STING Deletion Protects Against Amyloid β‐induced Alzheimer's Disease Pathogenesis
Open accessAbstract
INTRODUCTION: While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis using genetic targeting approaches. METHODS: To investigate a role for the key innate immune adaptor molecule, stimulator of interferon genes (STING), in AD, we deleted Sting1 in the 5xFAD mouse model of AD‐related amyloidosis and evaluated the effects on pathology, neuroinflammation, gene expression, and cognition. RESULTS: Genetic ablation of STING in 5xFAD mice led to improved control of amyloid beta (Aβ) plaques, alterations in microglial activation status, decreased levels of neuritic dystrophy, and protection against cognitive decline. Moreover, rescue of neurological disease in STING‐deficient 5xFAD mice was characterized by reduced expression of type I interferon signaling genes in both microglia and excitatory neurons. DISCUSSION: These findings reveal critical roles for STING in Aβ‐driven neurological disease and suggest that STING‐targeting therapeutics may offer promising strategies to treat AD. Highlights: Stimulator of interferon genes (STING) deficiency in the 5xFAD mouse model of Alzheimer's disease‐related amyloidosis results in decreased amyloid beta (Aβ) deposition and altered microglial activation status. Protection against amyloidosis in STING‐deficient 5xFAD mice is associated with decreased expression of genes involved in type I IFN signaling, improved neuronal health, and reduced levels of oxidative stress. Loss of STING in 5xFAD mice leads to improved spatial learning and memory.
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STING interacts with cGAS and plays a significant role in Alzheimer's disease by promoting microglial dysfunction and neuroinflammation.
“The STING interacts with cGAS and plays a significant role in Alzheimer's disease by promoting microglial dysfunction and neuroinflammation [66, 67].”
From Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease (2026) · cites this paper as [67]
The Background describes cGAS as an upstream activator of STING, and the Results report that STING deletion dampened microglial activation and innate immune signaling in 5xFAD mice. But the Discussion says the cell types through which cGAS and STING promote AD-related progression remain undetermined, so the claim that STING acts *by* promoting microglial dysfunction states a mechanism more firmly than this paper establishes. (LLM, conf=0.85)
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Cites
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
Wolock, S. L., Lopez, R., & Klein, A. M. (2018) · doi:10.1101/357368 · Cited by 2,758 · see citing works
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
Ulland, T. K., Song, W. M., Huang, S. C.-C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.023 · Cited by 1,263 · see citing works
cGAS–STING drives ageing-related inflammation and neurodegeneration
Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., et al. (2023) · Nature · doi:10.1038/s41586-023-06373-1 · Cited by 1,074 · cited 1× · see citing works
“19 Here, it has largely been shown that knocking down cGAS and/or STING leads to an attenuation of neuroinflammatory responses and protection against neuronal cellloss.”
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151948 · Cited by 840 · see citing works
A Python library for probabilistic analysis of single-cell omics data
Gayoso, A., Lopez, R., Xing, G., Boyeau, P., Valiollah Pour Amiri, V., Hong, J., Wu, K., Jayasuriya, M., Mehlman, E., Langevin, M., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01206-w · Cited by 789 · see citing works
Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Remolina Serrano, J., Robinson, G. O., Anderson, E., Colonna, M., & Holtzman, D. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710311114 · Cited by 517 · see citing works
Li, W., Lu, L., Lu, J., Wang, X., Yang, C., Jin, J., Wu, L., Hong, X., Li, F., Cao, D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay9013 · Cited by 305 · see citing works
Emerging roles of innate and adaptive immunity in Alzheimer’s disease
Chen, X., & Holtzman, D. M. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.016 · Cited by 297 · see citing works
Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
Xie, X., Ma, G., Li, X., Zhao, J., Zhao, Z., & Zeng, J. (2023) · Nature Aging · doi:10.1038/s43587-022-00337-2 · Cited by 292 · see citing works
Tau Activation of Microglial cGAS–IFN Reduces MEF2C‐mediated Cognitive Resilience
Udeochu, J. C., Amin, S., Huang, Y., Fan, L., Torres, E. R. S., Carling, G. K., Liu, B., McGurran, H., Coronas-Samano, G., Kauwe, G., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01315-6 · Cited by 289 · see citing works
Deczkowska, A., Matcovitch-Natan, O., Tsitsou-Kampeli, A., Ben-Hamo, S., Dvir-Szternfeld, R., Spinrad, A., Singer, O., David, E., Winter, D. R., Smith, L. K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00769-0 · Cited by 260 · see citing works
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease
Cheng-Hathaway, P. J., Reed-Geaghan, E. G., Jay, T. R., Casali, B. T., Bemiller, S. M., Puntambekar, S. S., von Saucken, V. E., Williams, R. Y., Karlo, J. C., Moutinho, M., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0262-8 · Cited by 252 · see citing works
Sayed, F. A., Telpoukhovskaia, M., Kodama, L., Li, Y., Zhou, Y., Le, D., Hauduc, A., Ludwig, C., Gao, F., Clelland, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811411115 · Cited by 229 · cited 1× · see citing works
“57 The divergent roles that many discrete and hippocampal synaptic loss.”
Jorfi, M., Park, J., Hall, C. K., Lin, C.-C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01415-3 · Cited by 214 · see citing works
Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics
Podleśny-Drabiniok, A., Marcora, E., & Goate, A. M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.002 · Cited by 211 · see citing works
Caglayan, E., Liu, Y., & Konopka, G. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.010 · Cited by 123 · see citing works
Chung, S., Jeong, J.-H., Park, J.-C., Han, J. W., Lee, Y., Kim, J.-I., & Mook-Jung, I. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01295-y · Cited by 103 · see citing works
Flagged first, then by citations
Research works printed but not linked: 57
- [1]Heneka MT, van der Flier WM, Jessen F, et al. Neuroinflammation in Alzheimer disease. Nat Rev Immunol. 2025; 25: 321‐ 352. 39653749 PMC13148177
- [3]Ennerfelt HE, Lukens JR. The role of innate immunity in Alzheimer's disease. Immunol Rev. 2020; 297: 225‐ 246. 32588460 PMC7783860
- [4]Johnson AM, Lukens JR. The innate immune response in tauopathies. Eur J Immunol. 2023; 53: e2250266. 36932726 PMC10247424
- [5]Samuels JD, Lukens JR, Price RJ. Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer's disease‐related amyloidosis. J Neurochem. 2024; 168: 3558‐ 3573. 37822118 PMC11955997
- [6]Efthymiou AG, Goate AM. Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk. Mol Neurodegener. 2017; 12: 43. 28549481 PMC5446752
- [8]Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry. 2015; 77: 43‐ 51. 24951455 PMC4234692
- [9]Decout A, Katz JD, Venkatraman S, Ablasser A. The cGAS‐STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 2021; 21: 548‐ 569. 33833439 PMC8029610
- [10]Yang K, Tang Z, Xing C, Yan N. STING signaling in the brain: molecular threats, signaling activities, and therapeutic challenges. Neuron. 2024; 112: 539‐ 557. 37944521 PMC10922189
- [11]Ablasser A, Chen ZJ. cGAS in action: expanding roles in immunity and inflammation. Science. 2019; 363:eaat8657. 30846571
- [12]Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008; 455: 674‐ 678. 18724357 PMC2804933
- [13]Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'‐5'‐linked cyclic dinucleotide second messenger that activates STING. Nature. 2013; 498: 380‐ 384. 23722158 PMC4143541
- [14]Civril F, Deimling T, de Oliveira Mann CC, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature. 2013; 498: 332‐ 337. 23722159 PMC3768140
- [15]Burdette DL, Monroe KM, Sotelo‐Troha K, et al. STING is a direct innate immune sensor of cyclic di‐GMP. Nature. 2011; 478: 515‐ 518. 21947006 PMC3203314
- [16]Yu CH, Davidson S, Harapas CR, et al. TDP‐43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS. Cell. 2020; 183: 636‐ 649. 33031745 PMC7599077
- [18]Hinkle JT, Patel J, Panicker N, et al. STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha‐synucleinopathy. Proc Natl Acad Sci U S A. 2022; 119: e2118819119. 35394877 PMC9169780
- [20]Huang Y, Liu B, Sinha SC, Amin S, Gan L. Mechanism and therapeutic potential of targeting cGAS‐STING signaling in neurological disorders. Mol Neurodegener. 2023; 18: 79. 37941028 PMC10634099
- [23]Barasa L, Chaudhuri S, Zhou JY, et al. Development of LB244, an irreversible STING antagonist. J Am Chem Soc. 2023; 145: 20273‐ 20288. 37695732 PMC11059204
- [24]Hong Z, Mei J, Li C, et al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021; 118: e2105465118. 34099558 PMC8214703
- [26]Jin L, Hill KK, Filak H. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic‐di‐AMP and cyclic‐di‐GMP. J Immunol. 2011; 187: 2595‐ 2601. 21813776 PMC3159690
- [27]Da Mesquita S, Louveau A, Vaccari A, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. 2018; 560: 185‐ 191. 30046111 PMC6085146
- [28]Wolf FA, Angerer P, Theis FJ. SCANPY: large‐scale single‐cell gene expression data analysis. Genome Biol. 2018; 19: 15. 29409532 PMC5802054
- [30]Bernstein NJ, Fong NL, Lam I, Roy MA, Hendrickson DG, Kelley DR. Solo: doublet identification in single‐cell RNA‐Seq via semi‐supervised deep learning. Cell Syst. 2020; 11: 95‐ 101. 32592658
- [32]Eraslan G, Drokhlyansky E, Anand S, et al. Single‐nucleus cross‐tissue molecular reference maps toward understanding disease gene function. Science. 2022; 376: eabl4290. 35549429 PMC9383269
- [34]Ferecsko AS, Smallwood MJ, Moore A, et al. STING‐triggered CNS inflammation in human neurodegenerative diseases. Biomedicines. 2023; 11. PMC10216406 37239045
- [35]Suberbielle E, Sanchez PE, Kravitz AV, et al. Physiologic brain activity causes DNA double‐strand breaks in neurons, with exacerbation by amyloid‐beta. Nat Neurosci. 2013; 16: 613‐ 621. 23525040 PMC3637871
- [36]Shanbhag NM, Evans MD, Mao W, et al. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019; 7: 77. 31101070 PMC6524256
- [37]Ren J, Zhang S, Wang X, et al. MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer's disease in vivo and in vitro. Acta Biochim Biophys Sin. 2022; 54: 77‐ 90. 35130621 PMC9909301
- [39]Woo RS, Lee JH, Yu HN, Song DY, Baik TK. Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP/PS1 mice, a model of Alzheimer's disease. Anat Cell Biol. 2011; 44: 116‐ 127. 21829755 PMC3145840
- [40]Lee HJ, Jung KM, Huang YZ, et al. Presenilin‐dependent gamma‐secretase‐like intramembrane cleavage of ErbB4. J Biol Chem. 2002; 277: 6318‐ 6323. 11741961
- [41]Zhang H, Zhang L, Zhou D, et al. Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer's disease. Neurobiol Dis. 2017; 106: 171‐ 180. 28684271
- [42]Zhang H, Zhang L, Zhou D, Li H, Xu Y. ErbB4 mediates amyloid beta‐induced neurotoxicity through JNK/tau pathway activation: implications for Alzheimer's disease. J Comp Neurol. 2021; 529: 3497‐ 3512. 34212389
- [43]Montine TJ, Neely MD, Quinn JF, et al. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med. 2002; 33: 620‐ 626. 12208348
- [44]Garcia‐Alloza M, Dodwell SA, Meyer‐Luehmann M, Hyman BT, Bacskai BJ. Plaque‐derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol. 2006; 65: 1082‐ 1089. 17086105
- [45]Ferre‐Gonzalez L, Pena‐Bautista C, Baquero M, Chafer‐Pericas C. Assessment of lipid peroxidation in Alzheimer's disease differential diagnosis and prognosis. Antioxidants (Basel). 2022; 11: 551. 35326200 PMC8944831
- [46]Lopez N, Tormo C, De Blas I, Llinares I, Alom J. Oxidative stress in Alzheimer's disease and mild cognitive impairment with high sensitivity and specificity. J Alzheimers Dis. 2013; 33: 823‐ 829. 23076075
- [47]Zhao Y, Wu X, Li X, et al. TREM2 is a receptor for beta‐amyloid that mediates microglial function. Neuron. 2018; 97: 1023‐ 1031. 29518356 PMC5889092
- [48]Jay TR, Hirsch AM, Broihier ML, et al. Disease progression‐dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease. J Neurosci. 2017; 37: 637‐ 647. 28100745 PMC5242410
- [51]Wang Y, Cella M, Mallinson K, et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 2015; 160: 1061‐ 1071. 25728668 PMC4477963
- [53]Yuan P, Condello C, Keene CD, et al. TREM2 Haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron. 2016; 92: 252‐ 264. 27710785
- [54]Song WM, Joshita S, Zhou Y, Ulland TK, Gilfillan S, Colonna M. Humanized TREM2 mice reveal microglia‐intrinsic and ‐extrinsic effects of R47H polymorphism. J Exp Med. 2018; 215: 745‐ 760. 29321225 PMC5839761
- [55]Leyns CEG, Gratuze M, Narasimhan S, et al. TREM2 function impedes tau seeding in neuritic plaques. Nat Neurosci. 2019; 22: 1217‐ 1222. 31235932 PMC6660358
- [58]Carling GK, Fan L, Foxe NR, et al. Alzheimer's disease‐linked risk alleles elevate microglial cGAS‐associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024; 112: 3877‐ 3896. 39353433 PMC11624100
- [59]Jeltema D, Abbott K, Yan N. STING trafficking as a new dimension of immune signaling. J Exp Med. 2023; 220: e20220990. 36705629 PMC9930166
- [60]Szabo MP, Mishra S, Knupp A, Young JE. The role of Alzheimer's disease risk genes in endolysosomal pathways. Neurobiol Dis. 2022; 162: 105576. 34871734 PMC9071255
- [61]Liu Y, Wang A, Chen C, et al. Microglial cGAS‐STING signaling underlies glaucoma pathogenesis. Proc Natl Acad Sci U S A. 2024; 121: e2409493121. 39190350 PMC11388346
- [62]Marques C, Held A, Dorfman K, et al. Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia. Acta Neuropathol. 2024; 147: 56. 38478117 PMC10937762
- [63]Woo MS, Mayer C, Binkle‐Ladisch L, et al. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024; 187: 4043‐ 4060. 38878778
- [64]Gate D, Saligrama N, Leventhal O, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020; 577: 399‐ 404. 31915375 PMC7445078
- [66]Machhi J, Yeapuri P, Lu Y, et al. CD4+ effector T cells accelerate Alzheimer's disease in mice. J Neuroinflammation. 2021; 18: 272. 34798897 PMC8603581
- [67]Chen X, Firulyova M, Manis M, et al. Microglia‐mediated T cell infiltration drives neurodegeneration in tauopathy. Nature. 2023; 615: 668‐ 677. 36890231 PMC10258627
- [68]Su W, Saravia J, Risch I, et al. CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse Alzheimer's disease pathology. Nat Immunol. 2023; 24: 1735‐ 1747. 37679549 PMC11102766
- [69]Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A. Cutting edge: activation of STING in T cells induces type I IFN responses and cell death. J Immunol. 2017; 199: 397‐ 402. 28615418 PMC5525333
- [71]Wu J, Chen YJ, Dobbs N, et al. STING‐mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med. 2019; 216: 867‐ 883. 30886058 PMC6446864
- [72]Pais TF, Ali H, Moreira da Silva J, et al. Brain endothelial STING1 activation by Plasmodium‐sequestered heme promotes cerebral malaria via type I IFN response. Proc Natl Acad Sci U S A. 2022; 119: e2206327119. 36037380 PMC9457060
- [73]Liu H, Ghosh S, Vaidya T, et al. Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy. JCI Insight. 2023; 8: e168945. 37345657 PMC10371250
- [74]Gao KM, Chiang K, Jiang Z, et al. Endothelial cell expression of a STING gain‐of‐function mutation initiates pulmonary lymphocytic infiltration. Cell Rep. 2024; 43: 114114. 38625791 PMC11108094
- [75]Wang A, Chen C, Mei C, et al. Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders. Nat Cell Biol. 2024; 26: 219‐ 234. 38253667
Cited by
Sorted by citations
Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease
Kim, B., Wang, S. S., Kim, J. R., & Kim, J. (2026) · BioEssays · doi:10.1002/bies.70186
- Authors
- Thanos, J. M., Campbell, O. C., Cowan, M. N., Bruch, K. R., Moore, K. A., Ennerfelt, H. E., Natale, N. R., Mangalmurti, A., Kerur, N., & Lukens, J. R.
- Affiliations
- University of Virginia (US)
- Massachusetts General Hospital (US)
- Stanford University (US)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Lukens, John R.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2025-05
- Volume
- 21
- Issue
- 5
- Pages
- e70305-e70305
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC12101966
- OpenAlex
- W4410638645
- Cited by
- 26
- References
- 18
- Citations by year
- 2026: 17 · 2025: 9
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01AG071996, R01AG087406, RF1AG078684)
- National Institute of Neurological Disorders and Stroke (T32NS115657)
- Owens Family Foundation (Grant)
- Cure Alzheimer's Fund (Grant)
- Alzheimer's Association (ADSF‐21‐816651)
- National Institute on Aging (RF1AG078684)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- STING, Alzheimer's disease
- MeSH terms
- STING Protein, Alzheimer Disease, Animals, Disease Models, Animal, Humans, Membrane Proteins, Mice, Transgenic, Amyloid beta-Peptides, Microglia, Mice, Plaque, Amyloid
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