced adhesion and water resistance, Angew. Chem. Int. Ed. source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
PremisereasoningCrosslinking among catechol-containing polymers is a necessary step for developing mussel-inspired injectable adhesive hydrogels.
“Crosslinking among catechol-containing polymers is a necessary step for developing mussel-inspired injectable adhesive hydrogels.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationDue to the instability of the formed imine bond, the sodium borohydride (NaBH4)-mediated reductive amination reaction is usually necessary.
“Due to the instability of the formed imine bond, the sodium borohydride (NaBH4)-mediated reductive amination reaction is usually necessary [49,50].”
Quote in the paperNot a substantial claim0 of 2 sources checkedProbably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenCatechol-metal coordination crosslinking, oxidation-induced catechol-based crosslinking, and dynamic boron ester-based crosslinking are the three main crosslinking ways for catechol-mediated crosslinking.
“Catechol–metal coordination crosslinking, oxidation-induced catechol-based crosslinking, and dynamic boron ester-based crosslinking are the three main crosslinking ways.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenCrosslinking strategies for mussel-inspired injectable adhesive hydrogels can be divided into catechol-mediated crosslinking and other regular crosslinking when considering whether the catechol group plays a major role in crosslinking.
“When considering whether the catechol group plays a major role in crosslinking, crosslinking strategies can be divided into catechol-mediated crosslinking and other regular crosslinking.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenBiosynthesis is a method of developing catechol-containing proteins similar to mussel adhesive proteins.
“Biosynthesis is a method of developing catechol-containing proteins similar to mussel adhesive proteins.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationIn oxidation conditions, the catechol group can transfer to a quinone structure; the formed quinone is capable of reacting with the -NH2 group and -SH group, thus improving the crosslinking density.
“In addition, in oxidation conditions, the catechol group can transfer to a quinone structure. The formed quinone is capable of reacting with the -NH2 group and -SH group, thus improving the crosslinking density [13].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [13] Nam, 2021, Polymeric tissue adhesives, Chem. Rev. source
May combine two claims.
PremisecitationSato and coworkers showed that in a weakly alkaline environment (pH 7.4), HA-CA with a high molar mass and catechol content was capable of self-assembly into a crosslinked network within about three hours without the addition of additional enzymes or oxidizing agents; this gelation process was mainly due to the oxidation-induced coupling of the catechol groups.
“They showed that in a weakly alkaline environment (pH 7.4), HA-CA, with a high molar mass and catechol content, was capable of self-assembly into a crosslinked network within about three hours without the addition of additional enzymes or oxidizing agents. This gelation process was mainly due to the oxidation-induced coupling of the catechol groups [66].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [66] Sato, 2017, Catechol-modified hyaluronic acid: In situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light, Polym. Bull. source
May combine two claims.
PremisecitationShin and coworkers showed that HA-CA can form a hydrogel after the addition of NaIO4; gelation was considered to be induced by the formation of catechol-catechol adducts due to the oxidation of catechol.
“For example, Shin and coworkers synthesized catechol-modified hyaluronic acid (HA-CA) and showed that HA-CA can form a hydrogel after the addition of NaIO4. Gelation was considered to be induced by the formation of catechol–catechol adducts due to the oxidation of catechol [67].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [67] Shin, 2015, Tissue adhesive catechol-modified hyaluronic acid hydrogel for effective, minimally invasive cell therapy, Adv. Funct. Mater. source
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenIn the development of mussel-inspired injectable adhesive hydrogels, the catechol group is also widely used as a functional group for crosslinking of hydrogels.
“In the development of mussel-inspired injectable adhesive hydrogels, the catechol group is also widely used as a functional group for crosslinking of hydrogels (Figure 5).”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationLi and coworkers developed a Fe3+-crosslinked catechol-modified ε-polylysine adhesive hydrogel; by rationally tuning the pH and Fe3+ content in the gelation condition, the resultant adhesive hydrogels exhibited high adhesive strength.
“For example, Li and coworkers developed a Fe3+-crosslinked catechol-modified ε-polylysine adhesive hydrogel. By rationally tuning the pH and Fe3+ content in the gelation condition, the resultant adhesive hydrogels exhibited high adhesive strength [65].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [65] Li, 2020, Metal-crosslinked ε-poly-l-lysine tissue adhesives with high adhesive performance: Inspiration from mussel adhesive environment, Int. J. Biol. Macromol. source
May combine two claims. The quote only partly states this claim.
PremisecitationDeng and coworkers prepared a mussel-inspired Alg-DA-CATNFC-PAM-Al3+DN hydrogel crosslinked by triple dynamic interactions, including coordination, hydrogen bonding, and electrostatic interaction; it exhibited exceptional mechanical properties and self-healing properties, and upon application at the wound site it effectively closed a 3 cm-long incision on the back of a rat and facilitated wound
“Deng and coworkers prepared a mussel-inspired Alg-DA-CATNFC-PAM-Al3+DN hydrogel, which was composed of alginate-modified dopamine (Alg-DA), a copolymer of acrylamide and acrylic acid (PAM), and cationized nanofibrillated cellulose (CATNFC). The Alg-DA-CATNFC-PAM-Al3+DN hydrogel was crosslinked by triple dynamic interactions, including coordination, hydrogen bonding, and electrostatic interaction,”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [99] Deng, 2021, A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing, ACS Sustain. Chem. Eng. source
May combine two claims.
PremisecitationThe introduction of noncovalent interactions into the gel network not only enhances the structural integrity of the hydrogel networks but also endows these materials with additional characteristics, such as self-healing capabilities.
“The introduction of noncovalent interactions into the gel network not only enhances the structural integrity of the hydrogel networks but also endows these materials with additional characteristics, such as self-healing capabilities [72].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [72] Han, 2017, A mussel-inspired conductive, self-adhesive, and self-healable tough hydrogel as cell stimulators and implantable bioelectronics, Small source
May combine two claims.
PremisecitationSince the catechol group can chelate with Fe3+ under weakly alkaline conditions, coordination crosslinking is often used in the design of multiple crosslinked hydrogels.
“Since the catechol group can chelate with Fe3+ under weakly alkaline conditions [100], coordination crosslinking is often used in the design of multiple crosslinked hydrogels.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [100] Li, 2020, Environment-dependent adhesive behaviors of mussel-inspired coordinate-crosslinked bioadhesives, Macromol. Mater. Eng. source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenCovalent crosslinking is the predominant method for developing mussel-inspired injectable gels.
“Covalent crosslinking is the predominant method for developing mussel-inspired injectable gels.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisereasoningThe catechol group is a reactive oxygen species (ROS) scavenger; therefore, mussel-inspired adhesive hydrogels usually exhibit antioxidant properties.
“Second, the catechol group is a reactive oxygen species (ROS) scavenger. Therefore, the mussel-inspired adhesive hydrogels usually exhibit antioxidant properties [83,84].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [83] Zhao, 2020, Physical double-network hydrogel adhesives with rapid shape adaptability, fast self-healing, antioxidant and NIR/pH stimulus-responsiveness for multidrug-resistant bacterial infection and removable wound dressing, Adv. Funct. Mater. source
- cites [84] Chen, Y.A., Zhang, Y., Chang, L.M., Sun, W.C., Duan, W.H., and Qin, J.L. (2023). Mussel-inspired self-healing hydrogel form pectin and cellulose for hemostasis and diabetic wound repairing. Int. J. Biol. Macromol., 246. source
May combine two claims.
PremisecitationShan and coworkers developed a mussel-inspired PEG-based hydrogel containing catechol-modified four-armed PEG (4-arm-PEG-DA) and phenylboronic acid-functionalized four-armed PEG (4-arm-PEG-PBA); at pH 9.0, mixing the two modified PEGs led to the fast formation of a PEG-based hydrogel by boron ester-based crosslinking.
“For example, Shan and coworkers developed a mussel-inspired polyethylene glycol (PEG)-based hydrogel. The hydrogel contained catechol-modified four-armed PEG (4-arm-PEG-DA) and phenylboronic acid-functionalized four-armed PEG (4-arm-PEG-PBA). At pH 9.0, mixing the two modified PEGs led to the fast formation of a PEG-based hydrogel by boron ester-based crosslinking (borate–catechol complexation) [”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [69] Shan, 2017, A ph, glucose, and dopamine triple-responsive, self-healable adhesive hydrogel formed by phenylborate-catechol complexation, Polym. Chem. source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisenone givenThe most used reactions in covalent crosslinking include the Schiff base reaction between amino and aldehyde groups and the Michael addition between sulfhydryl and double bonds.
“The most used reactions in covalent crosslinking include the Schiff base reaction between amino and aldehyde groups and the Michael addition between sulfhydryl and double bonds.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationZhou and coworkers synthesized sulfhydryl-modified chitosan (CSS) and catechol and maleimide-functionalized ε-polylysine (Catechol-PL-MAL); after mixing at pH 7.2, the Michael addition between the sulfhydryl in CSS and maleimide in Catechol-PL-MAL induced gelation; in this type of gelation, the catechol group was not the major group in crosslinking, so more catechol groups can participate in the
“For example, Zhou and coworkers synthesized sulfhydryl-modified chitosan (CSS) and catechol and maleimide-functionalized ε-polylysine (Catechol-PL-MAL). After mixing CSS and Catechol-PL-MAL at pH 7.2, the Michael addition between the sulfhydryl in CSS and maleimide in Catechol-PL-MAL induced the gelation of the hydrogel [70]. In this type of gelation, the catechol group was not the major group in”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [70] Zhou, 2016, Rapid gelling chitosan/polylysine hydrogel with enhanced bulk cohesive and interfacial adhesive force: Mimicking features of epineurial matrix for peripheral nerve anastomosis, Biomacromolecules source
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenSuturing can stably close wounds.
“Suturing can stably close wounds.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationHu and coworkers developed mussel-inspired hydrogels based on chitosan quaternary ammonium salt (HTCC) and oxidized dextran-dopamine (OD-DA); the hydrogel was double-crosslinked by catechol-catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC; owing to the double-crosslinking, the hydrogel exhibited great mechanical properties.
“For example, Hu and coworkers developed mussel-inspired hydrogels based on chitosan quaternary ammonium salt (HTCC) and oxidized dextran–dopamine (OD-DA). The hydrogel was double-crosslinked by the catechol–catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC. Owing to the double-crosslinking, the hydrogel exhibited great mechanical properties [”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [73] Hu, 2021, Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release, Chem. Eng. J. source
Classified as probably not a substantial claim.
Premisenone givenThe presence of moisture on tissue surfaces often limits the adhesive strength of traditional hydrogels.
“The presence of moisture on tissue surfaces often limits the adhesive strength of traditional hydrogels.”
Quote in the paperSubstantial claimMay combine two claims.
PremisereasoningMultiple crosslinked structures can endow the hydrogel with multiple functions, thus benefiting wound treatment.
“In addition, the multiple crosslinked structures can endow the hydrogel with multiple functions, thus benefiting wound treatment.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based). May combine two claims.
Premisenone givenCurrent regular tissue adhesives usually show weak mechanical and adhesive strength, and their prices are relatively high.
“However, current regular tissue adhesives usually show weak mechanical and adhesive strength, and their prices are relatively high.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationOwing to the existence of the catechol group, mussel-inspired adhesive hydrogels can be easily formed by coordination bonds or other noncovalent interactions; since these interactions are reversible, the obtained hydrogels usually show self-healing properties.
“First, owing to the existence of the catechol group, mussel-inspired adhesive hydrogels can be easily formed by coordination bonds or other noncovalent interactions. Since these interactions are reversible, the obtained hydrogels usually show self-healing properties [81,82].”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
PremisecitationSuturing consumes much time and causes secondary damage to tissues surrounding wounds.
“However, it consumes much time and causes secondary damage to tissues surrounding wounds [93,94].”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [93] Bhagat, 2017, Degradable adhesives for surgery and tissue engineering, Biomacromolecules source
- cites [94] Li, S., Dou, W., Zhu, S., Zeng, X., Ji, W., Li, X., Chen, N., Li, Y., Liu, C., and Fan, H. (2024). Epidermal growth factor-loaded, dehydrated physical microgel-formed adhesive hydrogel enables integrated care of wet wounds. Int. J. Biol. Macromol., 275. source
May combine two claims.
PremisecitationTraditional surgical suturing remains a dominant method for hemostasis but is often criticized for time-consuming operations and secondary tissue damage.
“Nowadays, traditional surgical suturing remains a dominant method for hemostasis. However, it is often criticized for its time-consuming operations and secondary tissue damage [115].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [115] Yang, 2023, Biomimetic natural biopolymer-based wet-tissue adhesive for tough adhesion, seamless sealed, emergency/nonpressing hemostasis, and promoted wound healing, Adv. Funct. Mater. source
May combine two claims.
PremisecitationIn vivo, CCS@gel rapidly covered the injury site and significantly lowered blood loss.
“In vivo studies show that CCS@gel rapidly covered the injury site and significantly lowered the loss of bleeding [75].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [75] Fang, 2021, A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair, Carbohydr. Polym. source
May combine two claims.
PremisereasoningShape memory hemostatic sponges can quickly absorb blood, creating a physical barrier that effectively seals wounds.
“These sponges can quickly absorb blood, thereby creating a physical barrier that effectively seals wounds.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationCCS@gel showed high mechanical performance and self-healing properties.
“In addition, the hydrogel showed high mechanical performance and self-healing properties.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [75] Fang, 2021, A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair, Carbohydr. Polym. source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe healing of diabetic wounds is a significant challenge in clinical practice.
“The healing of diabetic wounds is a significant challenge in clinical practice [73].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [73] Hu, 2021, Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release, Chem. Eng. J. source
May combine two claims.
PremisecitationFu and coworkers developed a series of tannin-europium coordination complexes (TECs) crosslinked with citrate-based mussel-inspired bioadhesives (TE-CMBAs); the incorporation of TEC improved the antioxidant and anti-inflammatory capabilities of the hydrogel adhesives; in vivo results show that TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis, enhance
“Fu and coworkers developed a series of tannin–europium coordination complexes (TECs) crosslinked with citrate-based mussel-inspired bioadhesives (TE-CMBAs). The incorporation of TEC improved the antioxidant and anti-inflammatory capabilities of the hydrogel adhesives. In vivo results show that the TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis,”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [111] Fu, 2023, On-demand removable self-healing and pH-responsive europium-releasing adhesive dressing enables inflammatory microenvironment modulation and angiogenesis for diabetic wound healing, Small source
May combine two claims.
PremisecitationWang and coworkers developed mussel-inspired catechol-modified ε-polylysine-polyethylene glycol-based hydrogel (PPD hydrogel) by horseradish peroxidase (HRP)-mediated crosslinking; the existence of adjacent catechol-lysine in PPD hydrogel enabled the hydrogel to work in a wet environment; the adhesive strength of optimized PPD hydrogel reached up to about 147 kPa; in vivo studies indicated that
“For example, Wang and coworkers developed mussel-inspired catechol-modified ε-polylysine–polyethylene glycol-based hydrogel (PPD hydrogel) by horseradish peroxidase (HRP)-mediated crosslinking. The existence of adjacent catechol–lysine in PPD hydrogel enabled the hydrogel to work in a wet environment. The adhesive strength of optimized PPD hydrogel reached up to about 147 kPa. In vivo studies”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [104] Wang, 2017, A biomimetic mussel-inspired ε-poly-l-lysine hydrogel with robust tissue-anchor and anti-infection capacity, Adv. Funct. Mater. source
May combine two claims.
PremisereasoningTraditional hemostatic powders may disperse with blood flow and risk inducing thrombosis, and their efficacy in deep and incompressible wounds requires improvement.
“For example, they may disperse with the flow of blood and, therefore, have the risk of inducing thrombosis. Additionally, their efficacy in addressing bleeding from deep and incompressible wounds still requires improvement.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based). May combine two claims.
Premisenone givenInjured skin is particularly vulnerable to bacterial infections, which result in wound inflammation and delayed healing.
“Injured skin is particularly vulnerable to bacterial infections, which result in wound inflammation and delayed healing.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThe polydopamine-coated injectable hemostatic material (EHP) shape memory sponge re-expands after absorbing blood and serves as a robust physical barrier for stopping bleeding.
“Its unique ability to re-expand after absorbing blood allowed the shape memory sponge to serve as a robust physical barrier for stopping bleeding.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [112] Dong, 2022, Injectable shape memory hydroxyethyl cellulose/soy protein isolate based composite sponge with antibacterial property for rapid noncompressible hemorrhage and prevention of wound infection, Int. J. Biol. Macromol. source
May combine two claims.
PremisecitationThe Laponite XLG-containing hydrogel reduced hemostasis time and lowered blood loss in a liver-bleeding mouse model.
“In hemostatic experiments, the hydrogel was found to be capable of reducing hemostasis time and lowering the loss of blood in a liver-bleeding mouse model [126].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [126] Xu, L., Jiao, G.H., Huang, Y.L., Ren, P.F., Liang, M., Wei, D.D., and Zhang, T.Z. (2024). Laponite nanoparticle-crosslinked carboxymethyl cellulose-based injectable hydrogels with efficient underwater-specific adhesion for rapid hemostasis. Inter. J. Biol. Macromol., 255. source
May combine two claims.
PremisecitationGuo and coworkers developed antimicrobial mussel-inspired hydrogels based on catechol-functionalized oxidized hyaluronic acid (OHAdop), guar gum (GG), glycol chitosan (GC), borax, and polydopamine nanoparticles (PDA NPs); due to the photothermal antimicrobial properties of PDA NPs, the developed hydrogels exhibited good antimicrobial properties under near-infrared (NIR) irradiation (808 nm), and
“For example, Guo and coworkers developed antimicrobial mussel-inspired hydrogels based on catechol-functionalized oxidized hyaluronic acid (OHAdop), guar gum (GG), glycol chitosan (GC), borax, and polydopamine nanoparticles (PDA NPs). In addition to their robust tissue adhesive properties, injectability, and self-healing capabilities, due to the photothermal antimicrobial properties of PDA NPs,”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [108] Guo, 2022, Injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel with photothermal antibacterial activity for infected wound healing, Chem. Mater. source
May combine two claims.
PremisereasoningThis leads to the leakage of wound tissue fluid, which further fosters pathogen proliferation and results in persistent wound inflammation, non-healing, or recurrence.
“This leads to the leakage of wound tissue fluid, which further fosters pathogen proliferation and results in persistent wound inflammation, non-healing, or recurrence.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationCompared with untreated controls, the nHA/PLGA-BP-Dex DC hydrogel-treated group showed higher bone volume percentage, bone mineral density, and trabecular number.
“Compared with the control group (untreated), the nHA/PLGA-BP-Dex DC hydrogel-treated group showed a higher percentage of bone volume, bone mineral density, and trabecular number [41].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [41] Wang, 2021, Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration, ACS Appl. Mater. Interfaces source
May combine two claims.
PremisecitationGO-PHA-CP hydrogels exhibit self-healing, injectability, tissue adhesiveness, antioxidant activity, and osteoinductive properties.
“The GO-PHA-CP hydrogels were formed by Schiff base crosslinking and exhibited self-healing abilities, injectability, tissue adhesiveness, antioxidant activity, and osteoinductive properties.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [89] Ma, W.C., Yang, M.L., Wu, C., Wang, S.Y., and Du, M. (2023). Bioinspired self-healing injectable nanocomposite hydrogels based on oxidized dextran and gelatin for growth-factor-free bone regeneration. Int. J. Biol. Macromol., 251. source
May combine two claims.
PremisecitationThe nHA/PLGA-BP-Dex DC hydrogel has tissue adhesive properties, self-healing capacity, and osteoconductivity due to catechol and BP groups.
“The incorporation of catechol and BP groups endowed the composite hydrogel with tissue adhesive properties, self-healing capacity, and osteoconductivity.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [41] Wang, 2021, Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration, ACS Appl. Mater. Interfaces source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationNanodrug delivery systems can deliver therapeutic agents precisely to the intended target.
“These nanocarriers possess the ability to deliver therapeutic agents precisely to the intended target.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [142] Qin, 2017, Drug self-delivery systems for cancer therapy, Biomaterials source
May combine two claims.
PremisecitationGMAD/LP hydrogel exhibits high tissue adhesiveness, robust mechanical strength, injectability, and self-healing abilities.
“The GMAD/LP hydrogel exhibited high tissue adhesiveness, robust mechanical strength, injectability, and self-healing abilities.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [40] Wu, 2023, Engineering mussel-inspired multifunctional nanocomposite hydrogels to orchestrate osteoimmune microenvironment and promote bone healing, Mater. Des. source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationAn ideal hydrogel for bone regeneration exhibits exceptional biocompatibility and osteoconductivity and creates a microenvironment that fosters cell adhesion, proliferation, and differentiation, guiding and accelerating tissue regeneration.
“Meanwhile, the ideal hydrogel for bone regeneration exhibits exceptional biocompatibility and osteoconductivity. It creates an advantageous microenvironment that fosters cell adhesion, proliferation, and differentiation, which further guides and accelerates the tissue regeneration process [134].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [134] Munarin, 2011, Pectin-based injectable biomaterials for bone tissue engineering, Biomacromolecules source
Classified as probably not a substantial claim. May combine two claims.
Premisenone givenConventional nanocarrier systems often have suboptimal targeting accuracy and risk premature drug release.
“However, conventional nanocarrier systems often have some limitations, including suboptimal targeting accuracy and the risk of premature drug release.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationIn the tumor microenvironment, DOX-loaded PBA-MSNs are released from NP-gel, while in adjacent normal tissue the NP-gel remains dormant.
“In the tumor microenvironment, which is mildly acidic and rich in hyaluronidase, DOX-loaded PBA-MSNs are released, and in the adjacent normal tissue, the NP-gel remains dormant.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [150] Wu, 2019, An injectable and tumor-specific responsive hydrogel with tissue-adhesive and nanomedicine-releasing abilities for precise locoregional chemotherapy, Acta Biomater. source
May combine two claims.
PremisecitationIn vivo, NP-gel effectively inhibits tumor recurrence and avoids severe toxicity to healthy organs.
“In vivo studies show that the NP-gel can effectively inhibit tumor recurrence and avoid severe toxicity to healthy organs [150].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [150] Wu, 2019, An injectable and tumor-specific responsive hydrogel with tissue-adhesive and nanomedicine-releasing abilities for precise locoregional chemotherapy, Acta Biomater. source
May combine two claims.
PremisecitationAfter encapsulation of exosomes, AD/CS/RSF hydrogels recruit migration and proliferation of BMSCs and promote their differentiation into chondrocytes, accelerating healing of cartilage defects in rat knee joints.
“The hydrogels, after encapsulated exosomes, showed the ability to recruit the migration and inflation of bone marrow stem cells (BMSCs). They also promoted the proliferation and differentiation of BMSCs into chondrocytes, thereby effectively accelerating the healing of cartilage defects in rat knee joints [140].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [140] Zhang, F.X., Liu, P., Ding, W., Meng, Q.B., Su, D.H., Zhang, Q.C., Lian, R.X., Yu, B.Q., Zhao, M.D., and Dong, J. (2021). Injectable mussel-inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 278. source
May combine two claims.
PremisecitationCMC-based hydrogel exhibited tissue adhesive properties with highest adhesive strength about 9.7 kPa.
“The CMC-based hydrogel exhibited tissue adhesive properties, and its highest adhesive strength was about 9.7 kPa.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [90] Zhao, 2021, Chitosan derivative-based mussel-inspired hydrogels as the dressings and drug delivery systems in wound healing, Cellulose source
May combine two claims.
PremisecitationBi2Se3-DOX@PDA hydrogel can be administered precisely via intra-tumoral injection and remains at the injection site for at least 12 days.
“The Bi2Se3-DOX@PDA hydrogel can be administered precisely via intra-tumoral injection and remains at the site of injection for at least 12 days.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [151] Liu, Q.Y., Yang, L., Wang, L.L., Li, Z.M., Yu, Y.K., Zheng, Y., Lian, D.Z., Li, X.M., Chen, H.Z., and Mei, L. (2023). An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy. Int. J. Biol. Macromol., 244. source
May combine two claims.
Premisenone givenConventional preformed hydrogels often fail to fully adhere to irregular wound sites, risking coating detachment.
“However, conventional preformed hydrogels often fail to fully adhere to irregular wound sites, which have the risk of coating detachment.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationStimuli-responsive hydrogels can respond to environmental stimuli and be applied in detection of biological signals.
“Stimuli-responsive hydrogels can respond to a variety of environmental stimuli [152,153] and, therefore, can be applied in the detection of some biological signals.”
Quote in the paperNot a substantial claim0 of 2 sources checkedClassified as probably not a substantial claim.
Interpretationnone givenMussel-inspired injectable adhesive hydrogels combine the minimally invasive property of injectable hydrogels and the properties of mussel-inspired materials.
“These adhesive hydrogels combine the advantage of the minimally invasive property of injectable hydrogels and the fascinating properties of mussel-inspired materials.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe strain sensor derived from PC-CNF-GG-glycerol hydrogel demonstrated low-weight detection capability (200 mg) and fast response time (33 ms).
“The strain sensor derived from this hydrogel demonstrated a low-weight detection capability (200 mg) and a fast response time (33 ms).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [44] Pan, 2019, Mussel-inspired nanocomposite hydrogel-based electrodes with reusable and injectable properties for human electrophysiological signals detection, ACS Sustain. Chem. Eng. source
Probably not a substantial claim: may not pass S2 (checkable), S4 (based).
InterpretationreasoningThe desirable properties of mussel-inspired injectable adhesive hydrogels facilitate the development of these fields.
“The desirable properties of mussel-inspired injectable adhesive hydrogels facilitate the development of these fields.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationBi2Se3-DOX@PDA NSs possess a photothermal effect and can release DOX in a controlled manner.
“The Bi2Se3-DOX@PDA NSs possess a photothermal effect and can release DOX in a controlled manner.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [151] Liu, Q.Y., Yang, L., Wang, L.L., Li, Z.M., Yu, Y.K., Zheng, Y., Lian, D.Z., Li, X.M., Chen, H.Z., and Mei, L. (2023). An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy. Int. J. Biol. Macromol., 244. source
Probably not a substantial claim: may not pass S4 (based).
Premisenone givenMussel-inspired injectable adhesive hydrogels have been widely applied in biomedical fields including wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.
“Nowadays, mussel-inspired injectable adhesive hydrogels have been widely applied in many biomedical fields, including wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, biological coatings, etc.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationSome studies have successfully polymerized catechol-based monomers by tuning polymerization conditions, but the detailed mechanism remains elusive.
“Although some studies have successfully polymerized catechol-based monomers by tuning the polymerization conditions [57], the detailed mechanism is still elusive.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [57] White, 2013, Switching the adhesive state of catecholic hydrogels using phototitration, Macromolecules source
May combine two claims.
PremisecitationBi2Se3-DOX@PDA hydrogel demonstrates remarkable therapeutic efficacy in T1 xenograft tumors and minimal systemic side effects.
“It also demonstrates remarkable therapeutic efficacy in T1 xenograft tumors and minimal systemic side effects [151].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [151] Liu, Q.Y., Yang, L., Wang, L.L., Li, Z.M., Yu, Y.K., Zheng, Y., Lian, D.Z., Li, X.M., Chen, H.Z., and Mei, L. (2023). An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy. Int. J. Biol. Macromol., 244. source
May combine two claims.
PremisereasoningThe catechol group is generally required to be protected by alkyl silanes and nitrobenzyl before polymerization, which increases preparation difficulty.
“In general, the catechol group is required to be protected by alkyl silanes and nitrobenzyl before polymerization. However, this method increases the difficulty in the preparation of mussel-inspired materials.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
The main functional group in DOPA is the catechol group.
“The main functional group in DOPA is the catechol group, which can form multiple covalent and noncovalent interactions with specific surfaces [9,10,11] (Figure 1).”
The paper relies on this without support.
Catechol is a well-known polymerization inhibitor.
“Catechol is a well-known polymerization inhibitor.”
The paper relies on this without support.
The catechol group is usually considered an adhesive group for the improvement of the interfacial adhesion property of materials.
“The catechol group is usually considered an adhesive group for the improvement of the interfacial adhesion property of materials.”
The paper relies on this without support.
Hemorrhage control is typically achieved through the formation of a barrier that effectively seals the site of bleeding.
“First, hemorrhage control is typically achieved through the formation of a barrier that effectively seals the site of bleeding.”
The paper relies on this without support.
A robust hemostatic barrier requires a hemostatic agent with exceptional adhesive strength in the presence of blood and adequate mechanical strength to firmly seal the wound without breakage.
“A robust hemostatic barrier requires a hemostatic agent with exceptional adhesive strength in the presence of blood and adequate mechanical strength to firmly seal the wound without breakage.”
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“Over recent decades, extensive efforts have been made to understand the intricate compositions and adhesive mechanisms of these mussel-derived proteins [3–5].”
BackgroundThe chemistry behind catechol-based adhesion
Saiz‐Poseu, J., Mancebo‐Aracil, J., Nador, F., Busqué, F., & Ruiz‐Molina, D. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201801063 · Cited by 850 · see citing works
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“Therefore, the mussel-inspired adhesive hydrogels usually exhibit antioxidant properties [83,84].”
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“…to a quinone structure [12]. surface of biological tissues through Schi ff base reaction Under this circumstance, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition [13]. or Michael addition [13].”
BackgroundInfluentialAdaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement
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“Recent studies show that the synergistic effect of cation and catechol promoted wet adhesion [102,103].”
BackgroundSupramolecular Adhesive Hydrogels for Tissue Engineering Applications
Zhao, Y., Song, S., Ren, X., Zhang, J., Lin, Q., & Zhao, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00815 · Cited by 714 · cited 1× · see citing works
“With the development of adhesive hydrogels, in addition to mussel-inspired adhesive hydrogels, many other types of adhesive hydrogels have been reported for biomedical applications [78–80].”
BackgroundHan, L., Lu, X., Wang, M., Gan, D., Deng, W., Wang, K., Fang, L., Liu, K., Chan, C. W., Tang, Y., et al. (2017) · Small · doi:10.1002/smll.201601916 · Cited by 699 · cited 1× · see citing works
“The introduction of noncovalent interactions into the gel network not only enhances the structural integrity of the hydrogel networks but also endows these materials with additional characteristics, such as self-healing capabilities [72].”
BackgroundCatechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
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“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
BackgroundMussel-inspired hydrogels: From design principles to promising applications
Zhang, C., Wu, B., Zhou, Y., Zhou, F., Liu, W., & Wang, Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00849g · Cited by 653 · cited 3× · see citing works
“Over recent decades, extensive efforts have been made to understand the intricate compositions and adhesive mechanisms of these mussel-derived proteins [3–5].”
BackgroundMethodBioinspired underwater adhesives by using the supramolecular toolbox
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BackgroundRecent approaches in designing bioadhesive materials inspired by mussel adhesive protein
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“…the first step to developing mussel-inspired injectable hydrogels. many methods have been developed to incorporate the catechol group into polymers [4,47], including the incorporation of During recent decades, many methods have been developed to incorporate the catechol group into polymers [4,47],…”
MethodCatechols as versatile platforms in polymer chemistry
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“…first step to developing mussel-inspired injectable hydrogels. many methods have been developed to incorporate the catechol group into polymers [4,47], including the incorporation of During recent decades, many methods have been developed to incorporate the catechol group into polymers [4,47],…”
BackgroundMethodInfluentialRecent advances in wet adhesives: Adhesion mechanism, design principle and applications
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“The main functional group in DOPA is the catechol group, which can form multiple covalent and noncovalent interactions with specific surfaces [9–11] (Figure 1).”
BackgroundBioactive hydrogels for bone regeneration
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“Recent studies have shed light on the remarkable effectiveness of catechol for adhesion to wet tissues [117,118].”
BackgroundRecent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering
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“In recent years, nanodrug delivery systems (NDDSs) have become innovative tools for targeted drug delivery [142].”
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“Additionally, mussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability [85,86].”
BackgroundStrong reversible Fe <sup>3+</sup> -mediated bridging between dopa-containing protein films in water
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“In vivo studies indicated that the PPD hydrogel was effective in promoting wound repair and skin regeneration [104].”
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Mussel protein adhesion depends on interprotein thiol-mediated redox modulation
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“The thiol group has been reported to be able to restore dopa from oxidized dopaquinone [155].”
BackgroundOvercoming the translational barriers of tissue adhesives
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“Gelation was considered to be induced by the formation of catechol–catechol adducts due to the oxidation of catechol [67].”
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Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review
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“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion…”
BackgroundRecent advances of self-assembling peptide-based hydrogels for biomedical applications
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Recent progress in synthesis and application of mussel-inspired adhesives
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“The main functional group in DOPA is the catechol group, which can form multiple covalent and noncovalent interactions with specific surfaces [9–11] (Figure 1).”
BackgroundSupramolecular engineering of hydrogels for drug delivery
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“Traditional administration routes, such as oral or intravenous delivery, may sometimes restrict the efficacy of drugs [141].”
BackgroundUltrafast Self‐Gelling and Wet Adhesive Powder for Acute Hemostasis and Wound Healing
Peng, X., Xu, X. G., Deng, Y., Xie, X. N., Xu, L., Xu, X., Yuan, W., Yang, B., Yang, X., Xia, X., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102583 · Cited by 363 · cited 1× · see citing works
“Hemorrhage from irregularly shaped and deep wounds is especially severe in emergency care [114].”
BackgroundDopamine-Modified Hyaluronic Acid Hydrogel Adhesives with Fast-Forming and High Tissue Adhesion
Zhou, D. G., Li, S., Pei, M., Yang, H., Gu, S., Tao, Y., Ye, D., Zhou, Y., Xu, W., & Xiao, P. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22120 · Cited by 350 · cited 1× · see citing works
“This method utilizes the Schi ff base reactions between the aldehyde polysaccharides and 3,4-dihydroxyphenethylamine [48] or between 3,4-dihydroxybenzaldehyde and amino-containing polysaccharides [49].”
MethodSelf-citationDegradable adhesives for surgery and tissue engineering
Bhagat, V., & Becker, M. L. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00969 · Cited by 347 · see citing works
Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion
Li, Z., Milionis, A., Zheng, Y., Yee, M. Y. F., Codispoti, L. A., Tan, F., Dimos Poulikakos, A., & Yap, C. H. (2019) · Nature Communications · doi:10.1038/s41467-019-13512-8 · Cited by 329 · cited 1× · see citing works
“Uncontrolled hemorrhage and subsequent wound infection are major problems in trauma treatment [112,113].”
BackgroundHu, C., Long, L., Cao, J., Zhang, S., & Wang, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.128564 · Cited by 329 · cited 3× · see citing works
“The hydrogel was double-crosslinked by the catechol–catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC. Owing to the double-crosslinking, the hydrogel exhibited great mechanical properties [73].”
BackgroundMethodInfluentialZhang, F.-X., Liu, P., Ding, W., Meng, Q.-B., Su, D.-H., Zhang, Q.-C., Lian, R.-X., Yu, B.-Q., Zhao, M.-D., Dong, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121169 · Cited by 328 · cited 1× · see citing works
“They also promoted the proliferation and differentiation of BMSCs into chondrocytes, thereby effectively accelerating the healing of cartilage defects in rat knee joints [140].”
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Biomedical applications of hydrogels in drug delivery system: An update
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“For decades, hydrogels have been recognized for their critical role in drug delivery to minimize the drawbacks associated with conventional drug delivery systems [144].”
BackgroundZou, C.-Y., Lei, X.-X., Hu, J.-J., Jiang, Y.-L., Li, Q.-J., Song, Y.-T., Zhang, Q.-Y., Li-Ling, J., & Xie, H.-Q. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.034 · Cited by 287 · see citing works
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“…biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc.…”
BackgroundPan, G., Li, F., He, S., Li, W., Wu, Q., He, J., Ruan, R., Xiao, Z., Zhang, J., & Yang, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202200908 · Cited by 275 · cited 2× · see citing works
“…[ These mussel-inspired glues exhibit desirable adhesive performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15],…”
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“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion…”
BackgroundLu, S., Zhang, X., Tang, Z., Xiao, H., Zhang, M., Liu, K., Chen, L., Huang, L., Ni, Y., & Wu, H. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129329 · Cited by 266 · cited 1× · see citing works
“Recent studies have shed light on the remarkable effectiveness of catechol for adhesion to wet tissues [117,118].”
BackgroundAdvances in biodegradable and injectable hydrogels for biomedical applications
Li, Y., Yang, H. Y., & Lee, D. S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.008 · Cited by 261 · cited 1× · see citing works
“Sci. 2024 , 25 , x FOR PEER REVIEW 3 of 24 minimally invasive delivery method enables injectable hydrogels to be a promising tool in clinical practice [32].”
MethodAbdominal adhesions: Current and novel therapies
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“Biological coatings can be used to reduce the adhesion between biological tissues [154].”
BackgroundWang, Y., Yu, Y., Guo, J., Zhang, Z., Zhang, X., & Zhao, Y. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000151 · Cited by 247 · cited 2× · see citing works
“…adhesive performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug…”
BackgroundTissue adhesives: From research to clinical translation
Bal-Ozturk, A., Cecen, B., Avci-Adali, M., Topkaya, S. N., Alarcin, E., Yasayan, G., Li, Y.-C. E., Bulkurcuoglu, B., Akpek, A., Avci, H., et al. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101049 · Cited by 246 · see citing works
Pectin-based injectable biomaterials for bone tissue engineering
Munarin, F., Guerreiro, S. G., Grellier, M. A., Tanzi, M. C., Barbosa, M. A., Petrini, P., & Granja, P. L. (2011) · Biomacromolecules · doi:10.1021/bm101110x · Cited by 242 · cited 1× · see citing works
“It creates an advantageous microenvironment that fosters cell adhesion, proliferation, and differentiation, which further guides and accelerates the tissue regeneration process [134].”
BackgroundRecent advances of injectable hydrogels for drug delivery and tissue engineering applications
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Practical recombinant hybrid mussel bioadhesive fp-151
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“The yield of extraction of mussel adhesive proteins is extremely low [46]. adhesive hydrogels.”
BackgroundBioinspired double-dynamic-bond crosslinked bioadhesive enables post-wound closure care
Li, S., Chen, N., Li, X., Li, Y., Xie, Z., Ma, Z., Zhao, J., Hou, X., & Yuan, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000130 · Cited by 204 · cited 4× · see citing works
“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion…”
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“These desirable properties finally facilitated their application in bacteria-infected wound healing [108].”
BackgroundDefining the catechol-cation synergy for enhanced wet adhesion to mineral surfaces
Rapp, M. V., Maier, G. P., Dobbs, H. A., Higdon, N. J., Waite, J. H., Butler, A., & Israelachvili, J. N. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b03453 · Cited by 200 · cited 1× · see citing works
“Recent studies show that the synergistic effect of cation and catechol promoted wet adhesion [102,103].”
BackgroundFrom design to applications of stimuli-responsive hydrogel strain sensors
Zhang, D., Ren, B., Zhang, Y., Xu, L., Huang, Q., He, Y., Li, X., Wu, J., Yang, J., Chen, Q., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02692d · Cited by 199 · cited 1× · see citing works
“Stimuli-responsive hydrogels can respond to a variety of environmental stimuli [152,153] and, therefore, can be applied in the detection of some biological signals.”
BackgroundFathi, M., Alami-Milani, M., Geranmayeh, M. H., Barar, J., Erfan-Niya, H., & Omidi, Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.122 · Cited by 194 · cited 1× · see citing works
“In recent years, researchers have developed numerous injectable gels for drug delivery [145–147].”
BackgroundHua, Y., Xia, H., Jia, L., Zhao, J., Zhao, D., Yan, X., Zhang, Y., Tang, S., Zhou, G., Zhu, L., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg0628 · Cited by 191 · cited 1× · see citing works
“Unlike regular bone tissue, however, cartilage lacks blood vessels, cellular reproduction, and regenerative capacity [138].”
BackgroundFacile DNA immobilization on surfaces through a catecholamine polymer
Ham, H. O., Liu, Z., Lau, K. H. A., Lee, H., & Messersmith, P. B. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005001 · Cited by 189 · cited 1× · see citing works
“Even so, unprotected Therefore, commonly, catechol is protected before polymerization [47]. polymerizations of catechol-based monomers have been reported Even so, unprotected polymerizations of catechol-based monomers have been reported in recent years [56,57]. in recent years [56,57].”
Background<i>In situ</i> formation of injectable hydrogels for chronic wound healing
Gao, Y., Li, Z., Huang, J., Zhao, M., & Wu, J. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01074j · Cited by 189 · see citing works
Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis
Xu, J., Tam, M., Samaei, S., Lerouge, S., Barralet, J. E., Stevenson, M. M., & Cerruti, M. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.10.026 · Cited by 188 · cited 2× · see citing works
“…are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug delivery [20,21], cell…”
BackgroundRen, Y., Zhao, X., Liang, X., Ma, P. X., & Guo, B. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.07.130 · Cited by 188 · see citing works
Yang, W., Kang, X., Gao, X., Zhuang, Y., Fan, C., Shen, H., Chen, Y., & Dai, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202211340 · Cited by 188 · cited 1× · see citing works
“However, it is often criticized for its time-consuming operations and secondary tissue damage [115].”
BackgroundEmerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164 · see citing works
Yang, Y. P., He, G., Pan, Z., Zhang, K., Xian, Y., Zhu, Z., Hong, Y., Zhang, C., & Wu, D. (2024) · Advanced Materials · doi:10.1002/adma.202404811 · Cited by 153 · see citing works
Bone tissue engineering by gene delivery
KOFRON, M., & LAURENCIN, C. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.008 · Cited by 151 · cited 1× · see citing works
“However, there are still some limitations to these treatments, such as the risk of creating new defects at the donor site, potential immune rejection, and the pain associated with surgical procedures [131,132].”
BackgroundShan, M., Gong, C., Li, B., & Wu, G. (2017) · Polymer Chemistry · doi:10.1039/c7py00519a · Cited by 151 · cited 1× · see citing works
“At pH 9.0, mixing the two modified PEGs led to the fast formation of a PEG-based hydrogel by boron ester-based crosslinking (borate–catechol complexation) [69].”
BackgroundInfluentialPark, H., Jin, Y., Shin, J., Yang, K., Lee, C., Yang, H. S., & Cho, S. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.5b01670 · Cited by 142 · cited 2× · see citing works
“…biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc.…”
BackgroundMussel-inspired hydrogel tissue adhesives for wound closure
Rahimnejad, M., & Zhong, W. (2017) · RSC Adv. · doi:10.1039/c7ra06743g · Cited by 135 · see citing works
Stimuli‐Responsive Hydrogels for Antibacterial Applications
Hao, Z., Li, X., Zhang, R., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400513 · Cited by 135 · cited 1× · see citing works
“Stimuli-responsive hydrogels can respond to a variety of environmental stimuli [152,153] and, therefore, can be applied in the detection of some biological signals.”
BackgroundPainting blood vessels and atherosclerotic plaques with an adhesive drug depot
Kastrup, C. J., Nahrendorf, M., de Figueiredo, J. L., Lee, H., Kambhampati, S., Lee, T. J., Cho, S., Gorbatov, R., Iwamoto, Y., Dang, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217972110 · Cited by 129 · cited 2× · see citing works
“…applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug delivery [20,21], cell…”
BackgroundZhang, X., Chen, J., He, J., Bai, Y., & Zeng, H. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.10.023 · Cited by 129 · cited 2× · see citing works
“…performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug…”
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“Diabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS) [109,110].”
BackgroundRobust, self-healing hydrogels synthesised from catechol rich polymers
Yavvari, P. S., & Srivastava, A. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01307g · Cited by 126 · cited 1× · see citing works
“Due to the instability of the formed imine bond, the sodium borohydride (NaBH 4 )-mediated reductive amination reaction is usually necessary [49,50].”
BackgroundLee, J., Chang, K., Kim, S., Gite, V., Chung, H., & Sohn, D. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b01198 · Cited by 122 · see citing works
Yang, B., Ayyadurai, N., Yun, H., Choi, Y. S., Hwang, B. H., Huang, J., Lu, Q., Zeng, H., & Cha, H. J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201406099 · Cited by 121 · cited 1× · see citing works
“This strategy created mussel adhesive proteins with a high DOPA content [59], showing promise in the production of mussel-inspired macromolecules.”
BackgroundAn injectable and instant self-healing medical adhesive for wound sealing
Sun, F., Bu, Y., Chen, Y., Yang, F., Yu, J., & Wu, D. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c01022 · Cited by 117 · see citing works
Pan, X., Wang, Q., He, P., Liu, K., Ni, Y., Ouyang, X., Chen, L., Huang, L., Wang, H., & Tan, Y. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b00579 · Cited by 109 · cited 3× · see citing works
“…[61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
BackgroundWang, B., Liu, J., Niu, D., Wu, N., Yun, W., Wang, W., Zhang, K., Li, G., Yan, S., Xu, G., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c06058 · Cited by 109 · cited 3× · see citing works
“…are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion gel coatings…”
BackgroundInfluentialMussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications
Quan, W., Hu, Z., Liu, H., Ouyang, Q., Zhang, D., Li, S., Li, P., & Yang, Z. (2019) · Molecules · doi:10.3390/molecules24142586 · Cited by 107 · see citing works
Self-citationFu, M., Zhao, Y., Wang, Y., Li, Y., Wu, M., Liu, Q., Hou, Z., Lu, Z., Wu, K., & Guo, J. (2023) · Small · doi:10.1002/smll.202205489 · Cited by 107 · cited 1× · see citing works
“In vivo results show that the TE-CMBA hydrogels were able to modulate the inflammatory microenvironment, promote angiogenesis, enhance the production of the extracellular matrix (ECM), and improve re-epithelialization, showing effectiveness in the treatment of diabetic wounds [111].”
BackgroundA pH-induced self-healable shape memory hydrogel with metal-coordination cross-links
Lu, L., Tian, T., Wu, S., Xiang, T., & Zhou, S. (2019) · Polymer Chemistry · doi:10.1039/c9py00015a · Cited by 103 · cited 1× · see citing works
“Since these interactions are reversible, the obtained hydrogels usually show self-healing properties [81,82].”
BackgroundDeng, X., Huang, B., Wang, Q., Wu, W., Coates, P., Sefat, F., Lu, C., Zhang, W., & Zhang, X. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c06672 · Cited by 94 · see citing works
Chen, X., Wu, T., Bu, Y., Yan, H., & Lin, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147810 · Cited by 88 · cited 1× · see citing works
“Autologous and allogeneic bone grafts are the most frequently employed clinical techniques [129,130].”
BackgroundHu, S., Yang, Z., Zhai, Q., Li, D., Zhu, X., He, Q., Li, L., Cannon, R. D., Wang, H., Tang, H., et al. (2023) · Small · doi:10.1002/smll.202207437 · Cited by 87 · cited 1× · see citing works
“In addition, owing to the existence of the DOPA/Cu 2+ complex, PDPC hydrogels also exhibit antimicrobial and anti-inflammatory properties, showing great potential in promoting diabetic wound healing [122].”
BackgroundInjectable, self-healing chimeric catechol-Fe(III) hydrogel for localized combination cancer therapy
Yavvari, P. S., Pal, S., Kumar, S., Kar, A., Awasthi, A. K., Naaz, A., Srivastava, A., & Bajaj, A. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00741 · Cited by 85 · cited 1× · see citing works
“Since these interactions are reversible, the obtained hydrogels usually show self-healing properties [81,82].”
BackgroundWang, W., Jia, B., Xu, H., Li, Z., Qiao, L., Zhao, Y., Huang, H., Zhao, X., & Guo, B. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143362 · Cited by 85 · cited 1× · see citing works
“The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity [36,105–107].”
BackgroundYegappan, R., Selvaprithiviraj, V., Mohandas, A., & Jayakumar, R. (2019) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2019.01.035 · Cited by 84 · cited 2× · see citing works
“In vitro results indicate that human umbilical vein endothelial cells (HUVECs) treated with DMOG-loaded HA-Cys/PDA hydrogel showed an enhanced capillary tube formation, confirming its potential in tissue engineering [149].”
BackgroundTough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications
Ouyang, C., Yu, H., Wang, L., Ni, Z., Liu, X., Shen, D., Yang, J., Shi, K., & Wang, H. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.102982 · Cited by 82 · see citing works
Wu, D., Shi, X., Zhao, F., Chilengue, S. T. F., Deng, L., Dong, A., Kong, D., Wang, W., & Zhang, J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.06.033 · Cited by 81 · cited 1× · see citing works
“In vivo studies show that the NP-gel can effectively inhibit tumor recurrence and avoid severe toxicity to healthy organs [150].”
BackgroundChen, Y., Qiu, Y., Wang, Q., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125668 · Cited by 77 · cited 1× · see citing works
“Mussel-inspired composite hydrogels containing nanomaterials are an emerging material that has been widely used in drug delivery [148,149].”
BackgroundPang, Y., Wang, H., Yao, Y., Chen, D., Yang, R., Wang, Z., Yang, J., Li, Y., & Liu, W. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202303095 · Cited by 76 · cited 1× · see citing works
“Additionally, mussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability [85,86].”
BackgroundSun, A., Hu, D., He, X., Ji, X., Li, T., Wei, X., & Qian, Z. (2022) · NPG Asia Materials · doi:10.1038/s41427-022-00434-z · Cited by 74 · see citing works
Zhou, Y., Zhao, J., Sun, X., Li, S., Hou, X., Yuan, X., & Yuan, X. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.5b01550 · Cited by 72 · cited 2× · see citing works
“Tuning the ratio of catechol to the crosslinking agent or crosslinking hydrogels by other functional groups may be a good solution to this issue [70,100].”
BackgroundMethodInfluentialSelf-citationGong, C., Lu, C., Li, B., Shan, M., & Wu, G. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35931 · Cited by 72 · cited 3× · see citing works
“The curcumin-loaded PDAEA-Fe 3+ hydrogel showed a slow and sustained release profile in 4 weeks, suggesting the potential of PDAEA-Fe 3+ hydrogel in drug delivery [42].”
BackgroundInfluentialDopamine-based high-transparent hydrogel as bioadhesive for sutureless ocular tissue repair
Qian, Y., Xu, K., Shen, L., Dai, M., Zhao, Z., Zheng, Y., Wang, H., Xie, H., Wu, X., Xiao, D., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202300707 · Cited by 71 · cited 1× · see citing works
“For example, methacrylamide dopamine (DMA) can keep catechol stable, even in an oxidation environment [156].”
BackgroundLei, X., Zou, C., Hu, J., Fan, M., Jiang, Y., Xiong, M., Han, C., Zhang, X., Li, Y., Zhao, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202306289 · Cited by 70 · cited 1× · see citing works
“Employing materials capable of absorbing blood (or eliminating bodily fluids) and adhering to tissues is a promising therapeutic approach to treating uncontrolled bleeding [127].”
BackgroundImpact of bone marrow mesenchymal stem cell immunomodulation on the osteogenic effects of laponite
Li, T., Liu, Z. L., Xiao, M., Yang, Z. Z., Peng, M., Li, C. D., Zhou, X. J., & Wang, J. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0818-0 · Cited by 67 · cited 1× · see citing works
“In addition to nHA, laponite (Lap) [137] was also used with mussel-inspired injectable hydrogels for bone repair.”
MethodInjectable hydrogels as emerging drug-delivery platforms for tumor therapy
Cheng, Y., Zhang, H., Wei, H., & Yu, C.-Y. (2024) · Biomaterials Science · doi:10.1039/d3bm01840g · Cited by 65 · cited 1× · see citing works
“Hydrogels offer a versatile platform for the creation of drug-carrying systems that are responsive to specific stimuli [143].”
BackgroundHe, X. Y., Sun, A., Li, T., Qian, Y. J., Qian, H., Ling, Y. F., Zhang, L. H., Liu, Q. Y., Peng, T., & Qian, Z. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116692 · Cited by 64 · see citing works
Fang, W., Yang, L., Hong, L., & Hu, Q. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118428 · Cited by 61 · cited 4× · see citing works
“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion…”
BackgroundInfluentialHu, W., Zhang, Z., Lu, S., Zhang, T., Zhou, N., Ren, P., Wang, F., Yang, Y., & Ji, Z. (2018) · Biomaterials Science · doi:10.1039/c8bm00824h · Cited by 60 · cited 4× · see citing works
“…[61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
BackgroundInfluentialSwitching the adhesive state of catecholic hydrogels using phototitration
White, E. M., Seppala, J. E., Rushworth, P. M., Ritchie, B. W., Sharma, S., & Locklin, J. (2013) · Macromolecules · doi:10.1021/ma401594z · Cited by 58 · cited 3× · see citing works
“…regulation of polymerization conditions, such as polymerization time, monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57]. monomer concentration, and oxygen-free atmosphere, was found to be important for successful polymerization [57].”
BackgroundZhu, J., Zhong, K., Zong, Y., Wang, S., Yang, H., Li, Z., Tao, S., Sun, L., Yang, J., & Li, J. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.110347 · Cited by 58 · cited 1× · see citing works
“Considering that the marine mussel exhibits robust adhesion to wet rocks, some mussel-inspired adhesive hydrogels were designed and applied in the closure of wet wounds [101].”
BackgroundBioinspired super-strong aqueous synthetic tissue adhesives
Li, Q., Song, W., Li, J., Ma, C., Zhao, X., Jiao, J., Mrowczynski, O., Webb, B. S., Rizk, E. B., Lu, D., et al. (2022) · Matter · doi:10.1016/j.matt.2021.12.018 · Cited by 58 · see citing works
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“Their robust tissue adhesive properties, minimally invasive abilities, devisable self-healing capabilities, and tunable cell compatibility enable mussel-inspired injectable hydrogels to be applied in bone repair [135,136].”
BackgroundMahmoudi, C., Tahraoui Douma, N., Mahmoudi, H., Iurciuc (Tincu), C. E., & Popa, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147839 · Cited by 57 · see citing works
A comparative study on the bulk adhesive strength of the recombinant mussel adhesive protein fp-3
Yang, B., Kang, D. G., Seo, J. H., Choi, Y. S., & Cha, H. J. (2013) · Biofouling · doi:10.1080/08927014.2013.782541 · Cited by 51 · cited 1× · see citing works
“In this method, mushroom tyrosinase, which can convert tyrosine residues to DOPA, is used [58].”
MethodDopa-empowered schiff base forming alginate hydrogel glue for rapid hemostatic control
Song, C. K., Kim, M.-K., Lee, J., Davaa, E., Baskaran, R., & Yang, S.-G. (2019) · Macromolecular Research · doi:10.1007/s13233-019-7026-3 · Cited by 46 · see citing works
Enzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property
Kim, M. H., Lee, J. N., Lee, J., Lee, H., & Park, W. H. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00411 · Cited by 45 · see citing works
Ma, W., Yang, M., Wu, C., Wang, S., & Du, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126145 · Cited by 45 · cited 3× · see citing works
“…mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings…”
BackgroundInfluentialThe osteochondral dilemma: Review of current management and future trends
Ye, K., Di Bella, C., Myers, D. E., & Choong, P. F. M. (2014) · ANZ Journal of Surgery · doi:10.1111/ans.12108 · Cited by 44 · cited 1× · see citing works
“However, there are still some limitations to these treatments, such as the risk of creating new defects at the donor site, potential immune rejection, and the pain associated with surgical procedures [131,132].”
BackgroundLi, M., Schlaich, C., Willem Kulka, M., Donskyi, I. S., Schwerdtle, T., Unger, W. E. S., & Haag, R. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00534j · Cited by 44 · cited 2× · see citing works
“…glues exhibit desirable adhesive performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl…”
Man, Z., Sidi, L., Xubo, Y., Jin, Z., & Xin, H. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.09.100 · Cited by 44 · cited 3× · see citing works
“Interactions, including hydrogen bonding, π - π stacking, cation-π interactions, electrostatic forces, and hydrophobic e ff ects, are frequently employed to create self-healable hydrogel networks [3,51].”
BackgroundMethodSelf-citationHou, M., Wang, X., Yue, O., Zheng, M., Zhang, H., & Liu, X. (2022) · Biomaterials Advances · doi:10.1016/j.msec.2021.112556 · Cited by 42 · see citing works
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“Their robust tissue adhesive properties, minimally invasive abilities, devisable self-healing capabilities, and tunable cell compatibility enable mussel-inspired injectable hydrogels to be applied in bone repair [135,136].”
BackgroundKim, J. Y., Ryu, S. B., & Park, K. D. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.09.014 · Cited by 38 · see citing works
Mussel-inspired epoxy bioadhesive with enhanced interfacial interactions for wound repair
Du, D., Chen, X., Shi, C., Zhang, Z., Shi, D., Kaneko, D., Kaneko, T., & Hua, Z. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.09.054 · Cited by 38 · cited 2× · see citing works
“…adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl exible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. Int.”
BackgroundWei, C., Shi, W., Zhao, C., Yang, S., Zheng, J., Zhong, J., Zhao, T., Kong, S., Gong, X., & Liu, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202201799 · Cited by 38 · cited 1× · see citing works
“Injectable hydrogel-based tissue adhe-sives, with their shape adaptability and minimally invasive characteristics, have become promising alternatives for hemorrhage control [116].”
BackgroundChen, Y., Zhang, Y., Chang, L., Sun, W., Duan, W., & Qin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125644 · Cited by 35 · cited 1× · see citing works
“Therefore, the mussel-inspired adhesive hydrogels usually exhibit antioxidant properties [83,84].”
BackgroundMussel-inspired polymer-based coating technology for antifouling and antibacterial properties
Imbia, A. S., Ounkaew, A., Mao, X., Zeng, H., Liu, Y., & Narain, R. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c00326 · Cited by 35 · cited 2× · see citing works
“…glues exhibit desirable adhesive performance and are applied in numerous fields, including biomedical adhesives [14,15], antifouling coatings [16,17], flexible electronics [18,19], drug delivery [20,21], cell encapsulation and delivery [22,23], etc. 14,15], antifouling coatings [16,17], fl…”
BackgroundAn injectable, robust double network adhesive hydrogel for efficient, real-time hemostatic sealing
Zhang, W., Song, S., Huang, J., & Zhang, Z. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146244 · Cited by 34 · see citing works
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“Using these classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin (GT), and synthetic polymers, such as polyethylene glycol (PEG)-based polymers [45,47,51–55].”
BackgroundEffects of dopamine-containing curing agents on the water resistance of epoxy adhesives
Dai, F., Chen, F., Wang, T., Feng, S., Hu, C., Wang, X., & Zheng, Z. (2016) · Journal of Materials Science · doi:10.1007/s10853-016-9743-8 · Cited by 32 · see citing works
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“This gelation process was mainly due to the oxidation-induced coupling of the catechol groups [66].”
BackgroundWu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111705 · Cited by 28 · cited 1× · see citing works
“It can serve as an osteoimmune regulator to promote bone regeneration [40].”
BackgroundSelf-citationLiu, Q., Yang, L., Wang, L., Li, Z., Yu, Y., Zheng, Y., Lian, D., Li, X., Chen, H., Mei, L., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125064 · Cited by 28 · see citing works
Self-citationZhu, S., Dou, W., Zeng, X., Chen, X., Gao, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105249 · Cited by 28 · cited 1× · see citing works
“Diabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS) [109,110].”
BackgroundSelf-citationLiu, J., Song, J., Zeng, L., & Hu, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147994 · Cited by 28 · cited 1× · see citing works
“These works reveal that a noncanonical amino acid, namely, 3,4-dihydroxyphenylalanine (DOPA) exists in the mussel adhesive proteins [6,7].”
BackgroundMussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing
Cui, G., Guo, X., Su, P., Zhang, T., Guan, J., & Wang, C. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1154788 · Cited by 26 · cited 3× · see citing works
“Nanomaterials, with their large surface area, are capable of generating nanoscale effects that significantly enhance blood absorption and cell adhesion [119].”
BackgroundInfluentialXu, L., Jiao, G., Huang, Y., Ren, P., Liang, M., Wei, D., & Zhang, T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128288 · Cited by 24 · cited 1× · see citing works
“In hemostatic experiments, the hydrogel was found to be capable of reducing hemostasis time and lowering the loss of blood in a liver-bleeding mouse model [126].”
MethodSenarath-Yapa, K., Li, S., Walmsley, G. G., Zielins, E., Paik, K., Britto, J. A., Grigoriadis, A. E., Wan, D. C., Liu, K. J., Longaker, M. T., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0527 · Cited by 22 · see citing works
Self-citationAdvances of mussel-inspired hydrogels for Bone/Cartilage regeneration
Li, H., Wang, J., Yang, G., Pei, X., & Zhang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150560 · Cited by 22 · see citing works
Li, S., Dou, W., Ji, W., Li, X., Chen, N., Ji, Y., Zeng, X., Sun, P., Li, Y., Лю, Ч., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.06.030 · Cited by 22 · cited 1× · see citing works
“With the development of adhesive hydrogels, in addition to mussel-inspired adhesive hydrogels, many other types of adhesive hydrogels have been reported for biomedical applications [78–80].”
BackgroundSelf-citationDong, Q., Liang, X., Chen, F., Ke, M., Yang, X., Ai, J., Cheng, Q., Zhou, Y., & Chen, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.051 · Cited by 21 · cited 2× · see citing works
“In vivo results show that the shape memory sponge exhibited remarkable hemostatic performance in a rat liver prick hemorrhage model and other deep, narrow, and noncompressible hemorrhage models [112].”
BackgroundMussel-inspired hydrogel composite with multi-stimuli responsive behavior
Yan, Y., Rong, L., Ge, J., Tiu, B. D. B., Cao, P., & Advincula, R. C. (2019) · Macromolecular Materials and Engineering · doi:10.1002/mame.201800720 · Cited by 18 · cited 2× · see citing works
“This method utilizes the Schi ff base reactions between the aldehyde polysaccharides and 3,4-dihydroxyphenethylamine [48] or between 3,4-dihydroxybenzaldehyde and amino-containing polysaccharides [49].”
BackgroundMethodZeng, Z., Liu, D., Li, D., et al. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111782 · Cited by 18 · cited 1× · see citing works
“…coordination/oxidation-induced catechol-based crosslinking [74] Schiff base reaction/catechol-based Michael addition and Schiff base reaction [75] Fenton reaction and Dopa–Fe 3+ complexation [76] Michael addition and catechol–Fe coordination/oxidation-induced catechol-based crosslinking [77] 3.”
BackgroundEnvironment-dependent adhesive behaviors of mussel-inspired coordinate-crosslinked bioadhesives
Li, S., Chen, N., Li, Y., Zhao, J., Hou, X., & Yuan, X. (2020) · Macromolecular Materials and Engineering · doi:10.1002/mame.201900620 · Cited by 17 · cited 1× · see citing works
“Tuning the ratio of catechol to the crosslinking agent or crosslinking hydrogels by other functional groups may be a good solution to this issue [70,100].”
BackgroundSelf-citationInjectable Dopamine–Polysaccharide In Situ Composite Hydrogels with Enhanced Adhesiveness
Chen, X., Du, D., Zhang, Z., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00866 · Cited by 17 · cited 1× · see citing works
“…base reaction and catechol–catechol adducts [73] Schiff base reaction and catechol–Fe coordination/oxidation-induced catechol-based crosslinking [74] Schiff base reaction/catechol-based Michael addition and Schiff base reaction [75] Fenton reaction and Dopa–Fe 3+ complexation [76] Michael…”
BackgroundLi, S., Chen, N., Li, Y., Li, X., Zhan, Q., Ban, J., Zhao, J., Hou, X., & Yuan, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.257 · Cited by 16 · see citing works
Self-citationDevelopment of an injectable dopamine-conjugated poly(organophophazene) hydrogel for hemostasis
Kim, Y., Kim, C., Park, M., & Song, S. (2016) · Bulletin of the Korean Chemical Society · doi:10.1002/bkcs.10686 · Cited by 13 · cited 1× · see citing works
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
BackgroundZhao, Y., Lu, W., Shen, S., & Wei, L. (2021) · Cellulose · doi:10.1007/s10570-021-04258-y · Cited by 11 · cited 3× · see citing works
“…[61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelec-trodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
BackgroundMethodMussel-inspired hydrogels for tissue healing
Geng, H., Cui, J., & Hao, J. (2020) · Acta Chimica Sinica · doi:10.6023/a19080301 · Cited by 10 · cited 1× · see citing works
“Therefore, mussel-inspired nanocomposite hydrogels have been widely studied and emerged as an essential type in mussel-inspired hemostatic materials [123–125].”
BackgroundLi, S., Dou, W., Zhu, S., Zeng, X., Ji, W., Li, X., Chen, N., Li, Y., Liu, C., Fan, H., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133655 · Cited by 6 · see citing works
Self-citationJiang, Z., Yang, H., Xu, Y., Zou, H., Wang, Y., Wang, B., Yu, X., Su, G., & Zheng, Y. (2024) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2023.12.001 · Cited by 3 · see citing works
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Bioinspired Nanoplatforms: Polydopamine and Exosomes for Targeted Antimicrobial Therapy
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Engineering Adhesive Hydrogels for Hemostasis and Vascular Repair
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“In particular, previously reported mussel‐inspired adhesive hydrogels generally endure weak mechanical strength and poor deformability, which impede their ability to meet the toughness and roughness requirements for tissue engineering [21, 22].”
Hydrogel-integrated multimodal physiological and modulation systems
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Organogels: Mechanistic insights, design strategies, and translational applications
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Insights on the Flotation Separation of Hematite from Quartz with a 4-Tert-butyl-catechol Collector
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“In effect, these hydrogels improve material retention and integration after implantation [49,81].”
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“DOPA groups contribute to strong interfacial adhesion through hydrogen bonding, metal chelation, and π – π interactions with tissue surfaces [ 33 , 34 ].”
Poly(L-Tyrosine)-Containing Dehydropeptides: Hydrogels vs. Bioadhesives
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“This outcome mimics aquatic species, especially mussels ( Mytilus spp.) [47,48], whose remarkable wet adhesion properties have inspired an entire generation of wet-resistant adhesives, due to the presence of foot proteins (MFPs) enriched with L-3,4-dihydroxyphenylalanine (L-DOPA), tyrosine, and…”
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Nature-Inspired Solutions: Biomimetic Materials and Adaptive Devices for Precision Urinary Oncology
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“Recent reviews further indicate that catechol-based materials, especially polydopamine and injectable adhesive hydrogels, have become a major direction in biomedical adhesion and drug delivery research [45,46].”
InfluentialCondensate-based sequestration enables high-efficiency synthesis of mussel foot protein Mcofp-3
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Biopolymer-based bioadhesives with a focus on clinical translations and multifunctional bioadhesives
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Self-citationRapidly Photocured Catechol-Thiol Adhesive for Wet and Submerged Biological Interfaces
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Synergistic Hydrogels Enabled by Dual-Regulatory Mussel Foot Protein for Advancing Wound Healing
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- Authors
- Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S.
- Affiliations
- Yantai University (CN)
- Corresponding author
- Liu, Hongliang
- Li, Sidi
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2024-08-22
- Volume
- 25
- Issue
- 16
- Pages
- 9100
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC11354882
- OpenAlex
- W4401894455
- Semantic Scholar
- 3ea54ad85d1321cc68a166a17083c8c5753adbc7
- Cited by
- 52
- References
- 156
- Citations by year
- 2026: 30 · 2025: 21 · 2024: 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541, AMGM2024F07)
- Natural Science Foundation of Shandong Province (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541, AMGM2024F07)
- Taishan Young Scholar Program (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541, AMGM2024F07)
- Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541, AMGM2024F07)
- Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541, AMGM2024F07)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- mussel-inspired materials, injectable hydrogel, adhesive hydrogels, catechol groups, self-healing hydrogels, antimicrobial hydrogels, antioxidant hydrogel, crosslinking methods, tissue adhesion, biomimetic materials
- MeSH terms
- Adhesives, Animals, Biocompatible Materials, Humans, Injections, Tissue Adhesives, Hydrogels, Biomimetic Materials, Bivalvia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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