cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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A human memory T cell subset with stem cell–like properties

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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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Mitotic progression following DNA damage enables pattern recognition within micronuclei

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A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

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STING: infection, inflammation and cancer.

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

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The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

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Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

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A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

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Mitochondrial DNA in innate immune responses and inflammatory pathology

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The Principles of Engineering Immune Cells to Treat Cancer

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cGAS in action: Expanding roles in immunity and inflammation

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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

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T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

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Mitochondria in the Regulation of Innate and Adaptive Immunity

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ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

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Design of amidobenzimidazole STING receptor agonists with systemic activity

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Targeting DNA damage response promotes antitumor immunity through STING-mediated T-cell activation in small cell lung cancer

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Therapeutic T cell engineering

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NR4A transcription factors limit CAR T cell function in solid tumours

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CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

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PARP inhibitor efficacy depends on CD8(+) T-cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer

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TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

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CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

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The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

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A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

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T memory stem cells in health and disease

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The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness

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T cell stemness and dysfunction in tumors are triggered by a common mechanism

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Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

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Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

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Signalling strength determines proapoptotic functions of STING

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

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Emerging Cellular Therapies for Cancer

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Prospects for gene-engineered T cell immunotherapy for solid cancers

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Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

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LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

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STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

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Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

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Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

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Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers

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Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity

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The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

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Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

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cGAS Conducts Micronuclei DNA Surveillance

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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

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STING-induced regulatory B cells compromise NK function in cancer immunity

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Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

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Harnessing innate immune pathways for therapeutic advancement in cancer

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Radiation-induced tumor immune microenvironments and potential targets for combination therapy

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Targeting innate immune pathways for cancer immunotherapy

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Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

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Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

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The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

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The cGAS/STING Pathway: A Novel Target for Cancer Therapy

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ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

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The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

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Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity

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Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

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The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

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Inflammation in cancer: therapeutic opportunities from new insights

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The Role of Oxidative Stress in Tumorigenesis and Progression

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The role of cGAS-STING signalling in liver diseases

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Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

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Blockade of STING Activation Alleviates Microglial Dysfunction and a Broad Spectrum of Alzheimer's Disease Pathologies

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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

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Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

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Epigenetic state determines the in vivo efficacy of STING agonist therapy

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Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways

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CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T _H 1 and T _H 9 cells

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cGAS-STING signaling in the tumor microenvironment

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Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

Chen, X., Xu, Z., Li, T., Thakur, A., Wen, Y., Zhang, K., Liu, Y., Liang, Q., Liu, W., Qin, J., et al. (2024) · Biomarker Research · doi:10.1186/s40364-023-00551-z · Cited by 83 · see citing works

Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals

Hao, M., Zhu, L., Hou, S., Chen, S., Li, X., Li, K., Zhu, N., Chen, S., Xue, L., Ju, C., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c11764 · Cited by 80 · see citing works

Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy

Su, T., Cheng, F., Qi, J., Zhang, Y. X., Zhou, S., Mei, L., Fu, S., Zhang, F., Lin, S., & Zhu, G. (2022) · Advanced Science · doi:10.1002/advs.202201895 · Cited by 79 · see citing works

DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response

Cinat, D., Coppes, R. P., & Barazzuol, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.729136 · Cited by 78 · see citing works

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

Shen, R., Liu, D., Wang, X., Guo, Z., Sun, H., Song, Y., & Wang, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.828657 · Cited by 76 · see citing works

cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy

Long, Z., Wang, J., Xu, J., Lei, X., & Liu, Q. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.044 · Cited by 73 · see citing works

STING agonism turns human T cells into interferon‐producing cells but impedes their functionality

Kühl, N., Linder, A., Philipp, N., Nixdorf, D., Fischer, H., Veth, S., Kuut, G., Xu, T. T., Theurich, S., Carell, T., et al. (2023) · EMBO Reports · doi:10.15252/embr.202255536 · Cited by 70 · see citing works

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Lu, L., Yang, C., Zhou, X., Wu, L., Hong, X., Li, W., Wang, X., Yang, Y., Cao, D., Zhang, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113108 · Cited by 74 · see citing works

Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis

Wang, R., Singaraju, A., Marks, K. E., Shakib, L., Dunlap, G. S., Adejoorin, I., Greisen, S. R., Chen, L., Tirpack, A., Aude, C. A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add1591 · Cited by 70 · see citing works

Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy

Zeng, Q., Liu, M., Wang, Z., Zhou, R., & Ai, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02366-y · Cited by 81 · see citing works

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang, Y., Zou, M., Wu, H., Zhu, J., & Jin, T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106710 · Cited by 70 · see citing works

Zinc‐Organometallic Framework Vaccine Controlled‐Release Zn ²⁺ Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy

Ding, L., Liang, M., Li, Y., Zeng, M., Liu, M., Ma, W., Chen, F., Li, C., Reis, R. L., Li, F., et al. (2023) · Advanced Science · doi:10.1002/advs.202302967 · Cited by 68 · see citing works

A STING pathway-activatable contrast agent for MRI-guided tumor immunoferroptosis synergistic therapy

Guo, S., Xiong, W., Zhu, J., Feng, J., Zhou, R., Fan, Q., Zhang, Q., Li, Z., Yang, H. J., Zhou, H., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122300 · Cited by 67 · see citing works

CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

Gao, J., Wu, Z., Zhao, M., Zhang, R., Li, M., Sun, D., Cheng, H., Qi, X., Shen, Y., Xu, Q., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.006 · Cited by 64 · see citing works

Targeting STING for cancer immunotherapy: From mechanisms to translation

Huang, R., Ning, Q., Zhao, J., Zhao, X., Zeng, L., Yi, Y., & Tang, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109304 · Cited by 61 · see citing works

Opportunities and challenges of targeting cGAS–STING in cancer

Lu, C., Wang, W., & Fu, Y. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-025-00894-9 · Cited by 70 · see citing works

When DNA-damage responses meet innate and adaptive immunity

Tong, J., Song, J., Zhang, W., Zhai, J., Guan, Q., Wang, H., Liu, G., & Zheng, C. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05214-2 · Cited by 63 · see citing works

Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants

Conde, E., Vercher, E., Soria-Castellano, M., Suárez-Olmos, J., Mancheño, U., Elizalde, E., Rodriguez, M. L., Glez‐Vaz, J., Casares, N., Rodríguez‐García, E., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003351 · Cited by 59 · see citing works

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 59 · see citing works

The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

Uslu, U., Sun, L., Castelli, S., Finck, A., Assenmacher, C., Young, R. M., Chen, Z. J., & June, C. H. (2024) · Nature Communications · doi:10.1038/s41467-024-47692-9 · Cited by 61 · see citing works

Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism

Huang, Y., Shao, M., Teng, X., Si, X., Wu, L., Jiang, P., Liu, L., Cai, B., Wang, X., Han, Y., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101400 · Cited by 58 · see citing works

STING agonist-based hydrogel enhances immune activation in synergy with radiofrequency ablation for hepatocellular carcinoma treatment

Ao, F., Li, X., Tan, Y. Z., Jiang, Z., Yang, F., Guo, J., Zhu, Q., Chen, Z., Zhou, B., Zhang, K., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.048 · Cited by 57 · see citing works

Mitochondria during T cell aging

Escrig-Larena, J. I., Delgado-Pulido, S., & Mittelbrunn, M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101808 · Cited by 58 · see citing works

Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities

Wang, H., Niu, X., Jin, Z., Zhang, S., Fan, R., Xiao, H., & Hu, S. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03519-z · Cited by 59 · see citing works

Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy

Dou, Y., Chen, R., Liu, S., Lee, Y., Ji, J., Liu, X., Ke, Y., Wang, R., Zhou, Y., & Huang, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-41164-2 · Cited by 54 · see citing works

Targeting STING in cancer: Challenges and emerging opportunities

Zhao, K., Huang, J., Zhao, Y., Wang, S., Xu, J., & Yin, K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188983 · Cited by 55 · see citing works

The interplay between autophagy and cGAS-STING signaling and its implications for cancer

Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 55 · see citing works

Lactobacillus rhamnosus GG alleviates radiation-induced intestinal injury by modulating intestinal immunity and remodeling gut microbiota

Zhang, L., Xu, J.-Y., Xing, Y., Wu, P., Jin, Y.-W., Wei, W., Zhao, L., Yang, J., Chen, G., & Qin, L. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127821 · Cited by 50 · see citing works

Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?

Berthelot, J., Lioté, F., Maugars, Y., & Sibilia, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607069 · Cited by 52 · see citing works

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

Shi, J., Liu, C., Luo, S., Cao, T., Lin, B., Zhou, M., Zhang, X., Wang, S., Zheng, T., & Li, X. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104384 · Cited by 51 · see citing works

Tumor-targeting nanocarriers amplified immunotherapy of cold tumors by STING activation and inhibiting immune evasion

Zhao, J., Tong, A., Liu, J., Xu, M., & Mi, P. (2025) · Science Advances · doi:10.1126/sciadv.adr1728 · Cited by 51 · see citing works

Unlocking the promise of systemic STING agonist for cancer immunotherapy

Sun, X., Zhou, X., Lei, Y. L., & Moon, J. J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.047 · Cited by 47 · see citing works

Cancer immunotherapy strategies that target the cGAS-STING pathway

Tian, Z., Zeng, Y., Peng, Y., Liu, J., & Wu, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.996663 · Cited by 47 · see citing works

Ionizable STING-Activating Nanoadjuvants Enhance Tumor Immunogenicity and Potentiate Immunotherapy Efficacy in Solid Tumors

Xian, S., Chen, X., Ren, S., Chen, X., & Wang, H. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3511 · Cited by 41 · see citing works

STING-Activating Polymer–Drug Conjugates for Cancer Immunotherapy

Sheehy, T. L., Kwiatkowski, A. J., Arora, K., Kimmel, B. R., Schulman, J. A., Gibson-Corley, K. N., & Wilson, J. T. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00579 · Cited by 41 · see citing works

Metabolic dynamics instruct CD8 + T‐cell differentiation and functions

Bevilacqua, A., Li, Z., & Ho, P. (2022) · European Journal of Immunology · doi:10.1002/eji.202149486 · Cited by 38 · see citing works

A next-generation STING agonist MSA-2: From mechanism to application

Yang, J., Luo, Z., Ma, J., Wang, Y., & Cheng, N. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.042 · Cited by 40 · see citing works

How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?

Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1840567 · Cited by 39 · see citing works

Inhibiting mtDNA‐STING‐NLRP3 / IL ‐1β axis‐mediated neutrophil infiltration protects neurons in Alzheimer's disease

Xia, X., He, X., Zhao, T., Yang, J., Bi, Z., Fu, Q., Liu, J., Ao, D., Wei, Y., & Wei, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13529 · Cited by 38 · see citing works

Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

Li, Y., Han, M., Wei, H., Huang, W., Chen, Z., Zhang, T., Qian, M., Lin, J., Nan, G., Sun, X., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01118-6 · Cited by 38 · see citing works

Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy

Ma, X., He, C., Wang, Y., Cao, X., Jin, Z., Ge, Y., Cao, Z., An, M., & Hao, L. (2025) · Biomaterials Research · doi:10.34133/bmr.0158 · Cited by 37 · see citing works

cGAS and cancer therapy: a double-edged sword

Du, J., Qian, M., Yuan, T., Chen, R., He, Q., Yang, B., Ling, Q., & Zhu, H. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00839-6 · Cited by 39 · see citing works

Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti‐Tumor Immunity

Ma, H., Fang, W., Li, Q., Wang, Y., & Hou, X. S. (2023) · Advanced Science · doi:10.1002/advs.202305089 · Cited by 36 · see citing works

CAR-T therapy and targeted treatments: Emerging combination strategies in solid tumors

Liu, J., Jiao, X., Ma, D., Fang, Y., & Gao, Q. (2024) · Med · doi:10.1016/j.medj.2024.03.001 · Cited by 35 · see citing works

The multifaceted functions of cGAS

Liu, H., Wang, F., Cao, Y., Dang, Y., & Ge, B. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac031 · Cited by 34 · see citing works

Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

Zhao, X., Hu, S., Zeng, L., Liu, X., Song, Y., Zhang, Y., Chen, Q., Bai, Y., Zhang, J., Zhang, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104690 · Cited by 34 · see citing works

Enhancing immunotherapy outcomes by targeted remodeling of the tumor microenvironment via combined cGAS-STING pathway strategies

Huang, M., Cha, Z., Liu, R., Lin, M., Gafoor, N. A., Kong, T., Ge, F., & Chen, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399926 · Cited by 34 · see citing works

DNA‐Capturing Manganese‐Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS‐STING Pathway and Maintaining Tumor‐Infiltrating CD8 + T‐Cell Stemness

Zhang, S., Wang, C., Zhu, Y., Gao, J., Yan, Y., Chen, M., Yan, X., Liu, Z., & Feng, L. (2025) · Advanced Materials · doi:10.1002/adma.202418583 · Cited by 35 · see citing works

Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs

Shang, Y., Hu, X., Ren, M., Ma, L., Zhao, X., Gao, C., Zhang, L., Li, S., Liu, L., Zou, B., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02375-9 · Cited by 33 · see citing works

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Yan, Y., Tan, X., Song, B., Yi, M., Chu, Q., & Wu, K. (2025) · 癌症：英文版 · doi:10.1002/cac2.70067 · Cited by 35 · see citing works

Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy

Wang, Y., Liu, Y., Zhang, J., Peng, Q., Wang, X., Xiao, X., & Shi, K. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.008 · Cited by 31 · see citing works

The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy

Ribeiro, A. R. S., Neuper, T., & Horejs‐Hoeck, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s477320 · Cited by 32 · see citing works

The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment

Li, J., & Bakhoum, S. F. W. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac019 · Cited by 29 · see citing works

cGAS‐STING signaling in cancer: Regulation and therapeutic targeting

Fan, X., Song, X., Chen, W., Liang, H., Nakatsukasa, H., & Zhang, D. (2023) · MedComm – Oncology · doi:10.1002/mog2.49 · Cited by 29 · see citing works

A Polymeric mRNA Vaccine Featuring Enhanced Site‐Specific mRNA Delivery and Inherent STING‐Stimulating Performance for Tumor Immunotherapy

Guo, X., Yang, Z., Guo, Z., Lai, H., Meng, H., Meng, M., Li, T., Li, Z., Chen, J., Feng, Y., et al. (2025) · Advanced Materials · doi:10.1002/adma.202410998 · Cited by 29 · see citing works

Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway

Yang, Y. A., Qi, J., Hu, J., Zhou, Y., Zheng, J., Deng, W., Inam, M., Guo, J., Xie, Y., Li, Y., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216765 · Cited by 28 · see citing works

ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells

Wang, F., Zhang, Y., Yu, X., Teng, X.-L., Ding, R., Hu, Z., Wang, A., Wang, Z., Ye, Y., & Zou, Q. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144318 · Cited by 28 · see citing works

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

Serrano, R., Lettau, M., Zarobkiewicz, M. K., Wesch, D., Peters, C., & Kabelitz, D. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2030021 · Cited by 28 · see citing works

Advanced nanomaterials targeting activation of STING for enhanced cancer immunotherapy

Tan, J., Wang, M., Ding, B., Ma, P., & Lin, J. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215316 · Cited by 27 · see citing works

Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus

Floyd, W., Pierpoint, M., Su, C., Patel, R., Luo, L., Deland, K., Wisdom, A. J., Zhu, D., Ma, Y., DeWitt, S. B., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci149310 · Cited by 27 · see citing works

γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

Luo, J., Wang, S., Yang, Q., Fu, Q., Zhu, C., Li, T., Yang, S., Zhao, Y., Guo, R., Ben, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202404432 · Cited by 26 · see citing works

STING Deletion Protects Against Amyloid β‐induced Alzheimer's Disease Pathogenesis

Thanos, J. M., Campbell, O. C., Cowan, M. N., Bruch, K. R., Moore, K. A., Ennerfelt, H. E., Natale, N. R., Mangalmurti, A., Kerur, N., & Lukens, J. R. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70305 · Cited by 26 · see citing works

STING in cancer immunoediting: Modeling tumor-immune dynamics throughout cancer development

Zhang, X., Chen, Y., Liu, X., Li, G., Zhang, S., Zhang, Q., Cui, Z., Qin, M., Simon, H., Terzić, J., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2024.217410 · Cited by 27 · see citing works

Cholesterol biosynthesis induced by radiotherapy inhibits cGAS–STING activation and contributes to colorectal cancer treatment resistance

Zhu, L., Tang, Z., Jiang, W., Dong, Y., Li, X., Huang, K., Wu, T., Xu, L., Guo, W., & Gu, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01457-6 · Cited by 25 · see citing works

The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

Zhou, Z., Huang, S., Fan, F., Xu, Y., Moore, C., Li, S., & Han, C. (2024) · Medical Review · doi:10.1515/mr-2023-0061 · Cited by 25 · see citing works

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy

Zhang, Y., Wang, Y., Mu, P., Zhu, X. G., & Dong, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1470468 · Cited by 24 · see citing works

The STING pathway: Therapeutic vulnerabilities in ovarian cancer

Shakfa, N. E., Li, D., Nersesian, S., Wilson‐Sanchez, J., & Koti, M. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01797-4 · Cited by 24 · see citing works

A cytotoxic T cell inspired oncolytic nanosystem promotes lytic cell death by lipid peroxidation and elicits antitumor immune responses

Zuo, Z., Yin, H., Zhang, Y., Xie, C., & Wang, Q. (2023) · Nature Communications · doi:10.1038/s41467-023-41335-1 · Cited by 24 · see citing works

Dynamic STING repression orchestrates immune cell development and function

Knox, K., Jeltema, D., Dobbs, N., Yang, K., Xing, C., Song, K., Tang, Z., Torres-Ramirez, G., Wang, J., Gao, S., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado9933 · Cited by 23 · see citing works

Fumarate integrates metabolism and immunity in diseases

Cheng, J., Xiao, Y., & Jiang, P. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.03.008 · Cited by 23 · see citing works

cGAS-STING signaling in cancer immunity and immunotherapy

Du, H., Xu, T., & Cui, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110972 · Cited by 105 · see citing works

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

Wang, Y., Angulo-Lozano, J. C., Wang, Y., & Deng, L. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204552 · Cited by 2 · see citing works

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

Alabi, F. A., Imodoye, S. O., Adedokun, K. A., Eltokhy, M. A., Curcic, M., Okoyeocha, E., Thapa, I., Tiwari, S., Ogundele, A. V., Ayo, T. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760947 · Cited by 4 · see citing works

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

Liu, F.-R., Jiang, M., Mei, Z., Lin, C.-J., & Tian, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101404 · Cited by 24 · see citing works

Intuitive CD8+ T cells sense DNA

Pujanandez, L. (2020) · Science · doi:10.1126/science.368.6498.1443-t