The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Potassium channel antibodies in two patients with reversible limbic encephalitis
Abstract
Limbic encephalitis (LE) is often associated with lung, thymic, or testicular tumours and antibodies to Hu, CV2, or Ma2 (Ta) antigens. In these cases, it generally has a poor prognosis. Here we describe two patients with symptoms of LE, negative for typical paraneoplastic antibodies, in whom antibodies to voltage‐gated potassium channels (VGKC) were detected retrospectively in serial serum samples. Patient 1 had a thymoma recurrence, but in patient 2 no tumour has been detected in the years following presentation. Plasma exchange was effective in reducing VGKC antibody levels, with substantial improvement in mental symptoms in patient 1. In patient 2, the VGKC antibodies fell spontaneously over two years, with almost complete recovery of mental function. Although neither patient had obvious neuromyotonia at presentation, both showed excessive secretions. We suggest that patients with limbic symptoms and excessive secretions should be tested for VGKC antibodies, and, if they are present, prompt and effective immunosuppressive treatment should be considered.
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Lai, M., Huijbers, M. G., Lancaster, E., Graus, F., Bataller, L., Balice-Gordon, R., Cowell, J. K., & Dalmau, J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70137-x · Cited by 1,361
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Self-citationFatigue in neurological disorders
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Metadata
- Authors
- Buckley, C., Oger, J., Clover, L., Tüzün, E., Carpenter, K., Jackson, M., & Vincent, A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-06-26
- Volume
- 50
- Issue
- 1
- Pages
- 73-78
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1996510251
- Cited by
- 444
- References
- 17
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Buckley, C., Oger, J., Clover, L., Tüzün, E., Carpenter, K., Jackson, M., & Vincent, A. (2001). Potassium channel antibodies in two patients with reversible limbic encephalitis. Annals of Neurology. https://doi.org/10.1002/ana.1097
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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