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Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33

Marquet, Sandrine, Abel, Laurent, Hillaire, Dominique, Dessein, Hélia, Kalil, Jorge, Feingold, Josué, Weissenbach, Jean, Dessein, Alain J.·1996·Nature Genetics
DOI 10.1038/ng1096-181
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Abstract

Three hundred million individuals are at risk of infection by schistosomes and around 200,000 die each year of this disease. Severe clinical disease in schistosomiasis is often the consequence of heavy infection which, in several endemic areas, are determined largely by the susceptibility/resistance of individuals. Previously, we reported evidence, based on a segregation analysis in Brazilian pedigrees, that intensity of infection by Schistosoma mansoni was influenced by a major gene, indicating that host genetic factors are probably critical in controlling schistosome infection and disease development. To localize this gene, referred to as SM1, we performed a genome-wide study on 142 Brazilian subjects belonging to 11 informative families Our results show a linkage to only one region, on chromosome 5q31-q33, with maximum two-point lod scores of +4.74 and +4.52 for D5S636 and the colony stimulating factor-1 receptor marker (CSF1R), respectively. This was corroborated by multipoint analysis, indicating a close proximity to CSF1R as the most likely location of SM1. This region contains several candidate genes encoding immunological molecules that were shown to play important roles in human protection against schistosomes.

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Metadata

Authors
Marquet, S., Abel, L., Hillaire, D., Dessein, H., Kalil, J., Feingold, J., Weissenbach, J., & Dessein, A. J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
1996-10
Volume
14
Issue
2
Pages
181-184
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng1096-181
Cited by
251
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33. https://app.cochat.ai/papers/10.1038/ng1096-181
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Marquet, S., Abel, L., Hillaire, D., Dessein, H., Kalil, J., Feingold, J., Weissenbach, J., & Dessein, A. J. (1996). Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33. Nature Genetics. https://doi.org/10.1038/ng1096-181