Tailoring tumor cell golgi apparatus-targeting self-assembled peptide for effective immunotherapy via reshaping MIF-mediated immunosuppressive network
Open accessAbstract
The immunosuppressive network formed by the enhanced crosstalk between tumor cells and various types of immune cells may ultimately lead to the formation of tumor immunosuppressive microenvironment (TIME). The Golgi apparatus (GA) of tumor cells is a key organelle in the formation of a tumor immunosuppressive network. However, there are no studies to show whether interfering with the GA of tumor cells can reshape the immunosuppressive network to enhance the effectiveness of immunotherapy. Therefore, the tumor cell GA‐targeting self‐assembled peptide (NF‐1) is tailored, and confirmed that NF‐1 treatment can achieve an effective immunotherapy and found that tumor cell‐derived GA‐dependent migration inhibitory factor (MIF) mediates the formation of immunosuppressive network in breast cancer (BRCA) through multi‐omics analysis, in vivo, and in vitro experiments. NF‐1 treatment‐induced MIF reduction can reshape the immunosuppressive network and convert a “cold” tumor into a “hot” tumor, thus enabling immunotherapy in BRCA and enhancing the ICB efficacy in colon adenocarcinoma (COAD). This study presents a general strategy for interfering with tumor GA for effective immunotherapy in BRCA, COAD, and other cancers characterized by a “cold” immune microenvironment.
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The Golgi apparatus exerts substantial influence on the tumor immune microenvironment by controlling cytokine secretion, antigen presentation, and expression of immune checkpoint molecules.
“The GA also exerts substantial influence on the tumor immune microenvironment by controlling cytokine secretion, antigen presentation, and the expression of immune checkpoint molecules.”
From Construction and validation of golgi apparatus-related genes as predictors of the immune microenvironment and prognosis in colorectal cancer (2026) · cites this paper as [13]
The Introduction (page unavailable) describes the Golgi apparatus as a contributor to tumor-cell secretion and immune-cell crosstalk, including the production of immunosuppressive cytokines. The Results and Discussion (page unavailable) report an association between Golgi-dependent MIF and immune regulation, but do not establish that the Golgi controls antigen presentation or immune-checkpoint expression; the reported checkpoint finding is a correlation with MIF expression. (LLM, conf=0.86)
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Cites
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Jiang, P., Gu, S., Pan, D., Fu, J., Sahu, A., Hu, X., Li, Z., Traugh, N., Bu, X., Li, B., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0136-1 · Cited by 5,179 · see citing works
Self-citationThe evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059 · see citing works
Characterization of a cis-Golgi matrix protein, GM130.
Nakamura, N., Rabouille, C., Watson, R., Nilsson, T., Hui, N., Slusarewicz, P., Kreis, T. E., & Warren, W. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1715 · Cited by 806 · see citing works
Synchronization of secretory protein traffic in populations of cells
Boncompain, G., Divoux, S., Gareil, N., de Forges, H., Lescure, A., Latreche, L., Mercanti, V., Jollivet, F., Raposo, G., & Perez, F. (2012) · Nature Methods · doi:10.1038/nmeth.1928 · Cited by 598 · see citing works
Temming, K., Schiffelers, R. M., Molema, G., & Kok, R. J. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.10.002 · Cited by 467 · see citing works
Beyond immune checkpoint blockade: emerging immunological strategies
Kubli, S. P., Berger, T., Araújo, D. V., Siu, L. L., & Mak, T. W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00155-y · Cited by 460 · see citing works
Furin‐mediated protein processing in infectious diseases and cancer
Braun, E., & Sauter, D. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1073 · Cited by 345 · see citing works
Yuan, Y., Zhang, J., Qi, X., Li, S., Liu, G., Siddhanta, S., Barman, I., Song, X., McMahon, M. T., & Bulte, J. W. M. (2019) · Nature Materials · doi:10.1038/s41563-019-0503-4 · Cited by 250 · see citing works
Cheng, D., Zhang, X., Gao, Y., Ji, L., Hou, D., Wang, Z., Xu, W., Qiao, Z., & Wang, H. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b07727 · Cited by 241 · see citing works
Yang, J., Griffin, A. S., Qiang, Z., & Ren, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01243-0 · Cited by 211 · see citing works
Sapperstein, S. K., Walter, D. M., Grosvenor, A. R., Heuser, J. E., & Waters, M. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.522 · Cited by 198 · see citing works
Li, H., Zhang, P., Luo, J., Hu, D., Huang, Y., Zhang, Z., Fu, Y. S., & Gong, T. (2019) · ACS Nano · doi:10.1021/acsnano.9b04166 · Cited by 163 · see citing works
Beyond the Barrier: Unraveling the Mechanisms of Immunotherapy Resistance
Bell, H. N., & Zou, W. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-024752 · Cited by 133 · see citing works
Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer
Li, Y., Chen, Z.-K., Duan, X., Zhang, H., Xiao, B.-L., Wang, K.-M., & Chen, G. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00856-3 · Cited by 112 · see citing works
Enzyme-Responsive Peptide Thioesters for Targeting Golgi Apparatus
Tan, W., Zhang, Q., Quiñones-Frías, M. C., Hsu, A. Y.-H., Zhang, Y., Rodal, A. A., Hong, P., Luo, H. R., & Xu, B. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02238 · Cited by 104 · see citing works
Ye, H., Wang, K., Zhao, J., Qi, L., Wang, M., Sun, B., Shen, Y., Liu, H., Pané, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01733 · Cited by 75 · see citing works
Potential therapies and diagnosis based on Golgi-targeted nano drug delivery systems
Zhang, M., Xu, N., Xu, W., Ling, G., & Zhang, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105861 · Cited by 54 · see citing works
Sánchez‐León, E., Bowman, B. J., Seidel, C., Fischer, R., Novick, P., & Riquelme, M. (2014) · Molecular Microbiology · doi:10.1111/mmi.12878 · Cited by 54 · see citing works
A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin
Hu, X., Hai, Z., Wu, C., Zhan, W., & Liang, G. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04186 · Cited by 52 · see citing works
Radulescu, A. E., Mukherjee, S., & Shields, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209460 · Cited by 51 · see citing works
Li, H., Deng, C., Tan, Y., Dong, J., Zhao, Y., Wang, X., Yang, X., Luo, J., Gao, H., Huang, Y., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.014 · Cited by 51 · see citing works
Li, Y., Zhang, T., Zhang, J., Liu, Q., Jia, Q., Chen, W., Tang, Q., Xiong, Y., Xia, Y., Xu, Y., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122232 · Cited by 50 · see citing works
The epigenetic modification during the induction of Foxp3 with sodium butyrate
Cao, T., Zhang, X., Chen, D., Zhang, P., Li, Q., & Muhammad, A. (2018) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2018.1480631 · Cited by 36 · see citing works
Li, J., & Stanger, B. Z. (2019) · Science · doi:10.1126/science.aau9861 · Cited by 34 · see citing works
Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells
Sugita, S., Kawazoe, Y., Imai, A., Usui, Y., Iwakura, Y., Isoda, K., Ito, M., & Mochizuki, M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11483 · Cited by 29 · see citing works
Oberholtzer, N., Chakraborty, P., Kassir, M. F., Dressman, J., Das, S., Mills, S., Comte-Walters, S., Gooz, M., Choi, S., Parikh, R. Y., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp1152 · Cited by 24 · see citing works
Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5
Linders, P. T. A., Gerretsen, E. C. F., Ashikov, A., Vals, M., de Boer, R., Revelo, N. H., Arts, R., Baerenfaenger, M., Zijlstra, F., Huijben, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26534-y · Cited by 23 · see citing works
Choi, W., Kang, S., & Kim, J. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01408-z · Cited by 23 · see citing works
Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis
Choi, J. E., MacDonald, C. R., Gandhi, N. S., Das, G. M., Repasky, E. A., & Mohammadpour, H. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101389 · Cited by 22 · see citing works
Wang, Y., Xiong, L., Dong, Z., Ran, K., Bai, W., Mo, Z., Huang, K., Ye, Y., Yuan, T., Yin, S., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03416 · Cited by 20 · see citing works
Self-citationMillarte, V., Boncompain, G., Tillmann, K. D., Perez, F., Sztul, E. S., & Farhan, H. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-03-0178 · Cited by 19 · see citing works
Sen, P., Kan, C. F. K., Singh, A. B., Rius, M., Kraemer, F. B., Sztul, E. S., & Liu, J. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103926 · Cited by 19 · see citing works
Self-citationCho, H., Huh, K. M., Shim, M. S., Cho, Y., Lee, J. Y., Lee, H. S., Kwon, Y. J., & Kang, H. C. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115386 · Cited by 18 · see citing works
Li, X. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i46.8619 · Cited by 15 · see citing works
Self-citationGolgi apparatus targeted therapy in cancer: Are we there yet?
Lee, Z. Y., Lee, W. H., Lim, J. S., Ali, A. A. A., Loo, J. S. E., Wibowo, A., Mohammat, M. F., & Foo, J. B. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122868 · Cited by 15 · see citing works
Chen, T.-T., Lin, Y., Zhang, S., Liu, S., Song, L., Zhong, W., Luo, Z., & Han, A. (2022) · Science Advances · doi:10.1126/sciadv.add7945 · Cited by 15 · see citing works
Ge, X., Cao, Y., Zhu, X., Yuan, B., He, L., Wu, A., & Li, J. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300265 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 24
- [1]S. P. Kubli, T. Berger, D. V. Araujo, L. L. Siu, T. W. Mak, Nat. Rev. Drug. Discov. 2021, 20, 899. 33686237
- [2]H. N. Bell, W. Zou, Annu. Rev. Immunol. 2024, 42, 521. 38382538 PMC11213679
- [3]J. Li, B. Z. Stanger, Science 2019, 363, 1038. 30846584
- [4]a) K. E. de Visser, J. A. Joyce, Cancer Cell 2023, 41, 374; 36917948 b) Y. Li, Z. K. Chen, X. Duan, H. J. Zhang, B. L. Xiao, K. M. Wang, G. Chen, Exp. Mol. Med. 2022, 54, 1379. 36117219 PMC9534887
- [5]J. Yang, A. Griffin, Z. Qiang, J. Ren, Signal. Transduct. Target. Ther. 2022, 7, 379. 36402753 PMC9675787
- [6]W. Choi, S. Kang, J. Kim, Arch. Pharm. Res. 2022, 45, 671. 36178581
- [7]Z. Y. Lee, W. H. Lee, J. S. Lim, A. A. A. Ali, J. S. E. Loo, A. Wibowo, M. F. Mohammat, J. B. Foo, Life. Sci. 2024, 352, 122868. 38936604
- [8]a) R. Bajaj, A. N. Warner, J. F. Fradette, D. L. Gibbons, Cells 2022, 11; 35563790 PMC9102947 b) X. Tan, P. Banerjee, L. Shi, G. Y. Xiao, B. L. Rodriguez, C. L. Grzeskowiak, X. Liu, J. Yu, D. L. Gibbons, W. K. Russell, C. J. Creighton, J. M. Kurie, Sci. Adv. 2021, 7. PMC8213221 34144984
- [9]N. Oberholtzer, P. Chakraborty, M. F. Kassir, J. Dressman, S. Das, S. Mills, S. Comte‐Walters, M. Gooz, S. Choi, R. Y. Parikh, Z. Hedley, S. Vaena, R. DeMass, G. Scurti, M. Romeo, V. K. Gangaraju, S. Berto, E. Hill, L. E. Ball, A. S. Mehta, E. N. Maldonado, M. I. Nishimura, B. Ogretmen, S. Mehrotra, Sci. Adv. 2024, 10, eadp1152. 39546607 PMC11566994
- [10]a) H. Li, C. Deng, Y. Tan, J. Dong, Y. Zhao, X. Wang, X. Yang, J. Luo, H. Gao, Y. Huang, Z. R. Zhang, T. Gong, Acta Biomater. 2022, 146, 357; 35577045 b) H. Ye, K. Wang, J. Zhao, Q. Lu, M. Wang, B. Sun, Y. Shen, H. Liu, S. Pané, X. Z. Chen, Z. He, J. Sun, ACS Nano 2023, 17, 10637. 37213184
- [11]a) H. Cho, K. M. Huh, M. S. Shim, Y. Y. Cho, J. Y. Lee, H. S. Lee, Y. J. Kwon, H. C. Kang, Adv. Drug Delivery Rev. 2024, 212, 115386; 38971180 b) M. Zhang, N. Xu, W. Xu, G. Ling, P. Zhang, Pharmacol. Res. 2022, 175, 105861. 34464677
- [12]a) Y. Li, T. Zhang, J. Zhang, Q. Liu, Q. Jia, W. Chen, Q. Tang, Y. Xiong, Y. Xia, Y. Xu, L. Mo, Y. Huang, J. He, Biomaterials 2023, 301, 122232; 37418856 b) H. Li, P. Zhang, J. Luo, D. Hu, Y. Huang, Z. R. Zhang, Y. Fu, T. Gong, ACS Nano 2019, 13, 9386; 31375027 c) Y. Wang, L. Xiong, Z. Dong, K. Ran, W. Bai, Z. Mo, K. Huang, Y. Ye, Y. Tao, S. Yin, M. Li, Q. He, ACS Appl. Mater. Interfaces 2023, 15, 28941. 37290012
- [13]a) W. Tan, Q. Zhang, M. C. Quiñones‐Frías, A. Y. Hsu, Y. Zhang, A. Rodal, P. Hong, H. R. Luo, B. Xu, J. Am. Chem. Soc. 2022, 144, 6709; 35404599 PMC9069992 b) X. Ge, Y. Cao, X. Zhu, B. Yuan, L. He, A. Wu, J. Li, Adv. Healthc. Mater. 2023, 12, e2300265. 37306309
- [14]a) E. Braun, D. Sauter, Clin. Transl. Immunol. 2019, 8, e1073; PMC6682551 31406574 b) X. Hu, Z. Hai, C. Wu, W. Zhan, G. Liang, Anal. Chem. 2021, 93, 1636. 33381969
- [15]K. Temming, R. M. Schiffelers, G. Molema, R. J. Kok, Drug Resist. Updat. 2005, 8, 381. 16309948
- [16]Y. Yuan, J. Zhang, X. Qi, S. Li, G. Liu, S. Siddhanta, I. Barman, X. Song, M. T. McMahon, J. W. M. Bulte, Nat. Mater. 2019, 18, 1376. 31636420 PMC6872935
- [17]D. B. Cheng, X. H. Zhang, Y. J. Gao, L. Ji, D. Hou, Z. Wang, W. Xu, Z. Y. Qiao, H. Wang, J. Am. Chem. Soc. 2019, 141, 7235. 31010287
- [18]N. Nakamura, C. Rabouille, R. Watson, T. Nilsson, N. Hui, P. Slusarewicz, T. E. Kreis, G. Warren, J. Cell. Biol. 1995, 131, 1715. 8557739 PMC2120691
- [19]G. Boncompain, S. Divoux, N. Gareil, H. de Forges, A. Lescure, L. Latreche, V. Mercanti, F. Jollivet, G. Raposo, F. Perez, Nat. Methods 2012, 9, 493. 22406856
- [20]P. T. A. Linders, E. C. F. Gerretsen, A. Ashikov, M. A. Vals, R. de Boer, N. H. Revelo, R. Arts, M. Baerenfaenger, F. Zijlstra, K. Huijben, K. Raymond, K. Muru, O. Fjodorova, S. Pajusalu, K. Õunap, M. Ter Beest, D. Lefeber, G. van den Bogaart, Nat. Commun. 2021, 12, 6227. 34711829 PMC8553859
- [21]S. K. Sapperstein, D. M. Walter, A. R. Grosvenor, J. E. Heuser, M. G. Waters, Proc. Natl. Acad. Sci. USA 1995, 92, 522. 7831323 PMC42773
- [22]a) T. T. Chen, Y. Lin, S. Zhang, S. Liu, L. Song, W. Zhong, Z. Q. Luo, A. Han, Sci. Adv. 2022, 8, eadd7945; 36525490 PMC9757750 b) S. M. Camus, M. D. Camus, C. Figueras‐Novoa, G. Boncompain, L. A. Sadacca, C. Esk, A. Bigot, G. W. Gould, D. Kioumourtzoglou, F. Perez, N. J. Bryant, S. Mukherjee, F. M. Brodsky, J. Cell. Biol. 2020, 219; PMC7039200 31863584 c) E. Sánchez‐León, B. Bowman, C. Seidel, R. Fischer, P. Novick, M. Riquelme, Mol. Microbiol. 2015, 95, 472; 25425138 d) P. Sen, C. F. K. Kan, A. B. Singh, M. Rius, F. B. Kraemer, E. Sztul, J. Liu, J. Proteomics 2020, 229, 103926; 32736139 e) V. Millarte, G. Boncompain, K. Tillmann, F. Perez, E. Sztul, H. Farhan, Mol. Biol. Cell 2015, 26, 2263; 25904324 PMC4462944 f) A. E. Radulescu, S. Mukherjee, D. Shields, J. Biol. Chem. 2011, 286, 21915; 21536679 PMC3122246 g) X. J. Li, Y. Luo, Y. F. Yi, World J. Gastroenterol. 2013, 19, 8619. 24379579 PMC3870507
- [23]P. Jiang, S. Gu, D. Pan, J. Fu, A. Sahu, X. Hu, Z. Li, N. Traugh, X. Bu, B. Li, J. Liu, G. J. Freeman, M. A. Brown, K. W. Wucherpfennig, X. S. Liu, Nat. Med. 2018, 24, 1550. 30127393 PMC6487502
- [24]a) T. Cao, X. Zhang, D. Chen, P. Zhang, Q. Li, A. Muhammad, Immunopharmacol. Immunotoxicol. 2018, 40, 309; 30003817 b) S. Flaherty, J. M. Reynolds, J. Vis. Exp. 2015; PMC4541570 25938923 c) S. Sugita, Y. Kawazoe, A. Imai, Y. Usui, Y. Iwakura, K. Isoda, M. Ito, M. Mochizuki, Invest. Ophthalmol. Visual Sci. 2013, 54, 3240; 23532521 d) P. J. Murray, J. E. Allen, S. K. Biswas, E. A. Fisher, D. W. Gilroy, S. Goerdt, S. Gordon, J. A. Hamilton, L. B. Ivashkiv, T. Lawrence, M. Locati, A. Mantovani, F. O. Martinez, J. L. Mege, D. M. Mosser, G. Natoli, J. P. Saeij, J. L. Schultze, K. A. Shirey, A. Sica, J. Suttles, I. Udalova, J. A. van Ginderachter, S. N. Vogel, T. A. Wynn, Immunity 2014, 41, 14; 25035950 PMC4123412 e) J. E. Choi, C. R. MacDonald, N. Gandhi, G. Das, E. A. Repasky, H. Mohammadpour, STAR Protoc 2022, 3, 101389. 35600927 PMC9120228
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Wang, L., Shen, G., Xie, G., Li, Z., Ma, X., Li, M., Liu, Z., Wang, Y., Lv, Z., Fang, Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202509930 · Cited by 3 · see citing works
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Zhang, H., Wang, H., Wang, H., Liu, T., Mu, W., Shi, X., Weng, L., & Chen, X. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124314 · Cited by 1 · see citing works
Meng, Y., Zhang, Y., Yu, W., Xing, D., & Wang, C. (2025) · Materials Today Advances · doi:10.1016/j.mtadv.2025.100606
Self-citationZhang, K., Huang, C., Zhou, J., Fan, K., Ruan, M., & Xiao, Y. (2025) · Mediators of Inflammation · doi:10.1155/mi/3705788
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- Authors
- Li, X., Wang, C., Liu, J., Deng, G., Deng, Y., Hu, F., Wang, Y., & Zhou, D.
- Affiliations
- Southern Medical University (CN)
- Zhujiang Hospital (CN)
- Corresponding author
- Zhou, Dongfang
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2025-02-05
- Volume
- 12
- Issue
- 12
- Pages
- e2415133-e2415133
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC11948030
- OpenAlex
- W4407159002
- Cited by
- 8
- References
- 38
- Citations by year
- 2026: 3 · 2025: 5
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Advanced Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (22275081, 82372117)
- National Key Research and Development Program of China (2021YFC2400600/2021YFC2400602)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- Golgi apparatus targeting, self-assembling peptides, immunosuppressive tumor microenvironment, macrophage migration inhibitory factor, breast cancer, colon adenocarcinoma, cold tumor to hot tumor conversion, immune checkpoint blockade, tumor-immune cell crosstalk, cancer immunotherapy
- MeSH terms
- Animals, Breast Neoplasms, Colonic Neoplasms, Disease Models, Animal, Female, Golgi Apparatus, Humans, Immunotherapy, Macrophage Migration-Inhibitory Factors, Peptides, Intramolecular Oxidoreductases, Cell Line, Tumor, Mice, Tumor Microenvironment
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