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Cited by 9Schizophrenia research and treatmentGenetic Associations and EpidemiologyPsychopathy, Forensic Psychiatry, Sexual Offending

Associations between risk factors for schizophrenia and concordance in four monozygotic twin samples

Pepper, Edward J., Pathmanathan, Sasi, McIlrae, Shona, Rehman, Faiz‐ur, Cardno, Alastair G.·2018·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
DOI 10.1002/ajmg.b.32640
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Abstract

Concordance for schizophrenia is high in monozygotic twins but the extent to which concordance varies according to the presence of other schizophrenia risk factors is not well established. We aimed to investigate this in systematically ascertained twin samples. DSM‐III‐R/DSM‐IV diagnoses were made from original data or published case histories from four systematically ascertained monozygotic twin samples. Probandwise concordance for schizophrenia was calculated according to the presence of psychotic disorder in first‐degree relatives, birth order, gender, and age‐at‐onset. Logistic regression analysis was also performed to adjust for potential confounders. Psychotic disorder in parents and earlier age‐at‐onset were significantly associated with higher probandwise concordance for schizophrenia, including after adjustment for potential confounders. For example, when no parents had a psychotic disorder concordance was 34/88 (38.6%) versus 10/16 (62.5%) when one parent was affected; and for age‐at‐onset <23 years concordance was 25/46 (54.3%), declining to 13/44 (29.5%) for age‐at‐onset >30 years. These results are consistent with psychotic disorder in parents and age‐at‐onset being markers of the level of familial liability to schizophrenia and these factors may be useful in genetic counseling of monozygotic twins and in identifying and managing those at particularly high risk, if these findings are further replicated.

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Authors
Pepper, E. J., Pathmanathan, S., McIlrae, S., Rehman, F., & Cardno, A. G.
Affiliations
  • University of Leeds (GB)
  • Lancashire Care NHS Foundation Trust (GB)
Corresponding author
Cardno, Alastair G.
ORCID
Cardno, Alastair G.
Venue
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher
Wiley
Published
2018-07
Volume
177
Issue
5
Pages
503-510
ISSN
  • 1552-4841 (ISSN-L)
  • 1552-485X
DOI
10.1002/ajmg.b.32640
OpenAlex
W2883273292
Cited by
9
References
45
Citations by year
2022: 2 · 2021: 2 · 2020: 4 · 2018: 1
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 22 d)
Locations
  • American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
schizophrenia, monozygotic twins, concordance, familial liability, age of onset, birth order, genetic counseling, risk factors
MeSH terms
Adult, Birth Order, Diseases in Twins, Family, Female, Humans, Male, Parents, Psychiatric Status Rating Scales, Psychotic Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology, Twins, Dizygotic, Twins, Monozygotic, Age of Onset, Young Adult

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