Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease
Open accessAbstract
Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the ages of 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here, we further analyzed data collected on enrolled CSSCD infants for the predictive value of those markers for stroke and death later in life. Three hundred fifty‐four CSSCD subjects were identified who had absolute reticulocyte counts (ARC) measured during infancy (2 to 6 months of age). Infants with higher ARC had significantly increased risk of stroke or death during childhood; lower hemoglobin levels also increased the risk but to a lesser degree than ARC. WBC levels and dactylitis were not predictive of death or stroke. These data suggest that reticulocytosis among asymptomatic infants with sickle cell anemia is associated with an increased risk of death or stroke during childhood. Am. J. Hematol. 89:904–906, 2014. © 2014 Wiley Periodicals, Inc.
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Reticulocytosis, low HbF levels, leukocytosis, and complications such as acute chest syndrome are associated with increased risk of stroke in sickle cell disease.
“Observational studies have shown that reticulocytosis (149), low HbF levels, leukocytosis (150, 151), and complications such as ACS (81) are associated with an increased risk of stroke.”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [149]
The Results and Discussion report that reticulocytosis in early infancy was associated with increased risk of the combined outcome of stroke or death during childhood. They do not establish an increased risk of stroke alone. Citation 149 is attached to reticulocytosis; the other listed factors are not attributed to this source by that citation. (LLM, conf=0.85)
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Cites
Improved survival of children and adolescents with sickle cell disease
Quinn, C. T., Rogers, Z. R., McCavit, T. L., & Buchanan, G. R. (2010) · Blood · doi:10.1182/blood-2009-07-233700 · Cited by 904 · see citing works
Gill, F., Sleeper, L., Weiner, S. R., Ak, B., Bellevue, R., Grover, R., Pegelow, C. H., & Vichinsky, E. P. (1995) · Blood · doi:10.1182/blood.v86.2.776.bloodjournal862776 · Cited by 513 · see citing works
Prediction of Adverse Outcomes in Children with Sickle Cell Disease
Miller, S. T., Sleeper, L. A., Pegelow, C. H., Enos, L. E., Wang, W. C., Weiner, S. J., Wethers, D. L., Smith, J., & Kinney, T. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001133420203 · Cited by 508 · cited 3× · see citing works
“Because steady state hemoglobin and WBC counts were identified as important markers of disease severity in earlier reports [3], the association of hemoglobin and WBC count early in life with death and stroke was also examined.”
BackgroundMethodNathan And Oski's Hematology Of Infancy And Childhood
Saxon, B. R. (2004) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2004.00352.x · Cited by 417 · see citing works
Role of erythrocyte phosphatidylserine in sickle red cell–endothelial adhesion
Setty, Y. B. N., Kulkarni, S., & Stuart, M. J. (2002) · Blood · doi:10.1182/blood.v99.5.1564 · Cited by 211 · see citing works
Styles, L. A., Lubin, B. H., Vichinsky, E. P., Lawrence, S., Hua, M., Test, S. T., & Kuypers, F. A. (1997) · Blood · doi:10.1182/blood.v89.7.2554 · Cited by 155 · see citing works
Laboratory profile of sickle cell disease: a cross-sectional analysis
STEWARTWEST, M. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90073-v · Cited by 136 · see citing works
Reference Values and Hematologic Changes From Birth to 5 Years in Patients With Sickle Cell Disease
Brown, A. K. (1994) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1994.02170080026005 · Cited by 108 · see citing works
Quinn, C. T., Lee, N. J., Shull, E. P., Ahmad, N., Rogers, Z. R., & Buchanan, G. R. (2007) · Blood · doi:10.1182/blood-2007-07-100719 · Cited by 90 · see citing works
Lebensburger, J. D., Miller, S. T., Howard, T. H., Casella, J. F., Brown, C., Lü, M., Iyer, R. V., Sarnaik, S. A., Rogers, Z. R., Wang, W. C., et al. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.24037 · Cited by 80 · see citing works
Disorders of the synthesis of human fetal hemoglobin
Manca, L., & Masala, B. (2008) · IUBMB Life · doi:10.1002/iub.4 · Cited by 70 · see citing works
Evaluation of the Sysmex R-1000®: An Automated Reticulocyte Analyzer
Tichelli, A., Gratwohl, A. A., Driessen, A., Mathys, S., Pfefferkorn, E., Regenass, A., Schumacher, P., Stebler, C., Wernli, M., Nissen, C., et al. (1990) · American Journal of Clinical Pathology · doi:10.1093/ajcp/93.1.70 · Cited by 55 · see citing works
Hayes, R. J., Beckford, M., Grandison, Y., Mason, K., Serjeant, B. E., & Serjeant, G. R. (1985) · British Journal of Haematology · doi:10.1111/j.1365-2141.1985.tb03002.x · Cited by 55 · see citing works
Silva, C. M., Giovani, P., & Viana, M. B. (2010) · Pediatric Blood & Cancer · doi:10.1002/pbc.22680 · Cited by 43 · see citing works
Meier, E. R., Byrnes, C., Lee, Y. T., Wright, E. C., Schechter, A. N., Luban, N. L. C., & Miller, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070794 · Cited by 25 · see citing works
Self-citationBray, G. L., Muenz, L. R., Makris, N., & Lessin, L. S. (1994) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813 · see citing works
Determinants of severity in sickle cell disease
Rees, D. C., Brousse, V. A. M., & Brewin, J. N. (2022) · Blood Reviews · doi:10.1016/j.blre.2022.100983 · Cited by 83 · see citing works
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome
Lebensburger, J. D., Palabindela, P., Howard, T. H., Feig, D. I., Aban, I., & Askenazi, D. J. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3370-0 · Cited by 42 · see citing works
“For every 1 unit drop in Hb from baseline to admission, the odds of AKI is estimated to increase by about 81 % While prior research has identified severe anemia at baseline as a risk factor for overall disease severity in pediatric SCD, clinicians should also consider an acute drop in Hb from baseline as a risk factor…”
Bello‐Manga, H., DeBaun, M. R., & Kassim, A. A. (2016) · Expert Review of Hematology · doi:10.1080/17474086.2016.1240612 · Cited by 39 · see citing works
Measuring success: utility of biomarkers in sickle cell disease clinical trials and care
Kalpatthi, R. V., & Novelli, E. M. (2018) · Hematology · doi:10.1182/asheducation-2018.1.482 · Cited by 44 · see citing works
Sommet, J., Alberti, C., Couque, N., Verlhac, S., Haouari, Z., Mohamed, D., François, M., Missud, F., Holvoet, L., Elmaleh, M., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.13916 · Cited by 38 · see citing works
“Reticulocytosis is also known to be associated with an increased risk of stroke during childhood (Meier et al, 2014).”
BackgroundErythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology
Brousse, V. A. M., Colin, Y., Pereira, C., Arnaud, C., Odièvre, M. H., Boutemy, A., Guitton, C., de Montalembert, M., Lapouméroulie, C., Picot, J., et al. (2014) · EBioMedicine · doi:10.1016/j.ebiom.2014.12.006 · Cited by 38 · see citing works
“This is an open access article under 2011) and the absolute reticulocyte count is already elevated in the first semester of life, arguing for the very early onset of haemolysis despite high HbF levels (Meier et al., 2013, 2014).”
BackgroundCarden, M. A., Fasano, R. M., & Meier, E. R. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100637 · Cited by 36 · see citing works
“As the ARC increased above 200 K/uL, the association with more severe SCA became stronger.[14, 15, 89]”
BackgroundSelf-citationA systematic review of the literature for severity predictors in children with sickle cell anemia
Meier, E. R., Fasano, R. M., & Levett, P. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.01.014 · Cited by 33 · see citing works
“Two studies included children who received universal newborn screening, early penicillin prophylaxis and routine TCD screening [18,39] and two studies utilized data from children enrolled in the CSSCD [21,40].”
BackgroundMethodSelf-citationBelisário, A. R., Sales, R. R., Toledo, N. E., Muniz, M. B. D. S. R., Velloso-Rodrigues, C., Silva, C. M., & Viana, M. B. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2789-5 · Cited by 29 · see citing works
Green, N., Munube, D., Bangirana, P., Buluma, L. R., Kebirungi, B., Opoka, R. O., Mupere, E., Kasirye, P., Kiguli, S., Birabwa, A., et al. (2019) · BMC Pediatrics · doi:10.1186/s12887-019-1758-2 · Cited by 30 · see citing works
Chronic organ injuries in children with sickle cell disease
Allali, S., Taylor, M., Brice, J., & de Montalembert, M. (2021) · Haematologica · doi:10.3324/haematol.2020.271353 · Cited by 25 · see citing works
Olatunya, O. S., Oke, O. J., Kuti, B. P., Ajayi, I. A., Olajuyin, O. A., Omotosho-Olagoke, O., Taiwo, A. B., Faboya, O. A., & Ajibola, A. (2017) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmx034 · Cited by 25 · see citing works
Rankine‐Mullings, A., Reid, M. E., Soares, D., Taylor‐Bryan, C., Wisdom‐Phipps, M., Aldred, K., Latham, T., Schultz, W. H., Knight‐Madden, J., Badaloo, A. V., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17698 · Cited by 24 · see citing works
“87) 0 2627 TCD velocity (cm/s) mean (SD) 169 (29) 188 (15) 211 (58) – Previous medical history, n (%) Vaso-occlusive crisis 7 (58) 14 (67) 5 (50) 26 (60) Dactylitis 4 (33) 9 (43) 5 (50) 18 (42) Acute chest syndrome 8 (67) 16 (76) 9 (90) 33 (77) Acute splenic sequestration 6 (50) 5 (25) 1 (10) 12 (29) Hospitalizations,…”
Belisário, A. R., Silva, C. M., Velloso‐Rodrigues, C., & Viana, M. B. (2017) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.bjhh.2017.08.008 · Cited by 24 · see citing works
Gallivan, A., Alejandro, M., Kanu, A., Zekaryas, N., Horneman, H. F., Hong, L. K., Vinchinsky, E., Lavelle, D., Diamond, A. M., Molokie, R. E., et al. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.02.005 · Cited by 22 · see citing works
Meier, E. R., Fasano, R. M., Estrada, M., He, J., Luban, N. L. C., & McCarter, R. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.10.031 · Cited by 22 · see citing works
Self-citationBelisário, A. R., Sales, R. R., de Toledo, N. E., Velloso‐Rodrigues, C., Silva, C. M., & Viana, M. B. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.25924 · Cited by 21 · see citing works
Bello‐Manga, H., Galadanci, A. A., Abdullahi, S. U., Ali, S., Jibir, B. W., Gambo, S., Haliru, L., Jordan, L. C., Aliyu, M. H., Rodeghier, M., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.16746 · Cited by 19 · see citing works
Sadreameli, S. C., Eakin, M. N., Robinson, K. T., Alade, R. O., & Strouse, J. J. (2015) · American Journal of Hematology · doi:10.1002/ajh.24281 · Cited by 18 · see citing works
Rai, P., Joshi, V. M., Goldberg, J. F., Yates, A. M., Okhomina, V. I., Penkert, R. R., Ataga, K. I., Kang, G., & Hankins, J. S. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003197 · Cited by 16 · see citing works
Jung, J., Lu, Z., de Smith, A. D., & Mancuso, N. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad174 · Cited by 16 · see citing works
“Previous studies showed that high reticulocyte count or reticulocytosis are risk factors for stroke in children with sickle cell disease [41–43].”
ResultAbdul-Hussein, H. K., Al-Mamoori, H. S., & Hassan, M. K. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155534 · Cited by 15 · see citing works
Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia
Karkoska, K. A., Quinn, C. T., Niss, O., Pfeiffer, A., Dong, M., Vinks, A. A. T. M. M., & McGann, P. T. (2021) · American Journal of Hematology · doi:10.1002/ajh.26120 · Cited by 12 · see citing works
“The majority of circulating oxygen within the body is bound to hemoglobin; indeed, a lower hemoglobin concentration is associated with both ischemic and hemorrhagic stroke risk in SCA.24-26 The cerebral metabolic rate of oxygen use is dependent on the cerebral arterial oxygen content, cerebral blood flow, and oxygen e…”
BackgroundInfluentialExamination of Reticulocytosis among Chronically Transfused Children with Sickle Cell Anemia
Kaushal, M., Byrnes, C., Khademian, Z. P., Duncan, N., Luban, N. L. C., Miller, J. L., Fasano, R. M., & Meier, E. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153244 · Cited by 12 · see citing works
“Based upon the recent use of ARC as a predictive marker for SCA pathologies (including cerebrovascular disease) [20,21,27], we hypothesized that higher ARC levels among CTT patients may predict more severe cerebrovascular disease.”
MethodSelf-citationPecker, L. H., & Ackerman, H. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_7 · Cited by 10 · see citing works
Ismail, A., Yusuf, A. A., Kuliya‐Gwarzo, A., Ahmed, S. G., Tabari, A. M., & Abubakar, S. A. (2019) · Ultrasound · doi:10.1177/1742271x19836264 · Cited by 10 · see citing works
Sabarense, A. P., Silva, C. M., Muniz, M. B. D. S. R., & Viana, M. B. (2021) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2021.05.001 · Cited by 10 · see citing works
“Basal leukocytes and dactylitis, previously considered relevant, were not significant when adjusted for reticulocyte count.(26)”
BackgroundEchocardiographic Evaluation in Paediatric Sickle Cell Disease Patients: A Pilot Study
Sabatini, L., Chinali, M., Franceschini, A., Mauro, M. D., Marchesani, S., Fini, F., Arcuri, G., Lodi, M., Palumbo, G. A., & Ceglie, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010007 · Cited by 9 · see citing works
“In the literature, the increase in absolute reticulocyte count has been linked with other acute and chronic complications of SCD in paediatric age patients, such as cerebral vasculopathy (stroke, increased trans-cranial Doppler velocity, silent stroke) [52,53], hospitalizations for splenic sequestration, vaso-occlusiv…”
BackgroundBiomarkers and recent advances in the management and therapy of sickle cell disease
Telen, M. J. (2015) · F1000Research · doi:10.12688/f1000research.6615.1 · Cited by 9 · see citing works
Fatores de risco para mortalidade em pacientes com doença falciforme: uma revisão integrativa
Pompeo, C. M., Cardoso, A. I. D. Q., Souza, M. D. C., Ferraz, M. B., Júnior, M. A. F., & Ivo, M. L. (2020) · Escola Anna Nery · doi:10.1590/2177-9465-ean-2019-0194 · Cited by 11 · see citing works
Varied Age of First Presentation of Sickle Cell Disease: Case Presentations and Review
Claeys, A., Steijn, S. V., Kesteren, L. V., Damen, E. D., & van den Akker, M. (2021) · Case Reports in Medicine · doi:10.1155/2021/8895020 · Cited by 7 · see citing works
Sahun, M., Bernit, E., Atwell, S. X., Hornung, A., Charrier, A. M., Agouti, I., Bonello‐Palot, N., Cérino, M., Helfer, E., Badens, C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-00152-w · Cited by 6 · see citing works
Olatunya, O. S., Olu‐Taiwo, A., Ogundare, E. O., Oluwayemi, I. O., Olaleye, A. O., Fadare, J. O., Adekoya-Benson, T., Fatunla, O. A., Agaja, O. T., Omoniyi, E., et al. (2016) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmw015 · Cited by 6 · see citing works
Poverty and severity of childhood sickle cell disease
Olatunya, O. S. (2020) · British Journal of Haematology · doi:10.1111/bjh.16816 · Cited by 5 · see citing works
Ogbenna, A. A., Akinsete, A. M., Kalejaiye, O. O., Oyewole, K. M., Sharma, D., Andrews, J. C., & Kassim, A. A. (2022) · British Journal of Haematology · doi:10.1111/bjh.18313 · Cited by 5 · see citing works
Meier, E. R., Byrnes, C., Weissman, M., Lee, Y. T., & Miller, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136672 · Cited by 5 · see citing works
“Our prior studies demonstrated a predictive value of decreased reticulocytosis for decreased disease severity in infants with SCA [12,13].”
BackgroundMethodInfluentialSelf-citationKossorotoff, M., de Montalembert, M., Brousse, V. A. M., Lasne, D., Curis, E., Smadja, D. M., Lacroix, R., Bertil, S., Masson, E., Desguerre, I., et al. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9835-8 · Cited by 4 · see citing works
Yurtsever, N., Tong, N., Geetha, S. D., Nandi, V., & Shi, P. A. (2024) · Transfusion · doi:10.1111/trf.18044 · Cited by 3 · see citing works
Kamel, S. M., Nassim, M. S., Mohamed, M. A., & Abdelrahman, S. F. (2022) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-022-00936-4 · Cited by 2 · see citing works
Taques, W. D. O., Bett, G. C., de Moraes, B. L. B., Medeiros, I., Fontes, C. J. F., & de Oliveira, R. G. (2024) · Hemoglobin · doi:10.1080/03630269.2023.2301490 · Cited by 2 · see citing works
Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias
FRCPath, B. J. B. M. B. F. (2020) · Wiley eBooks · doi:10.1002/9781119579977.ch4 · Cited by 2 · see citing works
Jung, J., Lu, Z., de Smith, A. J., & Mancuso, N. (2023) · medRxiv · doi:10.1101/2023.03.30.23287918 · Cited by 2 · see citing works
Optimizing the right time to start sickle cell therapies
Martin, O. Y., & Jacob, S. A. (2025) · Hematology · doi:10.1182/hematology.2025000752 · Cited by 2 · see citing works
Andemariam, B., Kuo, K. H. M., Algahtani, F. H., Kindi, S. A., Ataga, K. I., Bartolucci, P., Campbell, A., Colombatti, R., Glaros, A. K., Hafraoui, K., et al. (2026) · The Lancet · doi:10.1016/s0140-6736(26)01480-7 · Cited by 1 · see citing works
Risk-Based Therapies for Sickle Cell Disease
Meier, E. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-62328-3_4 · Cited by 1 · see citing works
Self-citationHarnessing the potential of red blood cells in immunotherapy
Jajosky, R. P., Zerra, P. E., Chonat, S., Stowell, S. R., & Arthur, C. M. (2024) · Human Immunology · doi:10.1016/j.humimm.2024.111084 · Cited by 1 · see citing works
Anemia at the Extremes of Life: Congenital Hemolytic Anemia
Reinish, A. L., & Noronha, S. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-96487-4_6 · Cited by 1 · see citing works
Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias
FRCPath, B. J. B. M. F., & Rees, D. C. (2024) · Wiley eBooks · doi:10.1002/9781394265381.ch4 · Cited by 1 · see citing works
Precision Medicine for Sickle Cell Disease: Discovery of Genetic Targets for Drug Development
Pace, B. S., Lopez, N. H., Zhu, X., & Li, Y. (2016) · InTech eBooks · doi:10.5772/64817
“Other types of VOC events include acute chest syndrome [22, 23], silent and acute cerebral infarcts [24, 25], and osteonecrosis of the femoral head.”
BackgroundErythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights
Brousse, V. A. M., Colin, Y., Santos‐Pereira, C., Odièvre, M. H., Boutemy, A., de Montalembert, M., Picot, J., & Kim, C. L. V. (2015)
Hypotonia, Weakness, and Stroke
Konersman, C. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-39956-2.00029-7
The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease
Nickel, R. S., & Kamani, N. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-62328-3_9
Desnos, L., Allaert, F., Etienne‐Julan, M., & Blanchet‐Deverly, A. (2019) · JMV-Journal de Médecine Vasculaire · doi:10.1016/j.jdmv.2019.04.008
Farias‐Moeller, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-76174-1.00037-7
Pincez, T. (2026) · American Journal of Hematology · doi:10.1002/ajh.70214
“Several risk factors have been identified as increasing the risk of CV: hemoglobin SS or S-beta 0 - thalassemia type [2], lower hemoglobin level [2], high reticulocyte count [9], high systolic blood pressure [2], frequent acute chest syndrome [2], low fetal hemoglobin [10].”
Ansong‐Ansongton, Y. O. N., Bamac, D. Z., & Rivers, A. E. (2026) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.05.003
Shaoba, A., Zhang, Y., Gruessner, A. G., Nnaji, O., Mongia, A. K., & Bamgbola, O. F. (2026) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000003295
- Authors
- Meier, E. R., Wright, E. C., & Miller, J. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Miller, Jeffery L.
- Venue
- American Journal of Hematology
- Publisher
- Wiley
- Published
- 2014-06-19
- Volume
- 89
- Issue
- 9
- Pages
- 904-906
- ISSN
- 0361-8609 (ISSN-L)
- 1096-8652
- PMC
- PMC4134755
- OpenAlex
- W1958232709
- Cited by
- 59
- References
- 16
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 1
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Hematology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000075, KL2TR000076)
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (Z01DK025099)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- sickle cell disease, reticulocytosis, stroke, mortality, hemoglobin, white blood cell count, dactylitis, disease severity prediction, child outcomes
- MeSH terms
- Anemia, Sickle Cell, Child, Preschool, Female, Hemoglobins, Humans, Infant, Infant, Newborn, Leukocyte Count, Male, Predictive Value of Tests, Reticulocytes, Risk, Reticulocyte Count, Stroke, Reticulocytosis, Kaplan-Meier Estimate
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