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On the statistical determination of major gene mechanisms in continuous human traits: Regressive models
Abstract
We consider the analysis of a continuous trait measured on human families and pedigrees to elucidate the mechanism of underlying major genes. Thinking in terms of the naturally Markovian structure of the dependencies in pedigrees rather than variance components, we describe natural classes of regressive models that are computationally feasible. These models can accommodate wide generalizations of the residual variation, and so should provide a stronger basis than other models. proposed to date for inferring the segregation and linkage relationships of major genes.
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Citations
Cited by
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,413
Cox, N. J., Frigge, M., Nicolae, D. L., Concannon, P., Hanis, C. L., Bell, G. I., & Kong, A. (1999) · Nature Genetics · doi:10.1038/6002 · Cited by 379
Sibling correlations and segregation analysis of age‐related maculopathy: The beaver dam eye study
Heiba, I. M., Elston, R. C., Klein, B. E. K., & Klein, R. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110106 · Cited by 259
Marquet, S., Abel, L., Hillaire, D., Dessein, H., Kalil, J., Feingold, J., Weissenbach, J., & Dessein, A. J. (1996) · Nature Genetics · doi:10.1038/ng1096-181 · Cited by 251
Marquet, S., Abel, L., Hillaire, D., & Dessein, A. (1999) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200243 · Cited by 65
Metadata
- Authors
- Bonney, G. E., Opitz, J. M., & Reynolds, J. F.
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 1984-08
- Volume
- 18
- Issue
- 4
- Pages
- 731-749
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W1971619184
- Cited by
- 247
- References
- 0
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bonney, G. E., Opitz, J. M., & Reynolds, J. F. (1984). On the statistical determination of major gene mechanisms in continuous human traits: Regressive models. American Journal of Medical Genetics. https://doi.org/10.1002/ajmg.1320180420
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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