CoChat
Sign Up
Cited by 62Reproductive System and PregnancyBarrier Structure and Function StudiesPregnancy and preeclampsia studies

The ultrastructure of the rat primary decidual zone

Parr, Margaret B., Tung, H. N., Parr, Earl L.·1986·American Journal of Anatomy
DOI 10.1002/aja.1001760405
Open this paper in CoChat — free account

Abstract

The rat primary decidual zone (PDZ) is a transitory, avascular region of transformed fibroblasts surrounding the implanting embryo. Tracer studies have indicated that the PDZ is selectively permeable to macromolecules, permeability decreasing with increasing molecular weight of the tracer. To clarify the morphological basis of the permeability barrier, we have studied the ultrastructure of the PDZ with particular emphasis on the intercellular features and cellular junctions. The cells of the PDZ were large and tightly packed; their apposed membranes showed extensive interdigitations in some regions, but elsewhere they were relatively straight. Tight junctions, gap junctions, and desmosomelike junctions were observed between decidual cells. The tight junctions usually consisted of one or two points of membrane fusion, and they were oriented both parallel and perpendicular to the long axis of the PDZ. These junctions were frequently associated with gap junctions. Scattered pockets of dilated extracellular space between decidual cells contained collagen fibrils and an amorphous, dense material. These extracellular components were also sequestered by the decidual cells in deep invaginations of the cell surface that were continuous with the extracellular space. Decidual cells also exhibited flangelike processes that penetrated the basal laminae of the adjacent epithelium and capillary endothelium. Our present observations indicate that decidual cells are connected by tight junctions, and a previous study demonstrated that macromolecules up to 40 kDa readily cross the PDZ; hence, the tight junctions appear to be discontinuous. We suggest that the structures restricting the movement of large macromolecules (66 kDa and larger) across the PDZ from blood vessels to the embryo may include discontinuous tight junctions, membrane interdigitations, and amorphous intercellular material.

Integrity signals

Registry

Crossref · 10.1002/aja.1001760405

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • It is likely that in rodents embryogenesis and early placental development take place in a low oxygen environment, as in the human, because at E6 the antimesometrial decidual cells form an avascular zone around the conceptus, separating it from the maternal blood.

    “It is likely that in rodents embryogenesis and early placental development take place in a low oxygen environment, as in the human, for at E6 the antimesometrial decidual cells form an avascular zone around the conceptus, separating it from the maternal blood (430).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [430]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Parr, M. B., Tung, H. N., & Parr, E. L.
Affiliations
Southern Illinois University Carbondale (US)
Corresponding author
Parr, Margaret B.
Venue
American Journal of Anatomy
Publisher
Wiley
Published
1986-08
Volume
176
Issue
4
Pages
423-436
ISSN
  • 0002-9106 (ISSN-L)
  • 1553-0795
DOI
10.1002/aja.1001760405
OpenAlex
W2060061920
Cited by
62
References
34
Citations by year
2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6761 d)
Locations
  • American Journal of Anatomy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-17480)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
decidual cells, tight junctions, gap junctions, desmosome-like junctions, collagen fibrils, invagination, basement membrane, embryo implantation, ultrastructure, rats
MeSH terms
Animals, Decidua, Female, Microscopy, Electron, Pregnancy, Rats, Inbred Strains, Time Factors, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review