Genetic modifiers of sickle cell disease

Mortality in sickle cell disease. Life expectancy and risk factors for early death

Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., & Klug, P. P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406093302303 · Cited by 3,320 · see citing works

Epigenetic modifications and human disease

Portela, A., & Esteller, M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1685 · Cited by 2,843 · see citing works

Environmental epigenomics and disease susceptibility

Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia

Charache, S., Terrin, M. L., Moore, R. D., Dover, G. J., Barton, F. B., Eckert, S. V., McMahon, R. P., & Bonds, D. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322001 · Cited by 2,340 · see citing works

Pain in Sickle Cell Disease: Rates and Risk Factors

Platt, O. S., Thorington, B. D., Brambilla, D. J., Milner, P. F., Rosse, W. F., Vichinsky, E., & Kinney, T. R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107043250103 · Cited by 1,546 · see citing works

Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease

Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035477 · Cited by 1,325 · see citing works

Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

Steinberg, M. H., Barton, F. B., Castro, O. L., Pegelow, C. H., Ballas, S. K., Kutlar, A., Orringer, E. P., Bellevue, R., Olivieri, N. F., Eckman, J. R., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1645 · Cited by 928 · see citing works

The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

Herskind, A. M., McGue, M., Holm, N. V., Sørensen, T. I. A., Harvald, B., & Vaupel, J. W. (1996) · Human Genetics · doi:10.1007/bf02185763 · Cited by 879 · see citing works

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

Kato, G. J., Gladwin, M. T., & Steinberg, M. H. (2007) · Blood Reviews · doi:10.1016/j.blre.2006.07.001 · Cited by 876 · see citing works

Sickle-cell disease

Stuart, M. J., & Nagel, R. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17192-4 · Cited by 847 · see citing works

The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease

Castro, O. L., Brambilla, D. J., Thorington, B. D., Reindorf, C. A., Scott, R., GILLETTE, P. N., Vera, J., & Levy, P. S. (1994) · Blood · doi:10.1182/blood.v84.2.643.643 · Cited by 805 · see citing works

Genome-wide association study shows <i>BCL11A</i> associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia

Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711566105 · Cited by 672 · see citing works

The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease

Castro, O. L., Brambilla, D. J., Thorington, B. D., et al. (1994) · Blood · doi:10.1182/blood.v84.2.643.bloodjournal842643 · Cited by 615 · see citing works

DNA polymorphisms at the BCL11A , HBS1L-MYB , and β- globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

Lettre, G., Sankaran, V. G., Bezerra, M., Araujo, A. S., Uda, M., Sanna, S., Cao, A., Schlessinger, D., Costa, F. F., Hirschhorn, J. N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804799105 · Cited by 560 · see citing works

Fetal hemoglobin in sickle cell anemia

Akinsheye, I., Alsultan, A., Solovieff, N., Ngo, D., Baldwin, C. T., Sebastiani, P., Chui, D. H. K., & Steinberg, M. H. (2011) · Blood · doi:10.1182/blood-2011-03-325258 · Cited by 553 · see citing works

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2108 · Cited by 529 · see citing works

Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease [see comments]

Gill, F., Sleeper, L., Weiner, S. R., Ak, B., Bellevue, R., Grover, R., Pegelow, C. H., & Vichinsky, E. P. (1995) · Blood · doi:10.1182/blood.v86.2.776.bloodjournal862776 · Cited by 513 · see citing works

The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: a 17.5 year follow-up

Steinberg, M. H., McCarthy, W. F., Castro, O., Ballas, S. K., Armstrong, F. D., Smith, W., Ataga, K., Swerdlow, P., Kutlar, A., DeCastro, L., et al. (2010) · American Journal of Hematology · doi:10.1002/ajh.21699 · Cited by 486 · see citing works

Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

Somervaille, T. C. P. (2001) · Journal of the Royal Society of Medicine · doi:10.1177/014107680109401119 · Cited by 432 · see citing works

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)

Voskaridou, E., Christoulas, D., Bilalis, A., Plata, E., Varvagiannis, K., Stamatopoulos, G., Sinopoulou, K., Balassopoulou, A., Loukopoulos, D., & Terpos, E. (2010) · Blood · doi:10.1182/blood-2009-05-221333 · Cited by 430 · see citing works

Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea

Steinberg, M. H., Lu, Z.-H., Barton, F. B., Terrin, M. L., Charache, S., Dover, G. J., & Hydroxyurea, T. M. S. O. (1997) · Blood · doi:10.1182/blood.v89.3.1078 · Cited by 407 · see citing works

Sickle Cell Disease as a Cause of Osteonecrosis of the Femoral Head

Milner, P. F. A., Kraus, A. P., Sebes, J. I., Sleeper, L. A., Dukes, K. A., Embury, S. H., Bellevue, R., Koshy, M., Moohr, J. W., & Smith, J. A. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111213252104 · Cited by 384 · see citing works

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Borg, J., Papadopoulos, P., Georgitsi, M., Gutiérrez, L., Grech, G., Fanis, P., Phylactides, M., Verkerk, A. J. M. H., van der Spek, P. J., Scerri, C. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.630 · Cited by 371 · see citing works

Chronic Renal Failure in Sickle Cell Disease: Risk Factors, Clinical Course, and Mortality

Powars, D. R., Elliott-Mills, D. D., Chan, L. S., Niland, J. C., Hiti, A. L., Opas, L. M., & Johnson, C. S. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-8-614 · Cited by 357 · see citing works

Occurrence of hemophilia in the United States

Soucie, J. M., Evatt, B. L., Jackson, D. J., & the Hemophilia Surveillance System Project Investigators (1998) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199812)59:4 · Cited by 347 · see citing works

Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

Paola Sebastiani, B., Ramoni, M. F., Nolan, V., Baldwin, C. T., & Steinberg, M. H. (2005) · Nature Genetics · doi:10.1038/ng1533 · Cited by 333 · see citing works

Predicting clinical severity in sickle cell anaemia

Steinberg, M. H. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05411.x · Cited by 322 · see citing works

Disorders of hemoglobin: Genetics, pathophysiology, and clinical management, second edition

Steinberg, M., Forget, B., Higgs, D., & Weatherall, D. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582 · Cited by 317 · see citing works

The multifunctional role of EKLF/KLF1 during erythropoiesis

Siatecka, M., & Bieker, J. J. (2011) · Blood · doi:10.1182/blood-2011-03-331371 · Cited by 314 · see citing works

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

Thein, S. L., Menzel, S., Xu, P., Best, S., Jiang, J., Close, J. P., Silver, N., Gerovassili, A., Chen, P., Yamaguchi, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611393104 · Cited by 313 · see citing works

Silent cerebral infarcts in sickle cell anemia: a risk factor analysis

Kinney, T. R., Sleeper, L. A., Wang, W. C., Zimmerman, R. A., Pegelow, C. H., Ohene-Frempong, K., Wethers, D. L., Bello, J. A., Vichinsky, E. P., Moser, F. G., et al. (1999) · PEDIATRICS · doi:10.1542/peds.103.3.640 · Cited by 309 · see citing works

Pulmonary hypertension in patients with sickle cell disease: a longitudinal study

Ataga, K. I., Moore, C. G., Jones, S., Olajide, O., Strayhorn, D., Hinderliter, A., & Orringer, E. P. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06110.x · Cited by 298 · see citing works

Genetic influences on F cells and other hematologic variables: a twin heritability study

Garner, C., Tatu, T., Reittie, J. E., Littlewood, T. J., Darley, J. H., Cervino, S., Farrall, M., Kelly, P. J., Spector, T. D., & Thein, S. L. (2000) · Blood · doi:10.1182/blood.v95.1.342.001k33_342_346 · Cited by 273 · see citing works

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

Galarneau, G., Palmer, C. D., Sankaran, V. G., Orkin, S. H., Hirschhorn, J. N., & Lettre, G. (2010) · Nature Genetics · doi:10.1038/ng.707 · Cited by 267 · see citing works

Hematologically and Genetically Distinct Forms of Sickle Cell Anemia in Africa

Nagel, R. L., Fabry, M. E., Pagnier, J., Zohoun, I., Wajcman, H., Baudin‐Creuza, V., & Labie, D. (1985) · New England Journal of Medicine · doi:10.1056/nejm198504043121403 · Cited by 263 · see citing works

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

Thein, S. L., Menzel, S., Lathrop, M., & Garner, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp401 · Cited by 250 · see citing works

Leg ulcers in patients with sickle cell disease [see comments]

Koshy, M., Entsuah, R., Koranda, A., Kraus, A., Johnson, R., Bellvue, R., Flournoy-Gill, Z., & Levy, P. S. (1989) · Blood · doi:10.1182/blood.v74.4.1403.1403 · Cited by 239 · see citing works

Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients.

Labie, D., Pagnier, J., Lapouméroulie, C., Rouabhi, F., Dunda, O., Chardin, P., Beldjord, C., Wajcman, H., Fabry, M. E., & Nagel, R. L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.7.2111 · Cited by 233 · see citing works

Priapism and Impotence in Homozygous Sickle Cell Disease

Emond, A. M. (1980) · Archives of Internal Medicine · doi:10.1001/archinte.1980.00330220022011 · Cited by 229 · see citing works

CSMD1 Is a Novel Multiple Domain Complement-Regulatory Protein Highly Expressed in the Central Nervous System and Epithelial Tissues

Kraus, D., Elliott, G., Chute, H. T., Horan, T. P., Pfenninger, K. H., Sanford, S. D., Foster, S., Scully, S. A., Welcher, A. A., & Holers, V. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4419 · Cited by 218 · see citing works

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

Wilber, A. C., Nienhuis, A. W., & Persons, D. A. (2011) · Blood · doi:10.1182/blood-2010-11-316893 · Cited by 217 · see citing works

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

Sankaran, V. G., Menne, T., Šćepanović, D., Vergilio, J., Ji, P., Kim, J., Thiru, P., Orkin, S. H., Lander, E. S., & Lodish, H. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018384108 · Cited by 214 · see citing works

Hemolysis-associated priapism in sickle cell disease

Nolan, V. G., Wyszynski, D. F., Farrer, L. A., & Steinberg, M. H. (2005) · Blood · doi:10.1182/blood-2005-04-1594 · Cited by 214 · see citing works

Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia

Steinberg, M. H. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.10 · Cited by 202 · see citing works

Discovering the genetics underlying foetal haemoglobin production in adults

Thein, S. L., & Menzel, S. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07650.x · Cited by 200 · see citing works

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

Minniti, C. P., Sable, C., Campbell, A., RANA, S. R., Ensing, G. J., Dham, N., Onyekwere, O. C., Nouraie, M. S., Kato, G. J., Gladwin, M. T., et al. (2009) · Haematologica · doi:10.3324/haematol.13812 · Cited by 186 · see citing works

Silent infarcts in young children with sickle cell disease

Kwiatkowski, J. L., Zimmerman, R. A., Pollock, A. N., Seto, W., Smith‐Whitley, K., Justine Shults, A., Blackwood‐Chirchir, A., & Ohene‐Frempong, K. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07753.x · Cited by 184 · see citing works

Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain

Taylor, J. G., Nolan, V. G., Mendelsohn, L. G., Kato, G. J., Gladwin, M. T., & Steinberg, M. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002095 · Cited by 184 · see citing works

A Functional Element Necessary for Fetal Hemoglobin Silencing

Sankaran, V. G., Xu, J., Byron, R., Greisman, H. A., Fisher, C. A., Weatherall, D. J., Sabath, D. E., Groudine, M. T., Orkin, S. H., Premawardhena, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103070 · Cited by 183 · see citing works

Gene interactions and stroke risk in children with sickle cell anemia

Hoppe, C. C., Klitz, W., Cheng, S., Apple, R. J., Steiner, L. L., Lara, R., Girard, T., Vichinsky, E. P., Styles, L. A., & the CSSCD Investigators (2003) · Blood · doi:10.1182/blood-2003-09-3015 · Cited by 176 · see citing works

Alpha-thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene

Steinberg, M., & Embury, S. (1986) · Blood · doi:10.1182/blood.v68.5.985.985 · Cited by 175 · see citing works

Stroke in sickle cell disease: demographic, clinical, and therapeutic considerations.

Ohene‐Frempong, K. (1991) · PubMed · Cited by 174 · see citing works

cMYB is involved in the regulation of fetal hemoglobin production in adults

Jiang, J., Best, S., Menzel, S., Silver, N., Lai, M. I., Surdulescu, G. L., Spector, T. D., & Thein, S. L. (2006) · Blood · doi:10.1182/blood-2006-01-008912 · Cited by 174 · see citing works

BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies

Sedgewick, A. E., Timofeev, N., Sebastiani, P., So, J. C. C., Ma, E. S. K., Chan, L. C., Fucharoen, G., Fucharoen, S., Barbosa, C. G., Vardarajan, B. N., et al. (2008) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2008.06.007 · Cited by 172 · see citing works

Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF‐ β /BMP pathway

Nolan, V. G., Adewoye, A. H., Baldwin, C. T., Wang, L., Ma, Q., Wyszynski, D. F., Farrell, J. J., Paola Sebastiani, B., Farrer, L. A., & Steinberg, M. H. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06074.x · Cited by 171 · see citing works

Glomerular Hyperfiltration in Adult Sickle Cell Anemia

Haymann, J., Stankovic, K., Lévy, P., Avellino, V., Tharaux, P., Letavernier, E., Grateau, G., Baud, L., Girot, R., & Lionnet, F. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08511109 · Cited by 167 · see citing works

G6PD deficiency, absence of α-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia

Bernaudin, F., Verlhac, S., Chevret, S., Torres, M., Coic, L., Arnaud, C., Kamdem, A., Hau, I., Grazia Neonato, M., & Delacourt, C. (2008) · Blood · doi:10.1182/blood-2008-03-143891 · Cited by 162 · see citing works

MYH9 and APOL1 are both associated with sickle cell disease nephropathy

Ashley‐Koch, A. E., Okocha, E. C., Garrett, M. E., Soldano, K. L., Castro, L. M. D., Jonassaint, J., Orringer, E. P., Eckman, J. R., & Telen, M. J. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08832.x · Cited by 161 · see citing works

A network model to predict the risk of death in sickle cell disease

Paola Sebastiani, B., Nolan, V. G., Baldwin, C. T., Abad‐Grau, M. M., Wang, L., Adewoye, A. H., McMahon, L. C., Farrer, L. A., Taylor, J. G., Kato, G. J., et al. (2007) · Blood · doi:10.1182/blood-2007-04-084921 · Cited by 161 · see citing works

Genetic predictors for stroke in children with sickle cell anemia

Flanagan, J. M., Frohlich, D. M., Howard, T. A., Schultz, W. H., Driscoll, C. E., Nagasubramanian, R., Mortier, N. A., Kimble, A. C., Aygün, B., Adams, R. J., et al. (2011) · Blood · doi:10.1182/blood-2011-01-332205 · Cited by 147 · see citing works

Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom

Sachdev, V., Kato, G. J., Gibbs, J. S. R., Barst, R. J., Machado, R. F., Nouraie, M., Hassell, K. L., Little, J. A., Schraufnagel, D. E., Krishnamurti, L., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.032920 · Cited by 147 · see citing works

Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences

Hughes, J. R., Cheng, J., Ventress, N., Prabhakar, S., Clark, K., Anguita, E., Gobbi, M. D., de Jong, P., Rubin, E., & Higgs, D. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503401102 · Cited by 146 · see citing works

Fetal haemoglobin levels and haematological characteristics of compound heterozygotes for haemoglobin S and deletional hereditary persistence of fetal haemoglobin

Ngo, D. A., Aygun, B., Akinsheye, I., Hankins, J. S., Bhan, I., Luo, H. Y., Steinberg, M. H., & Chui, D. H. K. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08916.x · Cited by 142 · see citing works

Two different forms of homozygous sickle cell disease occur in Saudi Arabia

Padmos, M. A., Sackey, K., Roberts, G. T., Kulozik, A. E., Bail, S., Morris, J., Serjeant, B. E., & Serjeant, G. R. (1991) · British Journal of Haematology · doi:10.1111/j.1365-2141.1991.tb08013.x · Cited by 141 · see citing works

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5′ olfactory receptor gene cluster

Solovieff, N., Milton, J. N., Hartley, S. W., Sherva, R., Paola Sebastiani, B., Dworkis, D. A., Klings, E. S., Farrer, L. A., Garrett, M. E., Ashley‐Koch, A. E., et al. (2009) · Blood · doi:10.1182/blood-2009-08-239517 · Cited by 141 · see citing works

Renal Function in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial

Ware, R. E., Rees, R. C., Sarnaik, S. A., Iyer, R. V., Alvarez, O. A., Casella, J. F., Shulkin, B. L., Shalaby-Rana, E. I., Strife, C. F., Miller, J. H., et al. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.06.060 · Cited by 138 · see citing works

Genetic modifiers of the β‐haemoglobinopathies

Thein, S. L. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07084.x · Cited by 137 · see citing works

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea

Ma, Q., Wyszynski, D. F., Farrell, J. J., Kutlar, A., Farrer, L. A., Baldwin, C. T., & Steinberg, M. H. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500433 · Cited by 125 · see citing works

Association between hemolysis and albuminuria in adults with sickle cell anemia

Day, T. G., Drašar, E., Fulford, T. J., Sharpe, C. C., & Thein, S. L. (2011) · Haematologica · doi:10.3324/haematol.2011.050336 · Cited by 122 · see citing works

The effect of fetal hemoglobin on the survival characteristics of sickle cells

Franco, R. S., Yasin, Z., Palascak, M. B., Ciraolo, P., Joiner, C. H., & Rucknagel, D. L. (2006) · Blood · doi:10.1182/blood-2005-09-008318 · Cited by 119 · see citing works

A novel sickle cell mutation of yet another origin in Africa: the Cameroon type

Lapouni�roulie, C., Dunda, O., Ducrocq, R., Trabuchet, G., Mony-Lob�, M., Bodo, J.-M., Carnevale, P., Labie, D., Élion, J., & Krishnamoorthy, R. (1992) · Human Genetics · doi:10.1007/bf00220553 · Cited by 119 · see citing works

Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial

Rogers, Z. R., Wang, W. C., Luo, Z., Iyer, R. V., Shalaby-Rana, E. I., Dertinger, S. D., Shulkin, B. L., Miller, J. H., Files, B., Lane, P. A., et al. (2011) · Blood · doi:10.1182/blood-2010-04-278747 · Cited by 115 · see citing works

A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression

Farrell, J. J., Sherva, R., Chen, Z.-Y., Luo, H., Chu, B. F., Ha, S., Li, C. K., Lee, A., Li, R. C. H., Li, C. K., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317081 · Cited by 114 · see citing works

Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis

Baldwin, C. T., Nolan, V. G., Wyszynski, D. F., Ma, Q., Paola Sebastiani, B., Embury, S. H., Bisbee, A. B., Farrell, J. J., Farrer, L. A., & Steinberg, M. H. (2005) · Blood · doi:10.1182/blood-2005-02-0548 · Cited by 110 · see citing works

Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease

Taylor, J. G., Tang, D. C., Savage, S. A., Leitman, S. F., Heller, S. I., Serjeant, G. R., Rodgers, G. P., & Chanock, S. J. (2002) · Blood · doi:10.1182/blood-2001-12-0306 · Cited by 108 · see citing works

Stroke risk in siblings with sickle cell anemia

Driscoll, M. C. (2003) · Blood · doi:10.1182/blood.v101.6.2401 · Cited by 108 · see citing works

Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

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Biomarker signatures of sickle cell disease severity

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Systematic Review of l ‐glutamine for Prevention of Vaso‐occlusive Pain Crisis in Patients with Sickle Cell Disease

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Mortality in adults with sickle cell disease: Results from the sickle cell disease implementation consortium (SCDIC) registry

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Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

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Genetic therapies for the first molecular disease

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Potential utility of melatonin as an antioxidant therapy in the management of sickle cell anemia

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Acute chest syndrome of sickle cell disease: genetics, risk factors, prognosis, and management

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Turf wars: exploring splenomegaly in sickle cell disease in malaria‐endemic regions

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The genetics of hemoglobin A2 regulation in sickle cell anemia

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Overview of Sickle Cell Anemia Pathophysiology

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Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes

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Genetic modifiers of severity in sickle cell disease

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Preoperative blood transfusions for sickle cell disease

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Genomic approaches to identifying targets for treating β hemoglobinopathies

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Interventions for chronic kidney disease in people with sickle cell disease

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Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1

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Stroke in sickle cell anemia patients: A need for multidisciplinary approaches

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HYDROXYCARBAMINE: FROM AN OLD DRUG USED IN MALIGNANT HEMOPATHIES TO A CURRENT STANDARD IN SICKLE CELL DISEASE

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Treating sickle cell anemia: A new era dawns

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Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin level and clinical outcomes in a cohort of children with sickle cell anemia

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Endothelial dysfunction in Sickle Cell Disease: Strategies for the treatment

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Loss-of-function mutation survey revealed that genes with background-dependent fitness are rare and functionally related in yeast

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What's New in the Pathophysiology of Sickle Cell Disease?

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Acute chest syndrome is associated with single nucleotide polymorphism‐defined beta globin cluster haplotype in children with sickle cell anaemia

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A Call for Policy Action in Sub-Saharan Africa to Rethink Diagnostics for Pregnancy Affected by Sickle Cell Disease: Differential Views of Medical Doctors, Parents and Adult Patients Predict Value Conflicts in Cameroon

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Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study

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Sickle cell disease in India: the journey and hope for the future

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Significance of genetic modifiers of hemoglobinopathies leading towards precision medicine

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Sickle cell disease in Madhya Pradesh, Central India: A comparison of clinical profile of sickle cell homozygote vs. sickle-beta thalassaemia individuals

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Potential involvement of ubiquitin‐proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease

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Prevalence and diversity of haplotypes of sickle cell disease in the Eastern Province of Saudi Arabia

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Genetic Factors Modifying Sickle Cell Disease Severity

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Genetic Modulation of Sickle Cell Disease and Thalassemia

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Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease

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Sickle Cell Disease as a Multifactorial Condition

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