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Cited by 194High Altitude and HypoxiaBirth, Development, and HealthPregnancy and preeclampsia studies

Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude

Moore, Lorna G., Young, David, McCullough, Robert E., Droma, Tarshi, Zamudio, Stacy·2001·American Journal of Human Biology
DOI 10.1002/ajhb.1102
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Abstract

Chronic hypoxia at high altitude restricts fetal growth, reducing birth weight and increasing infant mortality. We asked whether Tibetans, a long‐resident high‐altitude population, exhibit less altitude‐associated intrauterine growth restriction (IUGR) and prenatal or postnatal reproductive loss than Han (ethnic Chinese), a group that has lived there for a shorter period of time. A population sample was obtained, comprising 485 deliveries to Tibetan or Han women over an 18‐month period at 8 general hospitals or clinics located at 2,700–4,700 m in the Tibet Autonomous Region, China. Birth weight, gestational age, and other information were recorded for each delivery. Prenatal and postnatal mortality were calculated using information obtained from all pregnancies or babies born to study participants. Tibetan babies weighed more than the Han, averaging 310 g heavier at altitudes 2,700–3,000 m (95% CI = 126, 494 g; P < 0.01) and 530 g heavier at 3,000–3,800 m (210, 750 g; P < 0.01). More Han than Tibetan babies were born prematurely. Prenatal and postnatal mortality rose with increasing elevation and were 3‐fold higher across all altitudes in the Han than the Tibetans (P < 0.05). Tibetans experience less altitude‐associated IUGR than Han and have lower levels of prenatal and postnatal mortality. When the relationships between birth weight and altitude are compared among these and other high‐altitude populations, those living at high altitude the longest have the least altitude‐associated IUGR. This may suggest the occurrence of an evolutionary adaptation. Am. J. Hum. Biol. 13:635–644, 2001. © 2001 Wiley‐Liss, Inc.

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  • Lower birth weight at higher altitudes is seen with both long and short residency at high altitude regardless of nutrition or socioeconomic class.

    “Lower birth weight at higher altitudes is seen with both long and short residency at high altitude regardless of nutrition or socioeconomic class (214, 386, 389).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [389]

  • Pregnant Tibetan women have higher uterine artery diameters and blood velocity than Han women at high altitude, while Andean women have twice the increment in uterine artery diameter during pregnancy than European women at high altitude.

    “Pregnant Tibetan women have higher uterine artery diameters and blood velocity than Han women at high altitude (107, 389), while Andean women have twice the increment in uterine artery diameter during pregnancy than European women at high altitude (295, 577, 604).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [389]

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Authors
Moore, L. G., Young, D., McCullough, R. E., Droma, T., & Zamudio, S.
Affiliations
  • University of Colorado Denver (US)
  • Tibet Autonomous Region People's Hospital (CN)
Corresponding author
Moore, Lorna G.
ORCID
Venue
American Journal of Human Biology
Publisher
Wiley
Published
2001-08-08
Volume
13
Issue
5
Pages
635-644
ISSN
  • 1042-0533 (ISSN-L)
  • 1520-6300
DOI
10.1002/ajhb.1102
OpenAlex
W2112861264
Cited by
194
References
30
Citations by year
2026: 6 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 5
FWCI
4.56
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • American Journal of Human Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL060131, HL60131)
  • Division of Chemistry
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
fetal growth restriction, high altitude, Tibetan population, Han Chinese, birth weight, fetal growth, prenatal mortality, postnatal mortality, chronic hypoxia, high-altitude adaptation, gestational age, ethnic differences
MeSH terms
Adult, Altitude, Birth Weight, Female, Fetal Death, Fetal Growth Retardation, Humans, Infant Mortality, Infant, Newborn, Linear Models, Tibet

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