Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes
Abstract
Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. © 1993 Wiley‐Liss, Inc.
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PS on the outer leaflet of RBCs is a target mediator of PLT activation, resulting in enhanced aggregation.
“In addition, PS on the outer leaflet of RBCs was identified to be a target mediator of PLT activation, resulting in enhanced aggregation (23).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [23]
Cites
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Transbilayer movement of phospholipids in red cell and platelet membranes
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Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology
Hebbel, R. (1991) · Blood · doi:10.1182/blood.v77.2.214.214 · Cited by 300 · see citing works
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Self-citationA chronic hypercoagulable state and life-long platelet activation in beta thalassemia major.
Eldor, A., Maclouf, J., Lellouche, F., et al. (1993) · PubMed · Cited by 35 · see citing works
Self-citationSUSCEPTIBILITY OF THALASSEMIC RED BLOOD CELLS TO PHAGOCYTOSIS BY HUMAN MACROPHAGES IN VITRO
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Self-citationProthrombinase Complex as a Tool to Assess Changes in Membrane Phospholipid Asymmetry
Comfurius, P., Bevers, E. M., & Zwaal, R. F. A. (2003) · Humana Press eBooks · doi:10.1385/0-89603-250-7:131 · Cited by 8 · see citing works
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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469 · see citing works
Wood, B., Gibson, D., & Tait, J. (1996) · Blood · doi:10.1182/blood.v88.5.1873.1873 · Cited by 445 · see citing works
- Authors
- Yashar, V. B., Barenholz, Y., Hy‐Am, E., Rachmilewitz, E. A., & Eldor, A.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- Corresponding author
- Barenholz, Yechezkel
- ORCID
- Barenholz, Yechezkel
- Venue
- American Journal of Hematology
- Publisher
- Wiley
- Published
- 1993-09
- Volume
- 44
- Issue
- 1
- Pages
- 63-65
- ISSN
- 0361-8609 (ISSN-L)
- 1096-8652
- OpenAlex
- W2060914259
- Cited by
- 166
- References
- 11
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 11
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl017576-18)
- National Heart, Lung, and Blood Institute (HL17576)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- phosphatidylserine, beta-thalassemia, erythrocyte membrane, outer leaflet, hypercoagulability, thrombosis, prothrombinase activity, phagocytosis, macrophages, platelet activation
- MeSH terms
- Blood Coagulation Disorders, Erythrocyte Membrane, Erythrocytes, Humans, Macrophages, Phagocytosis, Phosphatidylserines, Thrombosis, Platelet Activation, beta-Thalassemia
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